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Phosphorylated MAVS in complex with IRF-3

X-ray diffraction
2.4Å resolution
PDB entry 5jek coloured by chain, front view.
PDB entry 5jek coloured by chain, side view.
PDB entry 5jek coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interferon regulatory factor 3 and Mitochondrial antiviral-signaling protein
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Multimeric state: hetero dimer
Accessible surface area: 12419.11 Å2
Buried surface area: 1011.09 Å2
Dissociation area: 505.55 Å2
Dissociation energy (ΔGdiss): 6.2 kcal/mol
Dissociation entropy (TΔSdiss): 8.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172050
Assembly 2
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Assembly Name: Interferon regulatory factor 3 and Mitochondrial antiviral-signaling protein
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Multimeric state: hetero dimer
Accessible surface area: 12691.08 Å2
Buried surface area: 1019.09 Å2
Dissociation area: 509.55 Å2
Dissociation energy (ΔGdiss): 5.97 kcal/mol
Dissociation entropy (TΔSdiss): 8.64 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172050

Macromolecules

Interferon regulatory factor 3
Chains: A, B
Length: 242 amino acids
Theoretical weight: 26.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 189-427; Coverage: 56%)
Gene name: IRF3
Pfam: Interferon-regulatory factor 3
InterPro:
CATH: Tumour Suppressor Smad4
Interferon regulatory factor 3 in PDB entry 5jek, assembly 1, front view.
Interferon regulatory factor 3 in PDB entry 5jek, assembly 1, side view.
Interferon regulatory factor 3 in PDB entry 5jek, assembly 1, top view.
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Mitochondrial antiviral-signaling protein
Chains: C, D
Length: 18 amino acids
Theoretical weight: 1.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z434 (Residues: 433-450; Coverage: 3%)
Gene names: IPS1, KIAA1271, MAVS, VISA
Mitochondrial antiviral-signaling protein in PDB entry 5jek, assembly 1, front view.
Mitochondrial antiviral-signaling protein in PDB entry 5jek, assembly 1, side view.
Mitochondrial antiviral-signaling protein in PDB entry 5jek, assembly 1, top view.
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