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Crystal structure of death effector domain of Caspase8 in Homo Sapiens

X-ray diffraction
2.2Å resolution
PDB entry 4zbw coloured by chain, front view.
PDB entry 4zbw coloured by chain, side view.
PDB entry 4zbw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Caspase-8 subunit p18
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Multimeric state: homo dimer
Accessible surface area: 20260.99 Å2
Buried surface area: 907.75 Å2
Dissociation area: 453.88 Å2
Dissociation energy (ΔGdiss): -8.36 kcal/mol
Dissociation entropy (TΔSdiss): 12.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172100

Macromolecules

Caspase-8
Chains: A, B
Length: 190 amino acids
Theoretical weight: 22.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14790 (Residues: 2-188; Coverage: 39%)
Gene names: CASP8, MCH5
Pfam: Death effector domain
InterPro:
CATH: Death Domain, Fas
Caspase-8 in PDB entry 4zbw, assembly 1, front view.
Caspase-8 in PDB entry 4zbw, assembly 1, side view.
Caspase-8 in PDB entry 4zbw, assembly 1, top view.
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