Activity |
Catalytic type | Cysteine |
Peplist | Included in the Peplist with identifier PL00060 |
NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.15
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Enzymology | BRENDA database |
Proteolytic events | CutDB database (47 cleavages) |
Activity status | human: active (Kirschke, 2004) mouse: active (Mason et al., 1989)
|
Physiology | Endopeptidase activity in lysosomal proteolysis, and probably also contributes to the generation of anigenic peptides for the MHC II system. In addition, it is reported that cathepsin L synthesised without a signal peptide localises to the nucleus, and functions in the regulation of cell cycle progression through proteolytic processing of the CDP/Cux transcription factor (Goulet et al., 2004). |
Knockout | The gene was inactivated by gene targeting in mouse embryonic stem cells (Roth et al., 2000). The deficient mice develop periodic hair loss and epidermal hyperplasia, acanthosis, and hyperkeratosis. Cathepsin L deficiency was shown to be a molecular defect of the previously-known furless mouse. Combined deficiency of cathepsins B and L in mice is lethal during the second to fourth week, and associated with a degree of brain atrophy not previously seen in mice (Felbor et al., 2002). Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis (Wright et al., 2003). |
Pathways |
KEGG | Antigen processing and presentation |
|
KEGG | Lysosome |
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KEGG | Phagosome |
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KEGG | Proteoglycans in cancer |
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KEGG | Rheumatoid arthritis |
Other databases
| WIKIPEDIA | http://en.wikipedia.org/wiki/Cathepsin_L1 |
Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
Cleavage pattern | -/-/lv/--/-/-/- (based on 6703 cleavages) |