Substrates for peptidase S01.142: duodenase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Angiotensin-1	P01019	34-43	Peptide-Phe41+His-Leu	N	NT	Ile	His	Pro	Phe	His	Leu	-	-	Pemberton et al., 1997
Angiotensin-1	P01019	34-43	Asp-Arg-Val-Tyr37+Ile-Peptide	N	NT	Asp	Arg	Val	Tyr	Ile	His	Pro	Phe	Pemberton et al., 1997
arginyl bond			peptide-Arg+peptide	N		-	-	NPe	Arg	CPe	-	-	-
Bradykinin	P01042	381-389	Peptide-Phe388+Arg	N	NT	Phe	Ser	Pro	Phe	Arg	-	-	-	Pemberton et al., 1997
Fibrinogen beta chain	P02676	22-468	Peptide-Lys28+Lys-Peptide	N	MS	Pro	Tyr	Asp	Lys	Lys	Lys	Glu	Glu	Pemberton et al., 1997
Insulin B chain (oxidized)	P01308	25-54	Peptide-Leu39+Tyr-Peptide	N	NT	Val	Glu	Ala	Leu	Tyr	Leu	Val	Cys	Pemberton et al., 1997
leucyl bond			peptide-Leu+peptide	N		-	-	NPe	Leu	CPe	-	-	-
lysyl bond			peptide-Lys+peptide	N		-	-	NPe	Lys	CPe	-	-	-
phenylalanyl bond			peptide-Phe+peptide	N		-	-	NPe	Phe	CPe	-	-	-
Serum albumin	P02769	25-607	Peptide-Lys138+Leu-Peptide	N	NT	Asp	Leu	Pro	Lys	Leu	Lys	Pro	Asp	Pemberton et al., 1997
Serum albumin	P02769	25-607	Peptide-Lys263+Val-Peptide	N	NT	Asp	Leu	Thr	Lys	Val	His	Lys	Glu	Pemberton et al., 1997
Serum albumin	P02769	25-607	Peptide-Lys285+Tyr-Peptide	N	NT	Asp	Leu	Ala	Lys	Tyr	Ile	Cys	Asp	Pemberton et al., 1997
Serum albumin	P02769	25-607	Peptide-Lys401+His-Peptide	N	NT	Asp	Lys	Leu	Lys	His	Leu	Val	Asp	Pemberton et al., 1997
Substance P	P20366	58-68	Peptide-Phe64+Phe-Gly-Leu-Met	N	NT	Pro	Gln	Gln	Phe	Phe	Gly	Leu	Met	Pemberton et al., 1997
Substance P	P20366	58-68	Peptide-Leu67+Met	N	NT	Phe	Phe	Gly	Leu	Met	-	-	-	Pemberton et al., 1997
Suc-Phe-Leu-Phe-SBzl			Suc-Phe-Leu-Phe+SBzl	S		Suc	Phe	Leu	Phe	SBz	-	-	-
Tos-Gly-Pro-Lys-NHPhNO2			Tos-Gly-Pro-Lys+NHPhNO2	S		Tos	Gly	Pro	Lys	NAN	-	-	-
tyrosyl bond			peptide-Tyr+peptide	N		-	-	NPe	Tyr	CPe	-	-	-
Z-Lys-SBzl			Z-Lys+SBzl	S		-	-	Z	Lys	SBz	-	-	-