Assemblies
Multimeric state:
hetero pentamer
Accessible surface area:
75685.54 Å2
Buried surface area:
14381.12 Å2
Dissociation area:
872.89
Å2
Dissociation energy (ΔGdiss):
-3.39
kcal/mol
Dissociation entropy (TΔSdiss):
15.05
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-209111
Macromolecules
Chain: A
Length: 1066 amino acids
Theoretical weight: 117.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt: Gene names: ERBB3, HER3
Pfam:
Length: 1066 amino acids
Theoretical weight: 117.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt: Gene names: ERBB3, HER3
Pfam:
- Receptor L domain
- Furin-like cysteine rich region
- Growth factor receptor domain IV
- Protein tyrosine and serine/threonine kinase
- Tyrosine protein kinase, EGF/ERB/XmrK receptor
- Receptor L-domain superfamily
- Receptor L-domain
- Growth factor receptor cysteine-rich domain superfamily
- Furin-like repeat
- Furin-like cysteine-rich domain
- Growth factor receptor domain 4
- Protein kinase-like domain superfamily
- Protein kinase domain
- Serine-threonine/tyrosine-protein kinase, catalytic domain
Chain: H
Length: 87 amino acids
Theoretical weight: 9.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: Gene names: GGF, HGL, HRGA, NDF, NRG1, SMDF
Pfam: EGF-like domain
InterPro:
Length: 87 amino acids
Theoretical weight: 9.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: Gene names: GGF, HGL, HRGA, NDF, NRG1, SMDF
Pfam: EGF-like domain
InterPro:
Chain: B
Length: 1455 amino acids
Theoretical weight: 160.56 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
Pfam:
Length: 1455 amino acids
Theoretical weight: 160.56 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
- Canonical:
P04626 (Residues: 1-1029; Coverage: 82%)
- Canonical:
P0AEX9 (Residues: 27-392; Coverage: 99%)
nullnull
Pfam:
- Receptor L domain
- Furin-like cysteine rich region
- Growth factor receptor domain IV
- Protein tyrosine and serine/threonine kinase
- Epidermal growth factor receptor transmembrane-juxtamembrane segment
- Bacterial extracellular solute-binding protein
- Receptor L-domain superfamily
- Receptor L-domain
- Growth factor receptor cysteine-rich domain superfamily
- Furin-like repeat
- Furin-like cysteine-rich domain
- Growth factor receptor domain 4
- Protein kinase-like domain superfamily
- Protein kinase domain
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- Tyrosine-protein kinase, catalytic domain
- Protein kinase, ATP binding site
- Tyrosine-protein kinase, active site
- Maltose/Cyclodextrin ABC transporter, substrate-binding protein
- Bacterial-type extracellular solute-binding protein
- Solute-binding family 1, conserved site
Chain: C
Length: 225 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 225 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Chain: D
Length: 237 amino acids
Theoretical weight: 25.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Length: 237 amino acids
Theoretical weight: 25.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens