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Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25

Electron Microscopy
3.81Å resolution
PDB entry 7m30 coloured by chain, front view.
PDB entry 7m30 coloured by chain, side view.
PDB entry 7m30 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero decamer (preferred)
Entry contents: 10 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero decamer
Accessible surface area: 54275.11 Å2
Buried surface area: 21536.11 Å2
Dissociation area: 2,142.88 Å2
Dissociation energy (ΔGdiss): -17.66 kcal/mol
Dissociation entropy (TΔSdiss): 40.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-207854

Macromolecules

Envelope glycoprotein L
Chain: B
Length: 248 amino acids
Theoretical weight: 27.66 KDa
Source organism: Human betaherpesvirus 5
Expression system: Homo sapiens
UniProt:
  • Canonical: P16832 (Residues: 31-278; Coverage: 100%)
Gene names: UL115, gL
Pfam: Cytomegalovirus glycoprotein L
InterPro: Cytomegalovirus glycoprotein L
Envelope glycoprotein L in PDB entry 7m30, assembly 1, front view.
Envelope glycoprotein L in PDB entry 7m30, assembly 1, side view.
Envelope glycoprotein L in PDB entry 7m30, assembly 1, top view.
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Uncharacterized protein UL128
Chain: C
Length: 144 amino acids
Theoretical weight: 16.68 KDa
Source organism: Human betaherpesvirus 5
Expression system: Homo sapiens
UniProt:
  • Canonical: P16837 (Residues: 28-171; Coverage: 84%)
Gene name: UL128
Uncharacterized protein UL128 in PDB entry 7m30, assembly 1, front view.
Uncharacterized protein UL128 in PDB entry 7m30, assembly 1, side view.
Uncharacterized protein UL128 in PDB entry 7m30, assembly 1, top view.
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Uncharacterized protein UL130
Chain: D
Length: 189 amino acids
Theoretical weight: 21.76 KDa
Source organism: Human betaherpesvirus 5
Expression system: Homo sapiens
UniProt:
  • Canonical: P16772 (Residues: 26-214; Coverage: 88%)
Gene name: UL130
Pfam: HCMV glycoprotein pUL130
InterPro: Herpesvirus UL130, cytomegalovirus
Uncharacterized protein UL130 in PDB entry 7m30, assembly 1, front view.
Uncharacterized protein UL130 in PDB entry 7m30, assembly 1, side view.
Uncharacterized protein UL130 in PDB entry 7m30, assembly 1, top view.
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Protein UL131A
Chain: E
Length: 111 amino acids
Theoretical weight: 13.01 KDa
Source organism: Human betaherpesvirus 5
Expression system: Homo sapiens
UniProt:
  • Canonical: F5HET4 (Residues: 19-129; Coverage: 100%)
Gene name: UL131A
Protein UL131A in PDB entry 7m30, assembly 1, front view.
Protein UL131A in PDB entry 7m30, assembly 1, side view.
Protein UL131A in PDB entry 7m30, assembly 1, top view.
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2-25 Fab Heavy Chain
Chain: F
Length: 234 amino acids
Theoretical weight: 25.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
2-25 Fab Heavy Chain in PDB entry 7m30, assembly 1, front view.
2-25 Fab Heavy Chain in PDB entry 7m30, assembly 1, side view.
2-25 Fab Heavy Chain in PDB entry 7m30, assembly 1, top view.
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2-25 Fab Light Chain
Chain: G
Length: 212 amino acids
Theoretical weight: 22.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
2-25 Fab Light Chain in PDB entry 7m30, assembly 1, front view.
2-25 Fab Light Chain in PDB entry 7m30, assembly 1, side view.
2-25 Fab Light Chain in PDB entry 7m30, assembly 1, top view.
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1-32 Fab Heavy Chain
Chain: H
Length: 241 amino acids
Theoretical weight: 26.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
1-32 Fab Heavy Chain in PDB entry 7m30, assembly 1, front view.
1-32 Fab Heavy Chain in PDB entry 7m30, assembly 1, side view.
1-32 Fab Heavy Chain in PDB entry 7m30, assembly 1, top view.
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1-32 Fab Light Chain
Chain: L
Length: 213 amino acids
Theoretical weight: 23.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
1-32 Fab Light Chain in PDB entry 7m30, assembly 1, front view.
1-32 Fab Light Chain in PDB entry 7m30, assembly 1, side view.
1-32 Fab Light Chain in PDB entry 7m30, assembly 1, top view.
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1-103 Fab Heavy Chain
Chain: M
Length: 232 amino acids
Theoretical weight: 24.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
1-103 Fab Heavy Chain in PDB entry 7m30, assembly 1, front view.
1-103 Fab Heavy Chain in PDB entry 7m30, assembly 1, side view.
1-103 Fab Heavy Chain in PDB entry 7m30, assembly 1, top view.
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1-103 Fab Light Chain
Chain: N
Length: 210 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
1-103 Fab Light Chain in PDB entry 7m30, assembly 1, front view.
1-103 Fab Light Chain in PDB entry 7m30, assembly 1, side view.
1-103 Fab Light Chain in PDB entry 7m30, assembly 1, top view.
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