Sequence features for peptidase A01.041: BACE2 g.p. (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Source
MER0689968 Acanthisitta chloris 414 1-337 D6, Y45, D199, GENBANK:XP_009073603
MER0204797 Ailuropoda melanoleuca 415 1-338 D7, Y46, D200 UNIPROT:D2I4Z1
MER0204797 Ailuropoda melanoleuca 415 1-338 D7, Y46, D200 UNIPROT:D2I4Z1
MER0497145 Alligator mississippiensis 427 14-350 D19, Y58, D212 GENBANK:XP_006273818
MER0497083 Alligator sinensis 398 9-321 D15, Y54, D183 GENBANK:XP_006033656
MER0427810 Anas platyrhynchos 454 30-365 D46, Y85, D239 GENBANK:XP_005009345
MER0686025 Apaloderma vittatum 414 1-337 D6, Y45, D199 GENBANK:XP_009877106
MER0687107 Aptenodytes forsteri 429 14-352 D21, Y60, D214 GENBANK:XP_009281366
MER0685325 Aquila chrysaetos 471 56-394 D63, Y102, D256 GENBANK:XP_011586699
MER0394100 Balaenoptera acutorostrata 424 11-347 D16, Y55, D209 GENBANK:XP_007172812
MER0678916 Balearica regulorum 343 12-343 D19, Y58, D212 GENBANK:XP_010304853
MER0679217 Bison bison 605 163-528 D197, Y236, D390 GENBANK:XP_010833315
MER0429354 Bos grunniens 473 48-384 D66, Y105, D258 UNIPROT:L8IT34
MER0429354 Bos grunniens 473 48-384 D66, Y105, D258 UNIPROT:L8IT34
MER0581229 Bubalus bubalis 556 114-479 D148, Y187, D341 GENBANK:XP_006077012
MER0383756 Callithrix jacchus 452 81-418 D99, Y138, D292 GENBANK:XP_002761485
MER0582275 Calypte anna 425 12-348 D17, Y56, D210 GENBANK:XP_008495450
MER0677816 Camelus dromedarius 439 1-362 D31, Y70, D224 GENBANK:XP_010990700
MER0430343 Camelus ferus 316 27-271 missing, Y41, D195 UNIPROT:S9Y1Q3
MER0430343 Camelus ferus 316 27-271 missing, Y41, D195 UNIPROT:S9Y1Q3
MER0497121 Camelus ferus 461 48-384 D53, Y92, D246 GENBANK:XP_006189079
MER0087982 Canis lupus familiaris 422 8-345 D14, Y53, D207 GENBANK:XP_535595
MER0496921 Capra hircus 420 6-343 D12, Y51, D205 GENBANK:XP_005675801
MER0430002 Ceratotherium simum 439 13-350 D31, Y70, D224 GENBANK:XP_004429676
MER0585622 Cercopithecus sabaeus 518 76-441 D110, Y149, D303 GENBANK:XP_007966750
MER0585623 Cercopithecus sabaeus 468 76-383 D110, Y149, D303 GENBANK:XP_007966758
MER0672177 Charadrius vociferus 454 39-377 D46, Y85, D239 GENBANK:XP_009889672
MER0591348 Chelonia mydas 439 25-362 D31, Y70, D224 GENBANK:XP_007064531
MER0429369 Chinchilla lanigera 414 13-325 D31, Y70, D199 GENBANK:XP_005375908
MER0429951 Chrysemys picta 509 83-420 D101, Y140, D294 GENBANK:XP_005304510
MER0575556 Chrysochloris asiatica 518 76-441 D110, Y149, D303 GENBANK:XP_006870896
MER0671279 Colius striatus 383 53-383 D59, Y98, D252 GENBANK:XP_010205525
MER0670637 Colobus angolensis 439 1-362 D31, Y70, D224 GENBANK:XP_011809446
MER0425887 Columba livia 416 1-327 D8, Y47, D201 UNIPROT:R7VY72
MER0425887 Columba livia 416 1-327 D8, Y47, D201 UNIPROT:R7VY72
MER0496868 Condylura cristata 531 1-457 K25, Y32, missing GENBANK:XP_004695941
MER0572585 Corvus brachyrhynchos 414 1-337 D6, Y45, D199 GENBANK:XP_008628815
MER0667960 Corvus cornix 427 14-350 D19, Y58, D212 GENBANK:XP_010393046
MER0383897 Cricetulus griseus 463 47-374 D55, Y94, D248 GENBANK:XP_003502690
MER0664993 Cuculus canorus 485 68-410 D79, Y118, D272 GENBANK:XP_009559209
MER0567134 Cynoglossus semilaevis 491 59-418 D100, Y139, D285 GENBANK:XP_008306679
MER0155818 Danio rerio 372 64-372 D98, Y137, D292 GENBANK:NP_001005991
MER0106835 Echinops telfairi 517 91-428 D109, Y148, D302 GENBANK:XP_004696976
MER0664740 Egretta garzetta 439 17-362 D31, Y70, D224 GENBANK:XP_009639216
MER0430271 Eimeria brunetti 310 1-284 D3, A46, N173 UNIPROT:U6LGM0
MER0430271 Eimeria brunetti 310 1-284 D3, A46, N173 UNIPROT:U6LGM0
MER0564859 Elephantulus edwardii 515 76-438 D107, Y146, D300 GENBANK:XP_006886770
MER0563858 Eptesicus fuscus 486 41-409 D78, Y117, D271 GENBANK:XP_008144004
MER0496914 Equus caballus 610 165-533 D202, Y241, D395 GENBANK:XP_005606299
MER0560842 Equus przewalskii 574 132-497 D166, Y205, D359 GENBANK:XP_008536510
MER0616229 Erinaceus europaeus 481 69-405 D74, Y113, D267 GENBANK:XP_007537271
MER0661035 Esox lucius 508 62-434 D103, Y142, D296 GENBANK:XP_010887801
MER0658646 Eurypyga helias 414 1-337 D6, Y45, D199 GENBANK:XP_010150724
MER0560521 Falco cherrug 454 39-377 D46, Y85, D239 GENBANK:XP_005438643
MER0430077 Falco peregrinus 454 30-365 D46, Y85, D239 GENBANK:XP_005229573
MER0001431 Felis catus 54 28-54 missing, missing, missing PIR:A20146
MER0001431 Felis catus 54 28-54 missing, missing, missing PIR:A20146
MER0427381 Ficedula albicollis 414 13-325 D31, Y70, D199 GENBANK:XP_005037250
MER0655660 Fukomys damarensis 417 2-340 D9, Y48, D202 UNIPROT:A0A091DCZ3
MER0655660 Fukomys damarensis 417 2-340 D9, Y48, D202 UNIPROT:A0A091DCZ3
MER0557856 Galeopterus variegatus 439 1-362 D31, Y70, D224 GENBANK:XP_008569438
MER0054060 Gallus gallus 581 167-504 D173, Y212, D366 GENBANK:XP_416735
MER0654129 Gavia stellata 414 1-337 D6, Y45, D199 GENBANK:XP_009810002
MER0559559 Geospiza fortis 414 1-337 D6, Y45, D199 GENBANK:XP_005427316
MER0425695 Gorilla gorilla 439 13-350 D31, Y70, D224 GENBANK:XP_004062880
MER0429245 Gossypium raimondii 484 82-430 D101, Y171, D318 UNIPROT:A0A0D2RE53
MER0429245 Gossypium raimondii 484 82-430 D101, Y171, D318 UNIPROT:A0A0D2RE53
MER0652289 Haliaeetus leucocephalus 469 54-392 D61, Y100, D254 GENBANK:XP_010578707
MER0383794 Heterocephalus glaber 514 89-426 D107, Y146, D300 GENBANK:XP_004842523
MER0005534 Homo sapiens 518 69-441 D110, Y149, D303 UNIPROT:Q9Y5Z0
MER0005534 Homo sapiens 518 69-441 D110, Y149, D303 UNIPROT:Q9Y5Z0
MER0005534 Homo sapiens 518 69-441 D110, Y149, D303 UNIPROT:Q9Y5Z0
MER0106560 Ictidomys tridecemlineatus 414 1-337 D31, Y70, D199 GENBANK:XP_005323529
MER0425643 Jaculus jaculus 514 88-425 D106, Y145, D299 GENBANK:XP_004654549
MER0648699 Larimichthys crocea 507 61-434 D102, Y141, D296 GENBANK:XP_010731897
MER0414546 Latimeria chalumnae 382 59-372 D100, Y139, D296 GENBANK:XP_005992824
MER0553541 Lepisosteus oculatus 509 60-433 D101, Y140, D295 GENBANK:XP_006627930
MER0552739 Leptonychotes weddellii 445 32-368 D37, Y76, D230 GENBANK:XP_006740918
MER0548763 Lipotes vexillifer 464 72-379 D106, Y145, D299 GENBANK:XP_007452940
MER0548765 Lipotes vexillifer 514 72-437 D106, Y145, D299 GENBANK:XP_007452939
MER0383975 Macaca fascicularis 415 1-326 D7, Y46, D200 UNIPROT:G7P0Y8
MER0383975 Macaca fascicularis 415 1-326 D7, Y46, D200 UNIPROT:G7P0Y8
MER0496908 Macaca fascicularis 468 70-391 D110, Y149, D303 GENBANK:XP_005548712
MER0087360 Macaca mulatta 518 92-429 D110, Y149, D303 UNIPROT:I2CV83
MER0087360 Macaca mulatta 518 92-429 D110, Y149, D303 UNIPROT:I2CV83
MER0646945 Manacus vitellinus 450 34-373 D42, Y81, D235 GENBANK:XP_008929214
MER0645585 Mandrillus leucophaeus 439 1-362 D31, Y70, D224 GENBANK:XP_011839571
MER0383894 Meleagris gallopavo 420 3-331 D19, Y58, D212 GENBANK:XP_003203003
MER0643443 Mesitornis unicolor 414 1-337 D6, Y45, D199 GENBANK:XP_010181490
MER0429274 Mesocricetus auratus 514 88-425 D106, Y145, D299 GENBANK:XP_005073840
MER0425713 Microtus ochrogaster 514 88-425 D106, Y145, D299 GENBANK:XP_005370184
MER0011045 Mus musculus 514 65-437 D106, Y145, D299 GENBANK:NP_062390
MER0011045 Mus musculus 514 65-437 D106, Y145, D299 GENBANK:NP_062390
MER0011045 Mus musculus 514 65-437 D106, Y145, D299 GENBANK:NP_062390
MER0011045 Mus musculus 514 65-437 D106, Y145, D299 GENBANK:NP_062390
MER0383960 Mustela putorius 485 59-396 D77, Y116, D270 GENBANK:XP_004762352
MER0430229 Myotis brandtii 490 79-401 D82, Y121, D275 UNIPROT:S7QF78
MER0430229 Myotis brandtii 490 79-401 D82, Y121, D275 UNIPROT:S7QF78
MER0425924 Myotis davidii 415 1-326 D7, Y46, D200 UNIPROT:L5MFR9
MER0425924 Myotis davidii 415 1-326 D7, Y46, D200 UNIPROT:L5MFR9
MER0497090 Myotis lucifugus 457 46-368 D49, Y88, D242 GENBANK:XP_006104500
MER0641380 Nannospalax galili 510 62-433 D102, Y141, D295 GENBANK:XP_008849316
MER0534963 Neolamprologus brichardi 509 63-436 D104, Y143, D298 GENBANK:XP_006799898
MER0638164 Nestor notabilis 414 1-337 D6, Y45, D199 GENBANK:XP_010021505
MER0634403 Nipponia nippon 519 105-442 D111, Y150, D304 GENBANK:XP_009471852
MER0384094 Nomascus leucogenys 411 28-322 missing, Y42, D196 GENBANK:XP_003280445
MER0425656 Octodon degus 513 87-424 D105, Y144, D298 GENBANK:XP_004631849
MER0425742 Odobenus rosmarus 439 13-350 D31, Y70, D224 GENBANK:XP_004406609
MER0496700 Ophiophagus hannah 359 1-282 missing, missing, D144 UNIPROT:V8NC71
MER0496700 Ophiophagus hannah 359 1-282 missing, missing, D144 UNIPROT:V8NC71
MER0634351 Opisthocomus hoazin 454 39-377 D46, Y85, D239 GENBANK:XP_009931003
MER0425768 Orcinus orca 514 88-425 D106, Y145, D299 GENBANK:XP_004264624
MER0097813 Ornithorhynchus anatinus 553 133-476 D145, Y184, D338 GENBANK:XP_001511090
MER0528325 Orycteropus afer 518 80-441 D110, Y149, D303 GENBANK:XP_007945475
MER0605331 Oryctolagus cuniculus 421 8-344 D13, Y52, D206 GENBANK:XP_008248959
MER0111109 Oryzias latipes 501 76-436 D116, Y155, D310 GENBANK:XP_004075938
MER0427377 Ovis aries 439 13-350 D31, Y70, D224 UNIPROT:W5PK88
MER0427377 Ovis aries 439 13-350 D31, Y70, D224 UNIPROT:W5PK88
MER0383767 Pan paniscus 439 13-350 D31, Y70, D224 GENBANK:XP_003823956
MER0053469 Pan troglodytes 518 69-441 D110, Y149, D303 UNIPROT:H2R1L7
MER0053469 Pan troglodytes 518 69-441 D110, Y149, D303 UNIPROT:H2R1L7
MER0518228 Panthera tigris 501 81-424 D93, Y132, D286 GENBANK:XP_007090559
MER0497030 Pantholops hodgsonii 436 1-359 D28, Y67, D221 GENBANK:XP_005967316
MER0425764 Papio anubis 518 92-429 D110, Y149, D303 UNIPROT:A0A096NIY9
MER0425764 Papio anubis 518 92-429 D110, Y149, D303 UNIPROT:A0A096NIY9
MER0430034 Papio anubis 468 92-379 D110, Y149, D303 GENBANK:XP_003895516
MER0497104 Pelodiscus sinensis 287 1-210 missing, missing, D72 GENBANK:XP_006130579
MER0632190 Phaethon lepturus 426 13-349 D18, Y57, D211 GENBANK:XP_010291817
MER0628058 Picoides pubescens 434 19-357 D26, Y65, D219 GENBANK:XP_009904165
MER0523004 Poecilia formosa 508 63-429 D104, Y143, D298 UNIPROT:A0A087XKV7
MER0523004 Poecilia formosa 508 63-429 D104, Y143, D298 UNIPROT:A0A087XKV7
MER0513801 Poecilia reticulata 508 63-429 D104, Y143, D298 GENBANK:XP_008423517
MER0383812 Pongo abelii 578 152-489 D170, Y209, D363 GENBANK:XP_003779491
MER0425795 Pristionchus pacificus 380 39-377 D65, Y113, D264 UNIPROT:H3FEJ5
MER0496242 Pteropus alecto 367 52-290 missing, missing, D152 UNIPROT:L5KDE1
MER0496242 Pteropus alecto 367 52-290 missing, missing, D152 UNIPROT:L5KDE1
MER0496243 Pteropus alecto 240 68-140 missing, Y83, missing UNIPROT:L5K9Y4
MER0496243 Pteropus alecto 240 68-140 missing, Y83, missing UNIPROT:L5K9Y4
MER0496961 Pundamilia nyererei 509 70-429 D104, Y143, D298 GENBANK:XP_005720634
MER0443188 Python bivittatus 519 71-443 D112, Y151, D305 GENBANK:XP_007436603
MER0155677 Rattus norvegicus 514 65-437 D106, Y145, D299 GENBANK:NP_001002802
MER0155677 Rattus norvegicus 514 65-437 D106, Y145, D299 GENBANK:NP_001002802
MER0155677 Rattus norvegicus 514 65-437 D106, Y145, D299 GENBANK:NP_001002802
MER0155677 Rattus norvegicus 514 65-437 D106, Y145, D299 GENBANK:NP_001002802
MER0553390 Rhinopithecus roxellana 468 76-383 D110, Y149, D303 GENBANK:XP_010352821
MER0553505 Rhinopithecus roxellana 518 76-441 D110, Y149, D303 GENBANK:XP_010352820
MER0429282 Saimiri boliviensis 529 103-440 D121, Y160, D314 GENBANK:XP_003927785
MER0384075 Sarcophilus harrisii 414 5-326 D8, Y47, D201 GENBANK:XP_003766747
MER0543907 Serinus canaria 424 5-347 D16, Y55, D209 GENBANK:XP_009087987
MER0425689 Sorex araneus 439 13-350 D31, Y70, D224 GENBANK:XP_004602388
MER0475847 Stegastes partitus 509 63-436 D104, Y143, D298 GENBANK:XP_008274174
MER0514045 Struthio camelus 450 36-373 D42, Y81, D235 GENBANK:XP_009677875
MER0402658 synthetic construct 518 69-441 D110, Y149, D303 GENBANK:ABM86342
MER0184427 Taeniopygia guttata 441 77-364 D83, Y122, D276 GENBANK:XP_002187128
MER0596046 Tarsius syrichta 480 67-403 D72, Y111, D265 GENBANK:XP_008065277
MER0369425 Tauraco erythrolophus 414 1-337 D6, Y45, D199 GENBANK:XP_009983979
MER0155729 Tetraodon nigroviridis 472 11-391 D45, Y84, D240 UNIPROT:Q4T859
MER0155729 Tetraodon nigroviridis 472 11-391 D45, Y84, D240 UNIPROT:Q4T859
MER0425333 Tetraodon nigroviridis 374 7-185 missing, missing, D43 UNIPROT:Q4TEL9
MER0425333 Tetraodon nigroviridis 374 7-185 missing, missing, D43 UNIPROT:Q4TEL9
MER0452999 Tyto alba 414 1-337 D6, Y45, D199 GENBANK:XP_009973871
MER0201398 Ursus maritimus 436 2-359 D28, Y67, D221 GENBANK:XP_008708430
MER0497124 Vicugna pacos 443 30-366 D35, Y74, D228 GENBANK:XP_006205113
MER0035747 Xenopus laevis 500 53-425 D94, Y133, D287 UNIPROT:Q7T0Y2
MER0035747 Xenopus laevis 500 53-425 D94, Y133, D287 UNIPROT:Q7T0Y2
MER0087707 Xenopus tropicalis 499 76-412 D93, Y132, D286 UNIPROT:B4F734
MER0087707 Xenopus tropicalis 499 76-412 D93, Y132, D286 UNIPROT:B4F734
MER0496977 Xiphophorus maculatus 459 15-385 D56, Y95, D250 GENBANK:XP_005805990
MER0496897 Zonotrichia albicollis 398 1-309 D15, Y54, D183 GENBANK:XP_005489028