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Human pre-Bact-2 spliceosome

Electron Microscopy
8Å resolution
PDB entry 7abi coloured by chain, front view.
PDB entry 7abi coloured by chain, side view.
PDB entry 7abi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 56-mer (preferred)
Entry contents: 45 distinct polypeptide molecules
4 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 56-mer
PDBe Complex ID: PDB-CPX-129048

Macromolecules

U5 small nuclear ribonucleoprotein 40 kDa protein
Chain: D
Length: 357 amino acids
Theoretical weight: 39.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96DI7 (Residues: 1-357; Coverage: 100%)
Gene names: PRP8BP, SFP38, SNRNP40, WDR57
Pfam: WD domain, G-beta repeat
InterPro:
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 7abi, assembly 1, front view.
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 7abi, assembly 1, side view.
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3B subunit 3
Chain: E
Length: 1217 amino acids
Theoretical weight: 135.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15393 (Residues: 1-1217; Coverage: 100%)
Gene names: KIAA0017, SAP130, SF3B3
Pfam:
InterPro:
Splicing factor 3B subunit 3 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3B subunit 3 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3B subunit 3 in PDB entry 7abi, assembly 1, top view.
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Small nuclear ribonucleoprotein F
Chains: b, i
Length: 86 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62306 (Residues: 1-86; Coverage: 100%)
Gene names: PBSCF, SNRPF
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein F in PDB entry 7abi, assembly 1, front view.
Small nuclear ribonucleoprotein F in PDB entry 7abi, assembly 1, side view.
Small nuclear ribonucleoprotein F in PDB entry 7abi, assembly 1, top view.
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U2 small nuclear ribonucleoprotein A'
Chain: W
Length: 255 amino acids
Theoretical weight: 28.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09661 (Residues: 1-255; Coverage: 100%)
Gene name: SNRPA1
Pfam: Leucine-rich repeat
InterPro:
U2 small nuclear ribonucleoprotein A' in PDB entry 7abi, assembly 1, front view.
U2 small nuclear ribonucleoprotein A' in PDB entry 7abi, assembly 1, side view.
U2 small nuclear ribonucleoprotein A' in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3B subunit 4
Chain: w
Length: 424 amino acids
Theoretical weight: 44.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15427 (Residues: 1-424; Coverage: 100%)
Gene names: SAP49, SF3B4
Pfam: RNA recognition motif
InterPro:
Splicing factor 3B subunit 4 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3B subunit 4 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3B subunit 4 in PDB entry 7abi, assembly 1, top view.
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Small nuclear ribonucleoprotein G
Chains: d, k
Length: 76 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62308 (Residues: 1-76; Coverage: 100%)
Gene names: PBSCG, SNRPG
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein G in PDB entry 7abi, assembly 1, front view.
Small nuclear ribonucleoprotein G in PDB entry 7abi, assembly 1, side view.
Small nuclear ribonucleoprotein G in PDB entry 7abi, assembly 1, top view.
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RNA helicase aquarius
Chain: U
Length: 1485 amino acids
Theoretical weight: 171.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60306 (Residues: 1-1485; Coverage: 100%)
Gene names: AQR, KIAA0560
Pfam:
InterPro:
RNA helicase aquarius in PDB entry 7abi, assembly 1, front view.
RNA helicase aquarius in PDB entry 7abi, assembly 1, side view.
RNA helicase aquarius in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3B subunit 5
Chain: x
Length: 86 amino acids
Theoretical weight: 10.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BWJ5 (Residues: 1-86; Coverage: 100%)
Gene names: SF3B10, SF3B5
Pfam: Splicing factor 3B subunit 10 (SF3b10)
InterPro:
Splicing factor 3B subunit 5 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3B subunit 5 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3B subunit 5 in PDB entry 7abi, assembly 1, top view.
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U2 small nuclear ribonucleoprotein B''
Chain: B
Length: 225 amino acids
Theoretical weight: 25.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08579 (Residues: 1-225; Coverage: 100%)
Gene name: SNRPB2
Pfam: RNA recognition motif
InterPro:
U2 small nuclear ribonucleoprotein B'' in PDB entry 7abi, assembly 1, front view.
U2 small nuclear ribonucleoprotein B'' in PDB entry 7abi, assembly 1, side view.
U2 small nuclear ribonucleoprotein B'' in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3B subunit 6
Chain: z
Length: 125 amino acids
Theoretical weight: 14.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3B4 (Residues: 1-125; Coverage: 100%)
Gene names: CGI-110, HSPC175, HT006, SAP14, SF3B14, SF3B14A, SF3B6
Pfam: RNA recognition motif
InterPro:
Splicing factor 3B subunit 6 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3B subunit 6 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3B subunit 6 in PDB entry 7abi, assembly 1, top view.
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Ubiquitin-like protein 5
Chain: q
Length: 73 amino acids
Theoretical weight: 8.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZL1 (Residues: 1-73; Coverage: 100%)
Gene name: UBL5
Pfam: Ubiquitin family
InterPro:
Ubiquitin-like protein 5 in PDB entry 7abi, assembly 1, front view.
Ubiquitin-like protein 5 in PDB entry 7abi, assembly 1, side view.
Ubiquitin-like protein 5 in PDB entry 7abi, assembly 1, top view.
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U5 small nuclear ribonucleoprotein 200 kDa helicase
Chain: s
Length: 2136 amino acids
Theoretical weight: 244.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75643 (Residues: 1-2136; Coverage: 100%)
Gene names: ASCC3L1, BRR2, HELIC2, KIAA0788, SNRNP200
Pfam:
InterPro:
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 7abi, assembly 1, front view.
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 7abi, assembly 1, side view.
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 7abi, assembly 1, top view.
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SNW domain-containing protein 1
Chain: v
Length: 536 amino acids
Theoretical weight: 61.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13573 (Residues: 1-536; Coverage: 100%)
Gene names: SKIIP, SKIP, SNW1
Pfam: SKIP/SNW domain
InterPro:
SNW domain-containing protein 1 in PDB entry 7abi, assembly 1, front view.
SNW domain-containing protein 1 in PDB entry 7abi, assembly 1, side view.
SNW domain-containing protein 1 in PDB entry 7abi, assembly 1, top view.
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BUD13 homolog
Chain: 3
Length: 619 amino acids
Theoretical weight: 70.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BRD0 (Residues: 1-619; Coverage: 100%)
Gene name: BUD13
Pfam: Pre-mRNA-splicing factor of RES complex
InterPro: Bud13
BUD13 homolog in PDB entry 7abi, assembly 1, front view.
BUD13 homolog in PDB entry 7abi, assembly 1, side view.
BUD13 homolog in PDB entry 7abi, assembly 1, top view.
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Smad nuclear-interacting protein 1
Chain: 0
Length: 396 amino acids
Theoretical weight: 45.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TAD8 (Residues: 1-396; Coverage: 100%)
Gene name: SNIP1
Pfam: FHA domain
InterPro:
Smad nuclear-interacting protein 1 in PDB entry 7abi, assembly 1, front view.
Smad nuclear-interacting protein 1 in PDB entry 7abi, assembly 1, side view.
Smad nuclear-interacting protein 1 in PDB entry 7abi, assembly 1, top view.
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Protein BUD31 homolog
Chain: Q
Length: 144 amino acids
Theoretical weight: 17.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P41223 (Residues: 1-144; Coverage: 100%)
Gene names: BUD31, EDG2
Pfam: Pre-mRNA-splicing factor BUD31
InterPro:
Protein BUD31 homolog in PDB entry 7abi, assembly 1, front view.
Protein BUD31 homolog in PDB entry 7abi, assembly 1, side view.
Protein BUD31 homolog in PDB entry 7abi, assembly 1, top view.
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RNA-binding motif protein, X-linked 2
Chain: 1
Length: 322 amino acids
Theoretical weight: 37.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y388 (Residues: 1-322; Coverage: 100%)
Gene names: CGI-79, RBMX2
Pfam: RNA recognition motif
InterPro:
RNA-binding motif protein, X-linked 2 in PDB entry 7abi, assembly 1, front view.
RNA-binding motif protein, X-linked 2 in PDB entry 7abi, assembly 1, side view.
RNA-binding motif protein, X-linked 2 in PDB entry 7abi, assembly 1, top view.
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Cell division cycle 5-like protein
Chain: L
Length: 802 amino acids
Theoretical weight: 92.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99459 (Residues: 1-802; Coverage: 100%)
Gene names: CDC5L, KIAA0432, PCDC5RP
Pfam:
InterPro:
Cell division cycle 5-like protein in PDB entry 7abi, assembly 1, front view.
Cell division cycle 5-like protein in PDB entry 7abi, assembly 1, side view.
Cell division cycle 5-like protein in PDB entry 7abi, assembly 1, top view.
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Zinc finger matrin-type protein 2
Chain: N
Length: 199 amino acids
Theoretical weight: 23.66 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96NC0 (Residues: 1-199; Coverage: 100%)
Gene name: ZMAT2
Pfam: Zinc-finger double-stranded RNA-binding
InterPro:
Zinc finger matrin-type protein 2 in PDB entry 7abi, assembly 1, front view.
Zinc finger matrin-type protein 2 in PDB entry 7abi, assembly 1, side view.
Zinc finger matrin-type protein 2 in PDB entry 7abi, assembly 1, top view.
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Beta-catenin-like protein 1
Chain: S
Length: 563 amino acids
Theoretical weight: 65.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8WYA6 (Residues: 1-563; Coverage: 100%)
Gene names: C20orf33, CTNNBL1, PP8304
Pfam: Catenin-beta-like, Arm-motif containing nuclear
InterPro:
Beta-catenin-like protein 1 in PDB entry 7abi, assembly 1, front view.
Beta-catenin-like protein 1 in PDB entry 7abi, assembly 1, side view.
Beta-catenin-like protein 1 in PDB entry 7abi, assembly 1, top view.
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116 kDa U5 small nuclear ribonucleoprotein component
Chain: r
Length: 972 amino acids
Theoretical weight: 109.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15029 (Residues: 1-972; Coverage: 100%)
Gene names: EFTUD2, KIAA0031, SNRP116
Pfam:
InterPro:
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 7abi, assembly 1, front view.
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 7abi, assembly 1, side view.
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 7abi, assembly 1, top view.
Molecule details ›

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Spliceosome-associated protein CWC15 homolog
Chain: R
Length: 229 amino acids
Theoretical weight: 26.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P013 (Residues: 1-229; Coverage: 100%)
Gene names: AD-002, C11orf5, CWC15, HSPC148
Pfam: Cwf15/Cwc15 cell cycle control protein
InterPro: Pre-mRNA-splicing factor Cwf15/Cwc15
Spliceosome-associated protein CWC15 homolog in PDB entry 7abi, assembly 1, front view.
Spliceosome-associated protein CWC15 homolog in PDB entry 7abi, assembly 1, side view.
Spliceosome-associated protein CWC15 homolog in PDB entry 7abi, assembly 1, top view.
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Serine/arginine repetitive matrix protein 1
Chain: Y
Length: 904 amino acids
Theoretical weight: 102.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8IYB3 (Residues: 1-904; Coverage: 100%)
Gene names: SRM160, SRRM1
Pfam: PWI domain
InterPro:
Serine/arginine repetitive matrix protein 1 in PDB entry 7abi, assembly 1, front view.
Serine/arginine repetitive matrix protein 1 in PDB entry 7abi, assembly 1, side view.
Serine/arginine repetitive matrix protein 1 in PDB entry 7abi, assembly 1, top view.
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DNA/RNA-binding protein KIN17
Chain: 7
Length: 393 amino acids
Theoretical weight: 45.45 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60870 (Residues: 1-393; Coverage: 100%)
Gene names: BTCD, KIN, KIN17
Pfam:
InterPro:
DNA/RNA-binding protein KIN17 in PDB entry 7abi, assembly 1, front view.
DNA/RNA-binding protein KIN17 in PDB entry 7abi, assembly 1, side view.
DNA/RNA-binding protein KIN17 in PDB entry 7abi, assembly 1, top view.
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Pre-mRNA-splicing factor SYF1
Chain: M
Length: 855 amino acids
Theoretical weight: 100.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9HCS7 (Residues: 1-855; Coverage: 100%)
Gene names: HCNP, KIAA1177, PP3898, SYF1, XAB2
Pfam: Tetratricopeptide repeat
InterPro:
Pre-mRNA-splicing factor SYF1 in PDB entry 7abi, assembly 1, front view.
Pre-mRNA-splicing factor SYF1 in PDB entry 7abi, assembly 1, side view.
Pre-mRNA-splicing factor SYF1 in PDB entry 7abi, assembly 1, top view.
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Microfibrillar-associated protein 1
Chain: K
Length: 439 amino acids
Theoretical weight: 52.05 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P55081 (Residues: 1-439; Coverage: 100%)
Gene name: MFAP1
Pfam: Microfibril-associated/Pre-mRNA processing
InterPro:
Microfibrillar-associated protein 1 in PDB entry 7abi, assembly 1, front view.
Microfibrillar-associated protein 1 in PDB entry 7abi, assembly 1, side view.
Microfibrillar-associated protein 1 in PDB entry 7abi, assembly 1, top view.
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Crooked neck-like protein 1
Chain: O
Length: 848 amino acids
Theoretical weight: 100.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZJ0 (Residues: 1-848; Coverage: 100%)
Gene names: CGI-201, CRN, CRNKL1, MSTP021
Pfam: HAT (Half-A-TPR) repeat
InterPro:
Crooked neck-like protein 1 in PDB entry 7abi, assembly 1, front view.
Crooked neck-like protein 1 in PDB entry 7abi, assembly 1, side view.
Crooked neck-like protein 1 in PDB entry 7abi, assembly 1, top view.
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PHD finger-like domain-containing protein 5A
Chain: y
Length: 110 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7RTV0 (Residues: 1-110; Coverage: 100%)
Gene name: PHF5A
Pfam: PHF5-like protein
InterPro: PHF5-like
PHD finger-like domain-containing protein 5A in PDB entry 7abi, assembly 1, front view.
PHD finger-like domain-containing protein 5A in PDB entry 7abi, assembly 1, side view.
PHD finger-like domain-containing protein 5A in PDB entry 7abi, assembly 1, top view.
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Pleiotropic regulator 1
Chain: G
Length: 514 amino acids
Theoretical weight: 57.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43660 (Residues: 1-514; Coverage: 100%)
Gene name: PLRG1
Pfam: WD domain, G-beta repeat
InterPro:
Pleiotropic regulator 1 in PDB entry 7abi, assembly 1, front view.
Pleiotropic regulator 1 in PDB entry 7abi, assembly 1, side view.
Pleiotropic regulator 1 in PDB entry 7abi, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D2
Chains: a, h
Length: 118 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62316 (Residues: 1-118; Coverage: 100%)
Gene names: SNRPD1, SNRPD2
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D2 in PDB entry 7abi, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D2 in PDB entry 7abi, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D2 in PDB entry 7abi, assembly 1, top view.
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Peptidyl-prolyl cis-trans isomerase E
Chain: o
Length: 301 amino acids
Theoretical weight: 33.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UNP9 (Residues: 1-301; Coverage: 100%)
Gene names: CYP33, PPIE
Pfam:
InterPro:
Peptidyl-prolyl cis-trans isomerase E in PDB entry 7abi, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase E in PDB entry 7abi, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase E in PDB entry 7abi, assembly 1, top view.
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RING-type E3 ubiquitin-protein ligase PPIL2
Chain: t
Length: 520 amino acids
Theoretical weight: 58.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13356 (Residues: 1-520; Coverage: 100%)
Gene name: PPIL2
Pfam: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
InterPro:
RING-type E3 ubiquitin-protein ligase PPIL2 in PDB entry 7abi, assembly 1, front view.
RING-type E3 ubiquitin-protein ligase PPIL2 in PDB entry 7abi, assembly 1, side view.
RING-type E3 ubiquitin-protein ligase PPIL2 in PDB entry 7abi, assembly 1, top view.
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Small nuclear ribonucleoprotein-associated proteins B and B'
Chains: f, m
Length: 240 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P14678 (Residues: 1-240; Coverage: 100%)
Gene names: COD, SNRPB, SNRPB1
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 7abi, assembly 1, front view.
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 7abi, assembly 1, side view.
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 7abi, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D3
Chains: e, l
Length: 126 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62318 (Residues: 1-126; Coverage: 100%)
Gene name: SNRPD3
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D3 in PDB entry 7abi, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D3 in PDB entry 7abi, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D3 in PDB entry 7abi, assembly 1, top view.
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Pre-mRNA-processing-splicing factor 8
Chain: A
Length: 2335 amino acids
Theoretical weight: 273.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P2Q9 (Residues: 1-2335; Coverage: 100%)
Gene names: PRPC8, PRPF8
Pfam:
InterPro:
Pre-mRNA-processing-splicing factor 8 in PDB entry 7abi, assembly 1, front view.
Pre-mRNA-processing-splicing factor 8 in PDB entry 7abi, assembly 1, side view.
Pre-mRNA-processing-splicing factor 8 in PDB entry 7abi, assembly 1, top view.
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Pre-mRNA-processing factor 17
Chain: 8
Length: 579 amino acids
Theoretical weight: 65.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O60508 (Residues: 1-579; Coverage: 100%)
Gene names: CDC40, EHB3, PRP17, PRPF17
Pfam: WD domain, G-beta repeat
InterPro:
Pre-mRNA-processing factor 17 in PDB entry 7abi, assembly 1, front view.
Pre-mRNA-processing factor 17 in PDB entry 7abi, assembly 1, side view.
Pre-mRNA-processing factor 17 in PDB entry 7abi, assembly 1, top view.
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Small nuclear ribonucleoprotein E
Chains: c, j
Length: 92 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62304 (Residues: 1-92; Coverage: 100%)
Gene name: SNRPE
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein E in PDB entry 7abi, assembly 1, front view.
Small nuclear ribonucleoprotein E in PDB entry 7abi, assembly 1, side view.
Small nuclear ribonucleoprotein E in PDB entry 7abi, assembly 1, top view.
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Pre-mRNA-splicing factor 38A
Chain: I
Length: 312 amino acids
Theoretical weight: 37.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8NAV1 (Residues: 1-312; Coverage: 100%)
Gene name: PRPF38A
Pfam:
InterPro:
Pre-mRNA-splicing factor 38A in PDB entry 7abi, assembly 1, front view.
Pre-mRNA-splicing factor 38A in PDB entry 7abi, assembly 1, side view.
Pre-mRNA-splicing factor 38A in PDB entry 7abi, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D1
Chains: g, n
Length: 119 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62314 (Residues: 1-119; Coverage: 100%)
Gene name: SNRPD1
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D1 in PDB entry 7abi, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D1 in PDB entry 7abi, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D1 in PDB entry 7abi, assembly 1, top view.
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Pre-mRNA-splicing factor RBM22
Chain: P
Length: 420 amino acids
Theoretical weight: 46.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NW64 (Residues: 1-420; Coverage: 100%)
Gene names: 199G4, RBM22, ZC3H16
Pfam:
InterPro:
Pre-mRNA-splicing factor RBM22 in PDB entry 7abi, assembly 1, front view.
Pre-mRNA-splicing factor RBM22 in PDB entry 7abi, assembly 1, side view.
Pre-mRNA-splicing factor RBM22 in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3A subunit 1
Chain: p
Length: 793 amino acids
Theoretical weight: 88.99 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15459 (Residues: 1-793; Coverage: 100%)
Gene names: SAP114, SF3A1
Pfam:
InterPro:
Splicing factor 3A subunit 1 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3A subunit 1 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3A subunit 1 in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3A subunit 2
Chain: F
Length: 464 amino acids
Theoretical weight: 49.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15428 (Residues: 1-464; Coverage: 100%)
Gene names: SAP62, SF3A2
Pfam:
InterPro:
Splicing factor 3A subunit 2 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3A subunit 2 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3A subunit 2 in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3A subunit 3
Chain: 4
Length: 501 amino acids
Theoretical weight: 58.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q12874 (Residues: 1-501; Coverage: 100%)
Gene names: SAP61, SF3A3
Pfam:
InterPro:
Splicing factor 3A subunit 3 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3A subunit 3 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3A subunit 3 in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3B subunit 1
Chain: u
Length: 1304 amino acids
Theoretical weight: 146.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75533 (Residues: 1-1304; Coverage: 100%)
Gene names: SAP155, SF3B1
Pfam:
InterPro:
Splicing factor 3B subunit 1 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3B subunit 1 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3B subunit 1 in PDB entry 7abi, assembly 1, top view.
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Splicing factor 3B subunit 2
Chain: T
Length: 895 amino acids
Theoretical weight: 100.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13435 (Residues: 1-895; Coverage: 100%)
Gene names: SAP145, SF3B2
Pfam:
InterPro:
Splicing factor 3B subunit 2 in PDB entry 7abi, assembly 1, front view.
Splicing factor 3B subunit 2 in PDB entry 7abi, assembly 1, side view.
Splicing factor 3B subunit 2 in PDB entry 7abi, assembly 1, top view.
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RNA chain 6
Name: U6 snRNA
Representative chains: 6
Length: 106 nucleotides
Theoretical weight: 34.1 KDa
Rfam: U6 spliceosomal RNA
U6 snRNA in PDB entry 7abi, assembly 1, front view.
U6 snRNA in PDB entry 7abi, assembly 1, side view.
U6 snRNA in PDB entry 7abi, assembly 1, top view.
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RNA chain 2
Name: U2 snRNA
Representative chains: 2
Length: 188 nucleotides
Theoretical weight: 60.19 KDa
Rfam: U2 spliceosomal RNA
U2 snRNA in PDB entry 7abi, assembly 1, front view.
U2 snRNA in PDB entry 7abi, assembly 1, side view.
U2 snRNA in PDB entry 7abi, assembly 1, top view.
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RNA chain Z
Name: MINX M3 pre-mRNA
Representative chains: Z
Length: 324 nucleotides
Theoretical weight: 103.96 KDa
MINX M3 pre-mRNA in PDB entry 7abi, assembly 1, front view.
MINX M3 pre-mRNA in PDB entry 7abi, assembly 1, side view.
MINX M3 pre-mRNA in PDB entry 7abi, assembly 1, top view.
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RNA chain 5
Name: U5 snRNA
Representative chains: 5
Length: 116 nucleotides
Theoretical weight: 36.91 KDa
Rfam: U5 spliceosomal RNA
U5 snRNA in PDB entry 7abi, assembly 1, front view.
U5 snRNA in PDB entry 7abi, assembly 1, side view.
U5 snRNA in PDB entry 7abi, assembly 1, top view.
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