EC 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating)
Reaction catalysed:
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Systematic name:
NADH:ubiquinone oxidoreductase
Alternative Name(s):
- Coenzyme Q reductase
- Complex 1 dehydrogenase
- Complex I (NADH:Q1 oxidoreductase)
- Complex I (electron transport chain)
- Complex I (mitochondrial electron transport)
- DPNH-coenzyme Q reductase
- DPNH-ubiquinone reductase
- Dihydronicotinamide adenine dinucleotide-coenzyme Q reductase
- Electron transfer complex I
- Mitochondrial electron transport complex 1
- Mitochondrial electron transport complex I
- NADH coenzyme Q1 reductase
- NADH dehydrogenase (ubiquinone)
- NADH-CoQ oxidoreductase
- NADH-CoQ reductase
- NADH-Q6 oxidoreductase
- NADH-coenzyme Q oxidoreductase
- NADH-coenzyme Q reductase
- NADH-ubiquinone oxidoreductase
- NADH-ubiquinone reductase
- NADH-ubiquinone-1 reductase
- NADH:ubiquinone oxidoreductase complex
- Reduced nicotinamide adenine dinucleotide-coenzyme Q reductase
- Type 1 dehydrogenase
- Ubiquinone reductase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
PF15880
Domain description:
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF15880 (NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial)</span> in <span class='highlight'>NADH:ubiquinone oxidoreductase subunit V3</span>. Showing 1 copy in chain <span class='highlight'>SA [auth 1s]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF15880 (NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial) in NADH:ubiquinone oxidoreductase subunit V3. Showing 1 copy in chain SA [auth 1s].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_44_1s_Pfam_PF15880_image-200x200.png)
PF07347
Domain description:
NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF07347 (NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a))</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</span>. Showing 1 copy in chain <span class='highlight'>RA [auth 1r]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF07347 (NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)) in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7. Showing 1 copy in chain RA [auth 1r].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_43_1r_Pfam_PF07347_image-200x200.png)
PF05821
Domain description:
NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF05821 (NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8))</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>LA [auth 1l]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF05821 (NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)) in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial. Showing 1 copy in chain LA [auth 1l].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_37_1l_Pfam_PF05821_image-200x200.png)
PF10183
Domain description:
ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF10183 (ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) )</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>GA [auth 1g]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF10183 (ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) ) in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial. Showing 1 copy in chain GA [auth 1g].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_32_1g_Pfam_PF10183_image-200x200.png)
PF15088
Domain description:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF15088 (NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial)</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>CA [auth 1c]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF15088 (NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial) in NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial. Showing 1 copy in chain CA [auth 1c].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_28_1c_Pfam_PF15088_image-200x200.png)
PF00662
Domain description:
NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF00662 (NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus)</span> in <span class='highlight'>NADH-ubiquinone oxidoreductase chain 5</span>. Showing 1 copy in chain <span class='highlight'>L [auth 1L]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF00662 (NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus) in NADH-ubiquinone oxidoreductase chain 5. Showing 1 copy in chain L [auth 1L].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_12_1L_Pfam_PF00662_image-200x200.png)
PF22151
Domain description:
NADH-ubiquinone oxidoreductase NDSU1/NuoG-like, 4Fe-4S domain
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF22151 (NADH-ubiquinone oxidoreductase NDSU1/NuoG-like, 4Fe-4S domain)</span> in <span class='highlight'>NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>G [auth 1G]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF22151 (NADH-ubiquinone oxidoreductase NDSU1/NuoG-like, 4Fe-4S domain) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G [auth 1G].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_7_1G_Pfam_PF22151_image-200x200.png)
PF22117
Domain description:
NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF22117 (NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain)</span> in <span class='highlight'>NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>G [auth 1G]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF22117 (NADH-quinone oxidoreductase subunit 3, ferredoxin-like domain) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G [auth 1G].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_7_1G_Pfam_PF22117_image-200x200.png)
PF10588
Domain description:
NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region)</span> in <span class='highlight'>NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>G [auth 1G]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region) in NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. Showing 1 copy in chain G [auth 1G].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_7_1G_Pfam_PF10588_image-200x200.png)
PF10589
Domain description:
NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Occurring in:
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>8uex</span> contains 1 copy of Pfam domain <span class='highlight'>PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region)</span> in <span class='highlight'>NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</span>. Showing 1 copy in chain <span class='highlight'>F [auth 1F]</span>. The deposited structure of PDB entry 8uex contains 1 copy of Pfam domain PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region) in NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial. Showing 1 copy in chain F [auth 1F].](https://www.ebi.ac.uk/pdbe/static/entry/8uex_6_1F_Pfam_PF10589_image-200x200.png)