6zsc

Electron Microscopy
3.5Å resolution

Human mitochondrial ribosome in complex with E-site tRNA

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis of mitochondrial translation.
OpenAccess logo Elife 9 (2020)
PMID: 32812867
Related structures: EMD-11393

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 91-mer (preferred)
PDBe Complex ID:
PDB-CPX-240765 (preferred)
Entry contents:
82 distinct polypeptide molecules
4 distinct RNA molecules
Macromolecules (86 distinct):
Large ribosomal subunit protein bL32m Chain: 0
Molecule details ›
Chain: 0
Length: 188 amino acids
Theoretical weight: 21.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC8 (Residues: 1-188; Coverage: 100%)
Gene names: HSPC283, MRPL32
Sequence domains: Ribosomal L32p protein family
Large ribosomal subunit protein bL33m Chain: 1
Molecule details ›
Chain: 1
Length: 65 amino acids
Theoretical weight: 7.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75394 (Residues: 1-65; Coverage: 100%)
Gene names: C2orf1, MRPL33
Sequence domains: Ribosomal protein L33
Large ribosomal subunit protein bL34m Chain: 2
Large ribosomal subunit protein bL35m Chain: 3
Large ribosomal subunit protein bL36m Chain: 4
Large ribosomal subunit protein mL37 Chain: 5
Large ribosomal subunit protein mL38 Chain: 6
Large ribosomal subunit protein mL39 Chain: 7
Large ribosomal subunit protein mL40 Chain: 8
Large ribosomal subunit protein mL41 Chain: 9
Small ribosomal subunit protein mS34 Chain: A0
Small ribosomal subunit protein mS35 Chain: A1
Small ribosomal subunit protein mS37 Chain: A2
Small ribosomal subunit protein mS38 Chain: A3
Small ribosomal subunit protein mS39 Chain: A4
Small ribosomal subunit protein uS2m Chain: AB
Small ribosomal subunit protein uS3m Chain: AC
Small ribosomal subunit protein uS5m Chain: AD
Small ribosomal subunit protein bS6m Chain: AE
Small ribosomal subunit protein uS7m Chain: AF
Small ribosomal subunit protein uS9m Chain: AG
Small ribosomal subunit protein uS10m Chain: AH
Small ribosomal subunit protein uS11m Chain: AI
Small ribosomal subunit protein uS12m Chain: AJ
Small ribosomal subunit protein uS14m Chain: AK
Small ribosomal subunit protein uS15m Chain: AL
Small ribosomal subunit protein bS16m Chain: AM
Small ribosomal subunit protein uS17m Chain: AN
Small ribosomal subunit protein mS40 Chain: AO
Small ribosomal subunit protein bS18m Chain: AP
Small ribosomal subunit protein bS21m Chain: AQ
Small ribosomal subunit protein mS22 Chain: AR
Small ribosomal subunit protein mS23 Chain: AS
Small ribosomal subunit protein mS25 Chain: AT
Small ribosomal subunit protein mS26 Chain: AU
Small ribosomal subunit protein mS27 Chain: AV
Small ribosomal subunit protein bS1m Chain: AW
Small ribosomal subunit protein mS29 Chain: AX
Small ribosomal subunit protein mS31 Chain: AY
Small ribosomal subunit protein mS33 Chain: AZ
Large ribosomal subunit protein uL2m Chain: XD
Large ribosomal subunit protein uL3m Chain: XE
Large ribosomal subunit protein uL4m Chain: XF
Large ribosomal subunit protein bL9m Chain: XH
Large ribosomal subunit protein uL10m Chain: XI
Large ribosomal subunit protein uL11m Chain: XJ
Large ribosomal subunit protein uL13m Chain: XK
Large ribosomal subunit protein uL14m Chain: XL
Large ribosomal subunit protein uL15m Chain: XM
Large ribosomal subunit protein uL16m Chain: XN
Large ribosomal subunit protein bL17m Chain: XO
Large ribosomal subunit protein uL18m Chain: XP
Large ribosomal subunit protein bL19m Chain: XQ
Large ribosomal subunit protein bL20m Chain: XR
Large ribosomal subunit protein bL21m Chain: XS
Large ribosomal subunit protein uL22m Chain: XT
Large ribosomal subunit protein uL23m Chain: XU
Large ribosomal subunit protein uL24m Chain: XV
Large ribosomal subunit protein bL27m Chain: XW
Large ribosomal subunit protein bL28m Chain: XX
Large ribosomal subunit protein uL29m Chain: XY
Large ribosomal subunit protein uL30m Chain: XZ
Large ribosomal subunit protein mL42 Chain: a
Large ribosomal subunit protein mL43 Chain: b
Large ribosomal subunit protein mL44 Chain: c
Large ribosomal subunit protein mL45 Chain: d
Large ribosomal subunit protein mL46 Chain: e
Large ribosomal subunit protein mL48 Chain: f
Large ribosomal subunit protein mL49 Chain: g
Large ribosomal subunit protein mL50 Chain: h
Large ribosomal subunit protein mL51 Chain: i
Large ribosomal subunit protein mL52 Chain: j
Large ribosomal subunit protein mL53 Chain: k
Large ribosomal subunit protein mL54 Chain: l
Large ribosomal subunit protein mL55 Chain: m
Large ribosomal subunit protein mL63 Chain: o
Large ribosomal subunit protein mL62 Chain: p
Large ribosomal subunit protein mL64 Chain: q
Large ribosomal subunit protein mL66 Chain: r
Large ribosomal subunit protein mL65 Chain: s
Large ribosomal subunit protein bL12m Chains: t1, t2, t3, t4, t5, t6
Quinupristin Chain: A
16S mitochondrial rRNA Chain: XA
12S mitochondrial rRNA Chain: AA
mitochondrial tRNAVal Chain: XB
E-site tRNA Chain: r4

Ligands and Environments

2 modified residues:

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-11393