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Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI

Electron Microscopy
3.7Å resolution
PDB entry 7ay1 coloured by chain, front view.
PDB entry 7ay1 coloured by chain, side view.
PDB entry 7ay1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero heptamer (preferred)
Entry contents: 5 distinct polypeptide molecules
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fanconi anemia ID complex and DNA
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Multimeric state: hetero heptamer
PDBe Complex ID: PDB-CPX-121090

Macromolecules

Fanconi anemia group I protein
Chain: A
Length: 1335 amino acids
Theoretical weight: 150.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NVI1 (Residues: 1-1328; Coverage: 100%)
Gene names: FANCI, KIAA1794
Pfam:
InterPro:
Fanconi anemia group I protein in PDB entry 7ay1, assembly 1, front view.
Fanconi anemia group I protein in PDB entry 7ay1, assembly 1, side view.
Fanconi anemia group I protein in PDB entry 7ay1, assembly 1, top view.
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Fanconi anemia group D2 protein
Chain: B
Length: 1455 amino acids
Theoretical weight: 164.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BXW9 (Residues: 1-1451; Coverage: 100%)
Gene names: FACD, FANCD2
Pfam: Fanconi anaemia protein FancD2 nuclease
InterPro: Fanconi anaemia protein FANCD2
Fanconi anemia group D2 protein in PDB entry 7ay1, assembly 1, front view.
Fanconi anemia group D2 protein in PDB entry 7ay1, assembly 1, side view.
Fanconi anemia group D2 protein in PDB entry 7ay1, assembly 1, top view.
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Ubiquitin
Chain: C
Length: 80 amino acids
Theoretical weight: 8.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62987 (Residues: 1-76; Coverage: 59%)
Gene names: UBA52, UBCEP2
Pfam: Ubiquitin family
InterPro:
Ubiquitin in PDB entry 7ay1, assembly 1, front view.
Ubiquitin in PDB entry 7ay1, assembly 1, side view.
Ubiquitin in PDB entry 7ay1, assembly 1, top view.
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Ubiquitin carboxyl-terminal hydrolase 1
Chain: D
Length: 786 amino acids
Theoretical weight: 88.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O94782 (Residues: 1-785; Coverage: 100%)
Gene name: USP1
Pfam: Ubiquitin carboxyl-terminal hydrolase
InterPro:
Ubiquitin carboxyl-terminal hydrolase 1 in PDB entry 7ay1, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase 1 in PDB entry 7ay1, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase 1 in PDB entry 7ay1, assembly 1, top view.
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WD repeat-containing protein 48
Chain: E
Length: 694 amino acids
Theoretical weight: 78.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TAF3 (Residues: 1-677; Coverage: 100%)
Gene names: KIAA1449, UAF1, WDR48
Pfam:
InterPro:
WD repeat-containing protein 48 in PDB entry 7ay1, assembly 1, front view.
WD repeat-containing protein 48 in PDB entry 7ay1, assembly 1, side view.
WD repeat-containing protein 48 in PDB entry 7ay1, assembly 1, top view.
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DNA chains S, T
Name: DNA (61-MER)
Representative chains: S, T
Length: 29 nucleotides
Theoretical weight: 5.18 KDa
DNA (61-MER) in PDB entry 7ay1, assembly 1, front view.
DNA (61-MER) in PDB entry 7ay1, assembly 1, side view.
DNA (61-MER) in PDB entry 7ay1, assembly 1, top view.
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