7dgs

Electron Microscopy
7.8Å resolution

Activity optimized supercomplex state3

Released:
Source organism: Bos taurus
Related structures: EMD-30675

Function and Biology Details

Reactions catalysed:
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 80-mer (preferred)
PDBe Complex ID:
PDB-CPX-132191 (preferred)
Entry contents:
68 distinct polypeptide molecules
Macromolecules (68 distinct):
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Chain: 9
Molecule details ›
Chain: 9
Length: 217 amino acids
Theoretical weight: 23.84 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P04394 (Residues: 33-249; Coverage: 87%)
Gene name: NDUFV2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
NADH-ubiquinone oxidoreductase chain 6 Chain: 7
Molecule details ›
Chain: 7
Length: 175 amino acids
Theoretical weight: 19.08 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P03924 (Residues: 1-175; Coverage: 100%)
Gene names: MT-ND6, MTND6, NADH6, ND6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
NADH-ubiquinone oxidoreductase chain 5 Chain: 6
NADH-ubiquinone oxidoreductase chain 2 Chain: 2
NADH-ubiquinone oxidoreductase chain 4 Chain: 4
NADH-ubiquinone oxidoreductase chain 4L Chain: 5
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chain: 8
NADH-ubiquinone oxidoreductase chain 1 Chain: 1
NADH-ubiquinone oxidoreductase chain 3 Chain: 3
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Chain: A
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Chain: B
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Chain: C
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Chain: D
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Chain: E
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Chain: F
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chain: G
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Chain: H
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Chain: I
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chain: J
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Chain: K
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Chain: L
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Chain: N
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Chain: O
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Chain: P
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Chain: Q
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Chain: R
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Chain: S
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Chain: T
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Chain: U
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chain: V
Acyl carrier protein, mitochondrial Chains: M, W
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Chain: X
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Chain: Y
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Chain: Z
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Chain: a
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Chain: b
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Chain: c
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Chain: d
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chain: f
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Chain: h
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Chain: i
NADH dehydrogenase [ubiquinone] 1 subunit C2 Chain: j
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Chain: g
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Chain: e
Cytochrome b-c1 complex subunit 1, mitochondrial Chains: k, w
Cytochrome b-c1 complex subunit 2, mitochondrial Chains: l, x
Cytochrome b Chains: m, y
Cytochrome c1, heme protein, mitochondrial Chains: o, z
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chains: A0, p
Cytochrome b-c1 complex subunit 7 Chains: A1, q
Cytochrome b-c1 complex subunit 8 Chains: A2, r
Cytochrome b-c1 complex subunit 6, mitochondrial Chains: B5, s
Cytochrome b-c1 complex subunit 10 Chains: A3, t
Cytochrome b-c1 complex subunit 9 Chains: B4, u
Cytochrome b-c1 complex subunit 9 Chains: B3, v
Cytochrome c oxidase subunit 1 Chain: A9
Cytochrome c oxidase subunit 2 Chain: B9
Cytochrome c oxidase subunit 3 Chain: B7
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Chain: A7
Cytochrome c oxidase subunit 5A, mitochondrial Chain: A6
Cytochrome c oxidase subunit 5B, mitochondrial Chain: B2
Cytochrome c oxidase subunit 6A2, mitochondrial Chain: A4
Cytochrome c oxidase subunit 6B1 Chain: A5
Cytochrome c oxidase subunit 6C Chain: B6
Cytochrome c oxidase subunit 7A1, mitochondrial Chain: B8
Cytochrome c oxidase subunit 7B, mitochondrial Chain: B0
Cytochrome c oxidase subunit 7C, mitochondrial Chain: B1
Cytochrome c oxidase subunit 8B, mitochondrial Chain: A8

Ligands and Environments

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 7.8Å
Relevant EMDB volumes: EMD-30675