Summary for peptidase A01.041: BACE2 g.p. (Homo sapiens)

Names
MEROPS Name	BACE2 g.p. (Homo sapiens)
Other names	ALP56 protein, Asp1 protease, beta-secretase (putative), beta-site APP-cleaving enzyme 2, breast-cancer-related aspartic proteinase, Down region aspartic protease, DRAP, memapsin-1

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.041
Holotype	BACE2 g.p. (Homo sapiens), Uniprot accession Q9Y5Z0 (peptidase unit: 69-441), MERNUM MER0005534
History	Identifier created: MEROPS 3.4 (5 November 1999)

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00023
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.45
Enzymology	BRENDA database
Proteolytic events	CutDB database (3 cleavages)
Activity status	human: active (Tang & Koelsch, 2004) mouse: putative
Pharmaceutical relevance	Candidate beta-secretase in Alzheimer"s disease (together with memapsin 2). The gene maps to chromosome 21 in the so-called "Down critical region" in 21q22.3 (Acquati et al., 2000). Reported to show differential expression in human breast cancer (Xin et al., 2000).
Pathways	KEGG	Alzheimer's disease
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/BACE2
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	g/-/-/--/-/-/- (based on 33 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	7	1	1	3	4	2	2	3
Pro	0	1	1	1	1	2	0	2
Ala	3	4	4	1	6	3	2	2
Val	5	5	4	0	1	2	3	2
Leu	3	5	6	7	2	5	2	5
Ile	2	1	0	0	0	0	1	1
Met	1	0	1	1	0	0	0	1
Phe	0	0	2	2	4	1	4	5
Tyr	1	0	0	3	2	3	4	2
Trp	0	0	0	0	0	0	0	0
Ser	0	1	2	1	1	0	1	0
Thr	0	0	0	0	0	0	0	1
Cys	0	0	0	0	0	0	0	0
Asn	0	1	1	0	0	0	0	0
Gln	0	0	1	1	1	1	0	0
Asp	0	1	0	1	1	1	1	2
Glu	4	5	0	2	0	4	3	0
Lys	2	2	2	3	4	5	3	0
Arg	1	2	4	4	3	4	1	1
His	2	3	3	3	3	0	1	0