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Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab

Electron Microscopy
3.45Å resolution
PDB entry 7mn8 coloured by chain, front view.
PDB entry 7mn8 coloured by chain, side view.
PDB entry 7mn8 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 75685.54 Å2
Buried surface area: 14381.12 Å2
Dissociation area: 872.89 Å2
Dissociation energy (ΔGdiss): -3.39 kcal/mol
Dissociation entropy (TΔSdiss): 15.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209111

Macromolecules

Receptor tyrosine-protein kinase erbB-3
Chain: A
Length: 1066 amino acids
Theoretical weight: 117.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P21860 (Residues: 1-1021; Coverage: 76%)
  • Best match: P21860-3 (Residues: 1-330)
Gene names: ERBB3, HER3
Pfam:
InterPro:
Receptor tyrosine-protein kinase erbB-3 in PDB entry 7mn8, assembly 1, front view.
Receptor tyrosine-protein kinase erbB-3 in PDB entry 7mn8, assembly 1, side view.
Receptor tyrosine-protein kinase erbB-3 in PDB entry 7mn8, assembly 1, top view.
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Neuregulin-1
Chain: H
Length: 87 amino acids
Theoretical weight: 9.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02297 (Residues: 176-237; Coverage: 10%)
  • Best match: Q02297-8 (Residues: 176-230)
Gene names: GGF, HGL, HRGA, NDF, NRG1, SMDF
Pfam: EGF-like domain
InterPro:
Neuregulin-1 in PDB entry 7mn8, assembly 1, front view.
Neuregulin-1 in PDB entry 7mn8, assembly 1, side view.
Neuregulin-1 in PDB entry 7mn8, assembly 1, top view.
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Maltose/maltodextrin-binding periplasmic protein; Receptor tyrosine-protein kinase erbB-2
Chain: B
Length: 1455 amino acids
Theoretical weight: 160.56 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P04626 (Residues: 1-1029; Coverage: 82%)
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
    • nullnull
Gene names: ERBB2, HER2, JW3994, MLN19, NEU, NGL, b4034, malE
Pfam:
InterPro:
Maltose/maltodextrin-binding periplasmic protein in PDB entry 7mn8, assembly 1, front view.
Maltose/maltodextrin-binding periplasmic protein in PDB entry 7mn8, assembly 1, side view.
Maltose/maltodextrin-binding periplasmic protein in PDB entry 7mn8, assembly 1, top view.
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Trastuzumab Fab Light Chain
Chain: C
Length: 225 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
Trastuzumab Fab Light Chain in PDB entry 7mn8, assembly 1, front view.
Trastuzumab Fab Light Chain in PDB entry 7mn8, assembly 1, side view.
Trastuzumab Fab Light Chain in PDB entry 7mn8, assembly 1, top view.
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Trastuzumab Fab Heavy Chain
Chain: D
Length: 237 amino acids
Theoretical weight: 25.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
Trastuzumab Fab Heavy Chain in PDB entry 7mn8, assembly 1, front view.
Trastuzumab Fab Heavy Chain in PDB entry 7mn8, assembly 1, side view.
Trastuzumab Fab Heavy Chain in PDB entry 7mn8, assembly 1, top view.
Molecule details ›

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