Literature for peptidase C01.032: cathepsin L

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Bestle,D., Bittel,L., Werner,A.D., Kamper,L., Dolnik,O., Krahling,V., Steinmetzer,T. and Bottcher-Friebertshauser,E. \<br\>Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage\<br\>Virus Res (2024) 347, 199430. PubMed  Europe PubMed DOI  K
  2. Chiang,Y.R., Lin,H.T., Chang,C.W., Lin,S.M. and Lin,J.H. \<br\>Dynamic expression of cathepsin L in the black soldier fly (Hermetia illucens) gut during Escherichia coli challenge\<br\>PLoS ONE (2024) 19, e0298338. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Ciaglia,T., Vestuto,V., Di Sarno,V., Musella,S., Smaldone,G., Di Matteo,F., Napolitano,V., Miranda,M.R., Pepe,G., Basilicata,M.G., Novi,S., Capolupo,I., Bifulco,G., Campiglia,P., Gomez-Monterrey,I., Snoeck,R., Andrei,G., Manfra,M., Ostacolo,C., Lauro,G. and Bertamino,A. \<br\>Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization\<br\>Eur J Med Chem (2024) 266, 116128. PubMed  Europe PubMed DOI  I
  4. Deng,W., Hu,X., Tian,X., Zhang,Y., Shang,W., Zhang,L. and Shang,L. \<br\>Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L\<br\>J Med Chem (2024) PubMed  Europe PubMed DOI  I
  5. Falke,S., Lieske,J., Herrmann,A., Loboda,J., Karnicar,K., Gunther,S., Reinke,P.Y.A., Ewert,W., Usenik,A., Lindic,N., Sekirnik,A., Dretnik,K., Tsuge,H., Turk,V., Chapman,H.N., Hinrichs,W., Ebert,G., Turk,D. and Meents,A. \<br\>Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors\<br\>J Med Chem (2024) PubMed  Europe PubMed DOI  I
  6. Kim,M.J., Kim,S., Reinheckel,T. and Krainc,D. \<br\>Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase\<br\>JCI Insight (2024) 9, PubMed  Europe PubMed DOI  PMC  EPMC
  7. Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X. \<br\>Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19\<br\>Med (2024) 5, 169-171. PubMed  Europe PubMed DOI  I
  8. Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X. \<br\>Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19\<br\>Med (2024) 5, 42-61. PubMed  Europe PubMed DOI  I
  9. Matouskova,Z., Orsaghova,K., Srb,P., Pytelkova,J., Kukacka,Z., Busa,M., Hajdusek,O., Sima,R., Fabry,M., Novak,P., Horn,M., Kopacek,P. and Mares,M. \<br\>An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans\<br\>Int J Mol Sci (2024) 25, PubMed  Europe PubMed DOI  PMC  EPMC
  10. Matsuki,A., Watanabe,Y., Hashimoto,S., Hoshino,A. and Matoba,S. \<br\>Cathepsin L prevents the accumulation of alpha-synuclein fibrils in the cell\<br\>Genes Cells (2024) 29, 328-336. PubMed  Europe PubMed DOI
  11. Oliveira,B.R., Nehlmeier,I., Kempf,A.M., Venugopalan,V., Rehders,M., Ceniza,M.E.P., Cavalcanti,P.A.T.P., Hoffmann,M., Pohlmann,S. and Brix,K. \<br\>Cytoskeletal beta-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y\<br\>Biochimie (2024) PubMed  Europe PubMed DOI
  12. Peng,Z., Luo,X.Y., Li,X., Li,Y., Wu,Y., Tian,Y., Pan,B., Petrovic,A., Kosanovic,D., Schermuly,R.T., Ruppert,C., Gunther,A., Zhang,Z., Qiu,C., Li,Y., Pu,J., Li,X. and Chen,A.F. \<br\>Cathepsin L Promotes Pulmonary Hypertension via BMPR2/GSDME-Mediated Pyroptosis\<br\>Hypertension (2024) PubMed  Europe PubMed DOI
  13. Previti,S., Ettari,R., Calcaterra,E., Roggia,M., Natale,B., Weldert,A.C., Muller-Ruttloff,C., Salisch,F., Irto,A., Cigala,R.M., Ziebuhr,J., Schirmeister,T., Cosconati,S. and Zappala,M. \<br\>Identification of Dual Inhibitors Targeting Main Protease (M(pro)) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents\<br\>ACS Med Chem Lett (2024) 15, 602-609. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Wu,Y., Jiang,D., Liu,Q., Yan,S., Liu,X., Wu,T., Sun,W. and Li,G. \<br\>Cathepsin L induces cellular senescence by upregulating CUX1 and p16(INK4a)\<br\>Aging (Albany NY) (2024) 16, PubMed  Europe PubMed DOI
  15. Xie,X., Lan,Q., Zhao,J., Zhang,S., Liu,L., Zhang,Y., Xu,W., Shao,M., Peng,J., Xia,S., Zhu,Y., Zhang,K., Zhang,X., Zhang,R., Li,J., Dai,W., Ge,Z., Hu,S., Yu,C., Wang,J., Ma,D., Zheng,M., Yang,H., Xiao,G., Rao,Z., Lu,L., Zhang,L., Bai,F., Zhao,Y., Jiang,S. and Liu,H. \<br\>Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1\<br\>Signal Transduct Target Ther (2024) 9, 54. PubMed  Europe PubMed DOI  PMC  EPMC  I
  16. Xu,B., Anderson,B.M., Mountford,S.J., Thompson,P.E., Mintern,J.D. and Edgington-Mitchell,L.E. \<br\>Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate\<br\>Biol Chem (2024) PubMed  Europe PubMed DOI
  17. Yang,H., Zhou,J.N., Zhang,X.M., Ling,D.D., Sun,Y.B., Li,C.Y., Zhou,Q.Q., Shi,G.N., Wang,S.H., Lin,X.S., Fan,T., Wang,H.Y., Zeng,Q., Jia,Y.L., Xi,J.F., Jin,Y.G., Pei,X.T. and Yue,W. \<br\>Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS-CoV-2 Pseudovirus Entry into Lung ACE2(+) Cells\<br\>Adv Mater (2024) e2310306. PubMed  Europe PubMed DOI
  18. Zhang,Z., Wang,J., Shi,Y., Wang,B. and Wang,D. \<br\>Cathepsin L promotes oesophageal squamous cell carcinoma development and may be associated with tumour-associated macrophages\<br\>Heliyon (2024) 10, e29273. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Zhou,W., You,B., Zhao,X., Si,S., Li,Y. and Zhang,J. \<br\>Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors\<br\>SLAS Discov (2024) 29, 100153. PubMed  Europe PubMed DOI  I
  20. Zhou,W., You,B., Zheng,Y., Si,S., Li,Y. and Zhang,J. \<br\>Expression, purification, and biological activity evaluation of cathepsin L in mammalian cells\<br\>Biosci Biotechnol Biochem (2024) 88, 405-411. PubMed  Europe PubMed DOI
  21. 2023
  22. Abdelaziz,R.F., Hussein,A.M., Kotob,M.H., Weiss,C., Chelminski,K., Stojanovic,T., Studenik,C.R. and Aufy,M. \<br\>Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells\<br\>Int J Mol Sci (2023) 24, PubMed  Europe PubMed DOI  PMC  EPMC
  23. Doijen,J., Temmerman,K., Van den Eynde,C., Diels,A., Van den Broeck,N., Van Gool,M., Heo,I., Jaensch,S., Zwaagstra,M., Diosa Toro,M., Chiu,W., De Jonghe,S., Leyssen,P., Bojkova,D., Ciesek,S., Cinatl,J., Verschueren,L., Buyck,C., van Kuppeveld,F., Neyts,J., Van Loock,M. and Van Damme,E. \<br\>Identification of Z-Tyr-Ala-CHN(2), a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2\<br\>Microorganisms (2023) 11, PubMed  Europe PubMed DOI  PMC  EPMC  I
  24. Ezz,M.A., Takahashi,M., Rivera,R.M. and Balboula,A.Z. \<br\>Cathepsin L regulates oocyte meiosis and preimplantation embryo development\<br\>Cell Prolif (2023) e13526. PubMed  Europe PubMed DOI
  25. Fernandez-de-la-Pradilla,A., Royo,S., Schirmeister,T., Barthels,F., Swiderek,K., Gonzalez,F.V. and Moliner,V. \<br\>Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L\<br\>ACS Catal (2023) 13, 13354-13368. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Grozdanic,M., Sobotic,B., Biasizzo,M., Sever,T., Vidmar,R., Vizovisek,M., Turk,B. and Fonovic,M. \<br\>Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer\<br\>Biol Chem (2023) PubMed  Europe PubMed DOI
  27. Huang,H., Zhang,Y., Xu,X., Liu,Y., Zhao,J., Ma,L., Lei,J., Ge,W., Li,N., Ma,E., Li,Y. and Yuan,L. \<br\>Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells\<br\>Bioorg Med Chem Lett (2023) 80, 129087. PubMed  Europe PubMed DOI  I
  28. Kondo,Y., Rajapakse,S. and Ogiwara,K. \<br\>Involvement of cathepsin L in the degradation and degeneration of postovulatory follicle of the medaka ovarydagger\<br\>Biol Reprod (2023) 109, 904-917. PubMed  Europe PubMed DOI
  29. Li,Y., Wang,K., Sun,H., Wu,S., Wang,H., Shi,Y., Li,X., Yan,H., Yang,G., Wu,M., Li,Y., Ding,X., Si,S., Jiang,J., Du,Y., Li,Y. and Hong,B. \<br\>Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2\<br\>Antiviral Res (2023) 214, 105606. PubMed  Europe PubMed DOI  PMC  EPMC  I
  30. Tang,T.T., Li,S.M., Pan,B.W., Xiao,J.W., Pang,Y.X., Xie,S.X., Zhou,Y., Yang,J. and Wei,Y. \<br\>Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure-Activity Relationships\<br\>Molecules (2023) 28, PubMed  Europe PubMed DOI  PMC  EPMC  I
  31. Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D. \<br\>Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins\<br\>Commun Biol (2023) 6, 450. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Wang,C., Ye,X., Ding,C., Zhou,M., Li,W., Wang,Y., You,Q., Zong,S., Peng,Q., Duanmu,D., Chen,H., Sun,B. and Qiao,J. \<br\>Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry\<br\>J Agric Food Chem (2023) 71, 5535-5546. PubMed  Europe PubMed DOI  PMC  EPMC  I
  33. 2022
  34. Denamur,S., Chazeirat,T., Maszota-Zieleniak,M., Vives,R.R., Saidi,A., Zhang,F., Linhardt,R.J., Labarthe,F., Samsonov,S.A., Lalmanach,G. and Lecaille,F. \<br\>Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: Putative consequences in mucopolysaccharidosis\<br\>Carbohydr Polym (2022) 293, 119734. PubMed  Europe PubMed DOI
  35. Gaikwad,P. and Kemp,M.G. \<br\>Cathepsin L inhibition prevents the cleavage of multiple nuclear proteins upon lysis of quiescent human cells\<br\>MicroPubl Biol (2022) 2022, PubMed  Europe PubMed DOI  PMC  EPMC
  36. Islam,M.I., Nagakannan,P., Shcholok,T., Contu,F., Mai,S., Albensi,B.C., Del Bigio,M.R., Wang,J.F., Sharoar,M.G., Yan,R., Park,I.S. and Eftekharpour,E. \<br\>Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer's disease\<br\>Aging Cell (2022) 21, e13531. PubMed  Europe PubMed DOI
  37. Kladnik,J., Dolinar,A., Kljun,J., Perea,D., Grau-Exposito,J., Genesca,M., Novinec,M., Buzon,M.J. and Turel,I. \<br\>Zinc pyrithione is a potent inhibitor of PL(Pro) and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication\<br\>J Enzyme Inhib Med Chem (2022) 37, 2158-2168. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Kwon,C.W., Yeo,S. and Chang,P.S. \<br\>Characterization and molecular docking study of cathepsin L inhibitory peptides (SnuCalCpIs) from Calotropis procera R. Br\<br\>Sci Rep (2022) 12, 5825. PubMed  Europe PubMed DOI  PMC  EPMC  I
  39. Li,C., Liu,Z., Chen,M., Zhang,L., Shi,R. and Zhong,H. \<br\>Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence\<br\>Biology (Basel) (2022) 12, PubMed  Europe PubMed DOI  PMC  EPMC
  40. Meewan,I., Kattoula,J., Kattoula,J.Y., Skinner,D., Fajtova,P., Giardini,M.A., Woodworth,B., McKerrow,J.H., Lage de Siqueira-Neto,J., O'Donoghue,A.J. and Abagyan,R. \<br\>Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L\<br\>Pharmaceuticals (Basel) (2022) 15, PubMed  Europe PubMed DOI  PMC  EPMC  I
  41. Mondal,S., Chen,Y., Lockbaum,G.J., Sen,S., Chaudhuri,S., Reyes,A.C., Lee,J.M., Kaur,A.N., Sultana,N., Cameron,M.D., Shaffer,S.A., Schiffer,C.A., Fitzgerald,K.A. and Thompson,P.R. \<br\>Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2\<br\>J Am Chem Soc (2022) 144, 21035-21045. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  42. Mouawad,J.E., Sharma,S., Renaud,L., Pilewski,J.M., Nadig,S.N. and Feghali-Bostwick,C. \<br\>Reduced Cathepsin L Expression and Secretion into the Extracellular Milieu Contribute to Lung Fibrosis in Systemic Sclerosis\<br\>Rheumatology (Oxford) (2022) PubMed  Europe PubMed DOI
  43. Novinec,M., Bembic,P., Jankovic,M., Kisilak,M., Kljun,J. and Turel,I. \<br\>Kinetic Characterization of Cerium and Gallium Ions as Inhibitors of Cysteine Cathepsins L, K, and S\<br\>Int J Mol Sci (2022) 23, PubMed  Europe PubMed DOI  PMC  EPMC
  44. Wang,S., Luke,C.J., Pak,S.C., Shi,V., Chen,L., Moore,J., Andress,A.P., Jayachandran,K., Zhang,J., Huang,Y., Platik,M., Apicelli,A.A., Schwarz,J.K., Grigsby,P.W., Silverman,G.A. and Markovina,S. \<br\>SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation\<br\>Commun Biol (2022) 5, 46. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Wang,X., Liu,D., Liu,F., Xiao,L., Ni,H., Qi,X., Xing,K., Cai,D., Sheng,X. and Guo,Y. \<br\>Cathepsin L involved in the freezing resistance of murine normal hatching embryos and dormant embryos\<br\>Reprod Biol (2022) 22, 100612. PubMed  Europe PubMed DOI
  46. Yang,W.L., Li,Q., Sun,J., Huat Tan,S., Tang,Y.H., Zhao,M.M., Li,Y.Y., Cao,X., Zhao,J.C. and Yang,J.K. \<br\>Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy\<br\>Comput Struct Biotechnol J (2022) 20, 2442-2454. PubMed  Europe PubMed DOI  PMC  EPMC  I
  47. Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V. \<br\>Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases\<br\>ACS Chem Neurosci (2022) 13, 245-256. PubMed  Europe PubMed DOI
  48. Yu,F., Pan,T., Huang,F., Ying,R., Liu,J., Fan,H., Zhang,J., Liu,W., Lin,Y., Yuan,Y., Yang,T., Li,R., Zhang,X., Lv,X., Chen,Q., Liang,A., Zou,F., Liu,B., Hu,F., Tang,X., Li,L., Deng,K., He,X., Zhang,H., Zhang,Y. and Ma,X. \<br\>Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L\<br\>Front Microbiol (2022) 13, 884034. PubMed  Europe PubMed DOI  PMC  EPMC  I
  49. Zhao,M.M., Zhu,Y., Zhang,L., Zhong,G., Tai,L., Liu,S., Yin,G., Lu,J., He,Q., Li,M.J., Zhao,R.X., Wang,H., Huang,W., Fan,C., Shuai,L., Wen,Z., Wang,C., He,X., Chen,Q., Liu,B., Xiong,X., Bu,Z., Wang,Y., Sun,F. and Yang,J.K. \<br\>Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies\<br\>Cell Discov (2022) 8, 53. PubMed  Europe PubMed DOI  PMC  EPMC
  50. 2021
  51. Berdowska,I. and Matusiewicz,M. \<br\>Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis - with impact on gastrointestinal tract\<br\>World J Gastroenterol (2021) 27, 6590-6600. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Bollavaram,K., Leeman,T.H., Lee,M.W., Kulkarni,A., Upshaw,S.G., Yang,J., Song,H. and Platt,M.O. \<br\>Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V\<br\>Protein Sci (2021) PubMed  Europe PubMed DOI
  53. Breidenbach,J., Lemke,C., Pillaiyar,T., Schakel,L., Al Hamwi,G., Diett,M., Gedschold,R., Geiger,N., Lopez,V., Mirza,S., Namasivayam,V., Schiedel,A.C., Sylvester,K., Thimm,D., Vielmuth,C., Phuong Vu,L., Zyulina,M., Bodem,J., Gutschow,M. and Muller,C.E. \<br\>Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors\<br\>Angew Chem Int Ed Engl (2021) PubMed  Europe PubMed DOI  I
  54. Caval,T., Hecht,E.S., Tang,W., Uy-Gomez,M., Nichols,A., Kil,Y.J., Sandoval,W., Bern,M. and Heck,A.J.R. \<br\>The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies\<br\>FEBS J (2021) PubMed  Europe PubMed DOI
  55. Choudhury,D. and Biswas,S. \<br\>Structure-guided protein engineering of human cathepsin L for efficient collagenolytic activity\<br\>Protein Eng Des Sel (2021) 34, PubMed  Europe PubMed DOI
  56. Dominguez-Hernandez,E. and Ertbjerg,P. \<br\>Effect of LTLT heat treatment on cathepsin B and L activities and denaturation of myofibrillar proteins of pork\<br\>Meat Sci (2021) 175, 108454. PubMed  Europe PubMed DOI
  57. Eckl,K.M., Gruber,R., Brennan,L., Marriott,A., Plank,R., Moosbrugger-Martinz,V., Blunder,S., Schossig,A., Altmuller,J., Thiele,H., Nurnberg,P., Zschocke,J., Hennies,H.C. and Schmuth,M. \<br\>Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V\<br\>Front Genet (2021) 12, 689940. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J. \<br\>Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses\<br\>ACS Infect Dis (2021) 7, 586-597. PubMed  Europe PubMed DOI  PMC  EPMC  I
  59. Huang,M., Chen,S.P., Dai,Y.Y., Yang,Y., Jiang,W., Wang,F., Zhang,J.X. and Zhu,Q.X. \<br\>[Cathepsin L mediates glomerular endothelial cell injury by cleavaging complement C3 in trichloroethylene-sensitized mice]\<br\>Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2021) 39, 5-11. PubMed  Europe PubMed DOI
  60. IstIflI,E.S., SihoGlu Tepe,A., Netz,P.A., SarikUrkcU,C., Kilic,I.H. and Tepe,B. \<br\>Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols\<br\>Turk J Biol (2021) 45, 484-502. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Jackson,C.B., Farzan,M., Chen,B. and Choe,H. \<br\>Mechanisms of SARS-CoV-2 entry into cells\<br\>Nat Rev Mol Cell Biol (2021) PubMed  Europe PubMed DOI  PMC  EPMC  V
  62. Kim,J.Y., Lee,E.J., Ahn,Y., Park,S., Bae,Y.J., Kim,T.G. and Oh,S.H. \<br\>Cathepsin L, a Target of Hypoxia-Inducible Factor-1-alpha, Is Involved in Melanosome Degradation in Melanocytes\<br\>Int J Mol Sci (2021) 22, PubMed  Europe PubMed DOI  PMC  EPMC
  63. Li,Y., Ai,X., Zou,C., Liu,Y., Ma,L., Men,J., Liu,D., Sheng,L., Ruan,X., Liu,H., Li,W., Ma,E. and Yuan,L. \<br\>Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells\<br\>Bioorg Chem (2021) 115, 105256. PubMed  Europe PubMed DOI  I
  64. Mellott,D.M., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D.H., Hsu,J., Zhu,J., Taylor,Z.W., Kocurek,K.I., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Yoon,M.C., Beck,S., Carlin,A.F., Clark,A.E., Beretta,L., Maneval,D., Hook,V., Frueh,F., Hurst,B.L., Wang,H., Raushel,F.M., O'Donoghue,A.J., de Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H. \<br\>A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells\<br\>ACS Chem Biol (2021) 16, 642-650. PubMed  Europe PubMed DOI  PMC  EPMC  I
  65. Munikishore,R., Wang,L.L., Zhang,S., Zhao,Q.S. and Zuo,Z. \<br\>An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94\<br\>Bioorg Chem (2021) 116, 105317. PubMed  Europe PubMed DOI  I
  66. Pathak,M., Vani,V. and Seshagiri,P.B. \<br\>Expression and function of interleukin-1beta is required for hamster blastocyst hatching: Involvement of hatching-associated cathepsin proteases\<br\>Mol Reprod Dev (2021) 88, 274-286. PubMed  Europe PubMed DOI
  67. Phan,H.A.T., Giannakoulias,S.G., Barrett,T.M., Liu,C. and Petersson,E.J. \<br\>Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L\<br\>Chem Sci (2021) 12, 10825-10835. PubMed  Europe PubMed DOI  PMC  EPMC  I
  68. Reed,B., Crawford,F., Hill,R.C., Jin,N., White,J., Krovi,S.H., Marrack,P., Hansen,K. and Kappler,J.W. \<br\>Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation\<br\>J Exp Med (2021) 218, PubMed  Europe PubMed DOI
  69. Shibamura-Fujiogi,M., Yuki,K. and Hou,L. \<br\>Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis\<br\>Int Immunopharmacol (2021) 93, 107425. PubMed  Europe PubMed DOI
  70. Steuten,K., Kim,H., Widen,J.C., Babin,B.M., Onguka,O., Lovell,S., Bolgi,O., Cerikan,B., Neufeldt,C.J., Cortese,M., Muir,R.K., Bennett,J.M., Geiss-Friedlander,R., Peters,C., Bartenschlager,R. and Bogyo,M. \<br\>Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19\<br\>ACS Infect Dis (2021) PubMed  Europe PubMed DOI  PMC  EPMC
  71. Yang,J., Chen,T. and Zhou,Y. \<br\>Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes\<br\>Hereditas (2021) 158, 4. PubMed  Europe PubMed DOI  PMC  EPMC
  72. Zhao,M.M., Yang,W.L., Yang,F.Y., Zhang,L., Huang,W.J., Hou,W., Fan,C.F., Jin,R.H., Feng,Y.M., Wang,Y.C. and Yang,J.K. \<br\>Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development\<br\>Signal Transduct Target Ther (2021) 6, 134. PubMed  Europe PubMed DOI  PMC  EPMC  K
  73. 2020
  74. Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R. \<br\>Potential protease inhibitors and their combinations to block SARS-CoV-2\<br\>J Biomol Struct Dyn (2020) 1-15. PubMed  Europe PubMed DOI  PMC  EPMC  I
  75. Almasi,F. and Mohammadipanah,F. \<br\>Hypothetical targets and plausible drugs of coronavirus infection caused by SARS-CoV-2\<br\>Transbound Emerg Dis (2020) PubMed  Europe PubMed DOI  PMC  EPMC
  76. Arafet,K., Gonzalez,F.V. and Moliner,V. \<br\>Quantum mechanics/molecular mechanics studies of the mechanism of cysteine proteases inhibition by dipeptidyl nitroalkenes\<br\>Chemistry (2020) 26, 2002-2012. PubMed  Europe PubMed DOI  I
  77. Ashhurst,A.S., Tang,A.H., Fajtova,P., Yoon,M., Aggarwal,A., Stoye,A., Larance,M., Beretta,L., Drelich,A., Skinner,D., Li,L., Meek,T.D., McKerrow,J.H., Hook,V., Tseng,C.K., Turville,S., Gerwick,W.H., O'Donoghue,A.J. and Payne,R.J. \<br\>Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L\<br\>bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  78. Barnett,B.P., Wahlin,K., Krawczyk,M., Spencer,D., Welsbie,D., Afshari,N. and Chao,D. \<br\>Potential of Ocular Transmission of SARS-CoV-2: A Review\<br\>Vision (Basel) (2020) 4, PubMed  Europe PubMed DOI  V
  79. Blaess,M., Kaiser,L., Sauer,M., Csuk,R. and Deigner,H.P. \<br\>COVID-19/SARS-CoV-2 Infection: Lysosomes and Lysosomotropism Implicate New Treatment Strategies and Personal Risks\<br\>Int J Mol Sci (2020) 21, PubMed  Europe PubMed DOI  PMC  EPMC
  80. Braz,H.L.B., Silveira,J.A.M., Marinho,A.D., de Moraes,M.E.A., Moraes Filho,M.O., Monteiro,H.S.A. and Jorge,R.J.B. \<br\>In silico study of azithromycin, chloroquine and hydroxychloroquine and their potential mechanisms of action against SARS-CoV-2 infection\<br\>Int J Antimicrob Agents (2020) 106119. PubMed  Europe PubMed DOI  PMC  EPMC
  81. Brings,S., Fleming,T., Herzig,S., Nawroth,P.P. and Kopf,S. \<br\>Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study\<br\>J Diabetes Complications (2020) 107648. PubMed  Europe PubMed DOI
  82. Chen,J., Zhang,L., Yang,N., Cao,M., Tian,M., Fu,Q., Su,B. and Li,C. \<br\>Characterization of the immune roles of cathepsin L in turbot (Scophthalmus maximus L.) mucosal immunity\<br\>Fish Shellfish Immunol (2020) 97, 322-335. PubMed  Europe PubMed DOI
  83. Cianni,L., Rocho,F.D.R., Rosini,F., Bonatto,V., Ribeiro,J.F.R., Lameira,J., Leitao,A., Shamim,A. and Montanari,C.A. \<br\>Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases\<br\>Bioorg Chem (2020) 101, 104039. PubMed  Europe PubMed DOI  I
  84. Dana,D. and Pathak,S.K. \<br\>A review of small molecule inhibitors and functional probes of human cathepsin L\<br\>Molecules (2020) 25, PubMed  Europe PubMed DOI  V  I
  85. Eapen,M.S., Lu,W., Hackett,T.L., Singhera,G.K., Thompson,I.E., McAlinden,K.D., Hardikar,A., Weber,H.C., Haug,G., Wark,P.A.B., Chia,C. and Sohal,S.S. \<br\>Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections\<br\>Am J Physiol Lung Cell Mol Physiol (2020) PubMed  Europe PubMed DOI
  86. Filippova,I.Y., Dvoryakova,E.A., Sokolenko,N.I., Simonyan,T.R., Tereshchenkova,V.F., Zhiganov,N.I., Dunaevsky,Y.E., Belozersky,M.A., Oppert,B. and Elpidina,E.N. \<br\>New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family\<br\>Front Mol Biosci (2020) 7, 578758. PubMed  Europe PubMed DOI  PMC  EPMC
  87. Fonseca Lameiro,R.D., Shamim,A., Rosini,F., Cendron,R., Jatai Batista,P.H. and Montanari,C.A. \<br\>Synthesis, biochemical evaluation and molecular modeling studies of nonpeptidic nitrile-based fluorinated compounds\<br\>Future Med Chem (2020) PubMed  Europe PubMed DOI
  88. Gomes,C.P., Fernandes,D.E., Casimiro,F., da Mata,G.F., Passos,M.T., Varela,P., Mastroianni-Kirsztajn,G. and Pesquero,J.B. \<br\>Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics\<br\>Front Cell Infect Microbiol (2020) 10, 589505. PubMed  Europe PubMed DOI  PMC  EPMC
  89. Jaimes,J., Millet,J. and Whittaker,G. \<br\>Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site\<br\>SSRN (2020) 3581359. PubMed  Europe PubMed DOI  PMC  EPMC
  90. Kerslake,R., Hall,M., Randeva,H.S., Spandidos,D.A., Chatha,K., Kyrou,I. and Karteris,E. \<br\>Coexpression of peripheral olfactory receptors with SARSCoV2 infection mediators: Potential implications beyond loss of smell as a COVID19 symptom\<br\>Int J Mol Med (2020) 46, 949-956. PubMed  Europe PubMed DOI  PMC  EPMC
  91. Kodama,R.T., Kuniyoshi,A.K., da Silva,C.C.F., Cajado-Carvalho,D., Duzzi,B., Mariano,D.C., Pimenta,D.C., Borges,R., da Silva,W.D. and Portaro,F.C.V. \<br\>A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases\<br\>J Venom Anim Toxins Incl Trop Dis (2020) 26, e20200037. PubMed  Europe PubMed DOI  PMC  EPMC
  92. Li,H., Xie,L., Chen,L., Zhang,L., Han,Y., Yan,Z. and Guo,X. \<br\>Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer\<br\>Aging (Albany NY) (2020) 12, 22370-22389. PubMed  Europe PubMed DOI
  93. Liu,H., Gai,S., Wang,X., Zeng,J., Sun,C., Zhao,Y. and Zheng,Z. \<br\>Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart\<br\>Cardiovasc Res (2020) 116, 1733-1741. PubMed  Europe PubMed DOI
  94. Madadlou,A. \<br\>Food proteins are a potential resource for mining cathepsin L inhibitory drugs to combat SARS-CoV-2\<br\>Eur J Pharmacol (2020) 885, 173499. PubMed  Europe PubMed DOI  PMC  EPMC
  95. Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H. \<br\>A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells\<br\>bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  96. Mishra,C.B., Pandey,P., Sharma,R.D., Malik,M.Z., Mongre,R.K., Lynn,A.M., Prasad,R., Jeon,R. and Prakash,A. \<br\>Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach\<br\>Brief Bioinform (2020) PubMed  Europe PubMed DOI  PMC  EPMC
  97. Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S. and Singh,S. \<br\>Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases\<br\>Pharmaceuticals (Basel) (2020) 14, PubMed  Europe PubMed DOI  PMC  EPMC
  98. Niu,R., Wang,J., Geng,C., Li,Y., Dong,L., Liu,L., Chang,Y., Shen,J., Nie,Z., Zhang,Y. and Hu,B. \<br\>Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy\<br\>Aging (Albany NY) (2020) 12, PubMed  Europe PubMed DOI
  99. Padmanabhan,P., Desikan,R. and Dixit,N.M. \<br\>Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection\<br\>PLoS Comput Biol (2020) 16, e1008461. PubMed  Europe PubMed DOI
  100. Parigiani,M.A., Ketscher,A., Timme,S., Bronsert,P., Schlimpert,M., Kammerer,B., Jacquel,A., Chaintreuil,P. and Reinheckel,T. \<br\>Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression\<br\>Cancers (Basel) (2020) 12, PubMed  Europe PubMed DOI  K
  101. Pritsch,I.C., Tikhonova,I.G., Jewhurst,H.L., Drysdale,O., Cwiklinski,K., Molento,M.B., Dalton,J.P. and Verissimo,C.M. \<br\>Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition\<br\>BMC Mol Cell Biol (2020) 21, 90. PubMed  Europe PubMed DOI  PMC  EPMC
  102. Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J. \<br\>Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity\<br\>Cancers (Basel) (2020) 12, PubMed  Europe PubMed DOI  PMC  EPMC
  103. Ribeiro,J.F.R., Cianni,L., Li,C., Warwick,T.G., De Vita,D., Rosini,F., Dos Reis Rocho,F., Martins,F.C.P., Kenny,P.W., Lameira,J., Leitao,A., Emsley,J. and Montanari,C.A. \<br\>Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor\<br\>Bioorg Med Chem (2020) 28, 115743. PubMed  Europe PubMed DOI  I
  104. Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J. \<br\>Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L\<br\>bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC  I
  105. Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J. \<br\>Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L\<br\>Sci Adv (2020) PubMed  Europe PubMed DOI  I
  106. Schleyer,K.A., Fetrow,B., Fatland,P.Z., Liu,J., Chaaban,M., Ma,B. and Cui,L. \<br\>Intrinsically quenched fluorogenic probe provides selective and rapid detection of cathepsin L activity\<br\>ChemMedChem (2020) PubMed  Europe PubMed DOI
  107. Seth,S., Batra,J. and Srinivasan,S. \<br\>COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response\<br\>Front Mol Biosci (2020) 7, 215. PubMed  Europe PubMed DOI  PMC  EPMC  V
  108. Seyedpour,S., Khodaei,B., Loghman,A.H., Seyedpour,N., Kisomi,M.F., Balibegloo,M., Nezamabadi,S.S., Gholami,B., Saghazadeh,A. and Rezaei,N. \<br\>Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms: A systematic review of in vitro and in vivo studies\<br\>J Cell Physiol (2020) PubMed  Europe PubMed DOI
  109. Shi,X. and Zhang,Y. \<br\>A humanized antibody inhibitor for cathepsin L\<br\>Protein Sci (2020) PubMed  Europe PubMed DOI
  110. Smith,D., Cwiklinski,K., Jewhurst,H., Tikhonova,I.G. and Dalton,J.P. \<br\>An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica\<br\>Sci Rep (2020) 10, 20657. PubMed  Europe PubMed DOI  PMC  EPMC
  111. Toman,N.P., Kamenik,A.S., Santos,L.H., Hofer,F., Liedl,K.R. and Ferreira,R.S. \<br\>Profiling selectivity of chagasin mutants towards cysteine proteases cruzain or cathepsin L through molecular dynamics simulations\<br\>J Biomol Struct Dyn (2020) 1-13. PubMed  Europe PubMed DOI
  112. Ulcakar,L. and Novinec,M. \<br\>Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives\<br\>Biomolecules (2020) 11, PubMed  Europe PubMed DOI  PMC  EPMC
  113. Valois,M.V., de Oliveira,C., Lapa,A.J., Souccar,C. and Oliva,M.L.V. \<br\>Bauhinia Protease Inhibitors Attenuate Gastric Ulcer by Blocking Neutrophil Enzymes\<br\>Planta Med (2020) PubMed  Europe PubMed DOI
  114. Vargas-Alarcon,G., Posadas-Sanchez,R. and Ramirez-Bello,J. \<br\>Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies\<br\>Life Sci (2020) 260, 118313. PubMed  Europe PubMed DOI  PMC  EPMC
  115. Vivek-Ananth,R.P., Rana,A., Rajan,N., Biswal,H.S. and Samal,A. \<br\>In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection\<br\>Molecules (2020) 25, PubMed  Europe PubMed DOI
  116. Wang,Z., Xiang,Z., Zhu,T., Chen,J., Zhong,M.Z., Huang,J., Wang,K.S., Li,L., Sun,L.Q. and Zhou,W.B. \<br\>Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer\<br\>Oncol Lett (2020) 19, 167-176. PubMed  Europe PubMed DOI  PMC  EPMC
  117. Wei,J., Alfajaro,M.M., Hanna,R.E., DeWeirdt,P.C., Strine,M.S., Lu-Culligan,W.J., Zhang,S.M., Graziano,V.R., Schmitz,C.O., Chen,J.S., Mankowski,M.C., Filler,R.B., Gasque,V., de Miguel,F., Chen,H., Oguntuyo,K., Abriola,L., Surovtseva,Y.V., Orchard,R.C., Lee,B., Lindenbach,B., Politi,K., van Dijk,D., Simon,M.D., Yan,Q., Doench,J.G. and Wilen,C.B. \<br\>Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection\<br\>bioRxiv (2020) PubMed  Europe PubMed DOI  PMC  EPMC
  118. Yu,C., Wan,Y., Xu,W., Jin,X., Zhang,S., Xin,M., Jiang,H. and Cheng,X. \<br\>Increased Circulating Cathepsin L in Patients with Coronary Artery Disease\<br\>Int Heart J (2020) PubMed  Europe PubMed DOI
  119. 2019
  120. Boudreau,P.D., Miller,B.W., McCall,L.I., Almaliti,J., Reher,R., Hirata,K., Le,T., Siqueira-Neto,J.L., Hook,V. and Gerwick,W.H. \<br\>Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain\<br\>J Med Chem (2019) 62, 9026-9044. PubMed  Europe PubMed DOI  I
  121. Dana,D., Garcia,J., Bhuiyan,A.I., Rathod,P., Joo,L., Novoa,D.A., Paroly,S., Fath,K.R., Chang,E.J. and Pathak,S.K. \<br\>Cell penetrable, clickable and tagless activity-based probe of human cathepsin L\<br\>Bioorg Chem (2019) 85, 505-514. PubMed  Europe PubMed DOI  L  I
  122. Luo,H., Tie,L., Cao,M., Hunter,A.K., Pabst,T.M., Du,J., Field,R., Li,Y. and Wang,W.K. \<br\>Cathepsin L causes proteolytic cleavage of Chinese hamste-ovary-cell expressed proteins during processing and storage: identification characterization and mitigation\<br\>Biotechnol Prog (2019) 35, e2732. PubMed  Europe PubMed DOI
  123. Ma,K.X., Song,G.G., Wu,M., Zhang,H.C., Chen,G.W. and Liu,D.Z. \<br\>Identification of a potential tissue-specific biomarker cathepsin L-like gene from the planarian Dugesia japonica: molecular cloning, characterization, and expression in response to heavy metal exposure\<br\>Ecotoxicol Environ Saf (2019) 180, 73-79. PubMed  Europe PubMed DOI
  124. Papanastasiou,M., Mullahoo,J., DeRuff,K.C., Bajrami,B., Karageorgos,I., Johnston,S.E., Peckner,R., Myers,S.A., Carr,S.A. and Jaffe,J.D. \<br\>Chasing tails: cathepsin-L improves structural analysis of histones by HX-MS\<br\>Mol Cell Proteomics (2019) 18, 2089-2098. PubMed  Europe PubMed DOI
  125. Parks,A.N., Nahata,J., Edouard,N.E., Temenoff,J.S. and Platt,M.O. \<br\>Sequential, but not concurrent, incubation of cathepsin K and L with type I collagen results in extended proteolysis\<br\>Sci Rep (2019) 9, 5399. PubMed  Europe PubMed DOI  PMC  EPMC
  126. Pranjol,M.Z.I., Gutowski,N.J., Hannemann,M. and Whatmore,J.L. \<br\>Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway\<br\>Curr Cancer Drug Targets (2019) 19, 231-242. PubMed  Europe PubMed DOI
  127. Shockey,W.A., Kieslich,C.A., Wilder,C.L., Watson,V. and Platt,M.O. \<br\>Dynamic model of protease state and inhibitor trafficking to predict protease activity in breast cancer cells\<br\>Cell Mol Bioeng (2019) 12, 275-288. PubMed  Europe PubMed DOI  PMC  EPMC  I
  128. Tokarzewicz,A., Romanowicz,L., Sankiewicz,A., Hermanowicz,A., Sobolewski,K. and Gorodkiewicz,E. \<br\>A new analytical method for determination of cathepsin L based on the surface plasmon resonance imaging biosensor\<br\>Int J Mol Sci (2019) 20, PubMed  Europe PubMed DOI  A
  129. Weiss-Sadan,T., Itzhak,G., Kaschani,F., Yu,Z., Mahameed,M., Anaki,A., Ben-Nun,Y., Merquiol,E., Tirosh,B., Kessler,B., Kaiser,M. and Blum,G. \<br\>Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation\<br\>Mol Cell Proteomics (2019) 18, 1330-1344. PubMed  Europe PubMed DOI  I
  130. Xue,Q., Wu,X.Q., Zhang,W.J., Deng,L.N. and Wu,M.M. \<br\>Cathepsin L-like cysteine proteinase genes are associated with the development and pathogenicity of pine wood nematode, Bursaphelenchus xylophilus\<br\>Int J Mol Sci (2019) 20, PubMed  Europe PubMed DOI
  131. Yuan,L., Liu,J., He,W., Bao,Y., Sheng,L., Zou,C., Hu,B., Ge,W., Liu,Y., Wang,J., Lin,B., Li,Y. and Ma,E. \<br\>Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells\<br\>Bioorg Chem (2019) 84, 239-253. PubMed  Europe PubMed DOI  I
  132. Yuan,L., Zou,C., Ge,W., Liu,Y., Hu,B., Wang,J., Lin,B., Li,Y. and Ma,E. \<br\>A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis\<br\>Bioorg Chem (2019) 103417. PubMed  Europe PubMed DOI  I
  133. 2018
  134. Aich,P. and Biswas,S. \<br\>Highly conserved Arg residue of ERFNIN motif of pro-domain is important for pH-induced zymogen activation process in cysteine cathepsins K and L\<br\>Cell Biochem Biophys (2018) 76, 219-229. PubMed  Europe PubMed DOI
  135. Douglas,S.A., Lamothe,S.E., Singleton,T.S., Averett,R.D. and Platt,M.O. \<br\>Human cathepsins K, L, and S: related proteases, but unique fibrinolytic activity\<br\>Biochim Biophys Acta (2018) 1862, 1925-1932. PubMed  Europe PubMed DOI
  136. Freeley,S., Cardone,J., Gunther,S.C., West,E.E., Reinheckel,T., Watts,C., Kemper,C. and Kolev,M.V. \<br\>Asparaginyl endopeptidase (legumain) supports human Th1 induction via cathepsin L-mediated intracellular C3 activation\<br\>Front Immunol (2018) 9, 2449. PubMed  Europe PubMed DOI  PMC  EPMC
  137. Huisman,M., Kodanko,J.P., Arora,K., Herroon,M., Alnaed,M., Endicott,J., Podgorski,I. and Kodanko,J.J. \<br\>Affinity-enhanced luminescent Re(I)- and Ru(II)-based inhibitors of the cysteine protease cathepsin L\<br\>Inorg Chem (2018) 57, 7881-7891. PubMed  Europe PubMed DOI  I
  138. Peyer,S.M., Kremer,N. and McFall-Ngai,M.J. \<br\>Involvement of a host cathepsin L in symbiont-induced cell death\<br\>Microbiologyopen (2018) e00632. PubMed  Europe PubMed DOI
  139. Podvin,S., Wojnicz,A. and Hook,V. \<br\>Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production\<br\>Heliyon (2018) 4, e00673. PubMed  Europe PubMed DOI  PMC  EPMC
  140. Poreba,M., Rut,W., Vizovisek,M., Groborz,K., Kasperkiewicz,P., Finlay,D., Vuori,K., Turk,D., Turk,B., Salvesen,G.S. and Drag,M. \<br\>Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes\<br\>Chem Sci (2018) 9, 2113-2129. PubMed  Europe PubMed DOI  PMC  EPMC  L
  141. Streubel,M.K., Bischof,J., Weiss,R., Duschl,J., Liedl,W., Wimmer,H., Breitenbach,M., Weber,M., Geltinger,F., Richter,K. and Rinnerthaler,M. \<br\>Behead and live long or the tale of cathepsin L\<br\>Yeast (2018) 35, 237-249. PubMed  Europe PubMed DOI
  142. 2017
  143. Dai,L.S., Chu,S.H., Yu,X.M. and Li,Y.Y. \<br\>A role of cathepsin L gene in innate immune response of crayfish (Procambarus clarkii)\<br\>Fish Shellfish Immunol (2017) 71, 246-254. PubMed  Europe PubMed DOI
  144. Dos Santos,D.A., Deobald,A.M., Cornelio,V.E., Avila,R.M.D., Cornea,R.C., Bernasconi,G.C.R., Paixao,M.W., Vieira,P.C. and Correa,A.G. \<br\>Asymmetric synthesis and evaluation of epoxy-alpha-acyloxycarboxamides as selective inhibitors of cathepsin L\<br\>Bioorg Med Chem (2017) 25, 4620-4627. PubMed  Europe PubMed DOI  I
  145. Giroud,M., Ivkovic,J., Martignoni,M., Fleuti,M., Trapp,N., Haap,W., Kuglstatter,A., Benz,J., Kuhn,B., Schirmeister,T. and Diederich,F. \<br\>Inhibition of the cysteine protease human cathepsin L by triazine nitriles: amide???heteroarene pi-stacking interactions and chalcogen bonding in the S3 pocket\<br\>ChemMedChem (2017) 12, 257-270. PubMed  Europe PubMed DOI  I
  146. Hashimoto,Y. \<br\>Gelatin zymography using leupeptin for the detection of various cathepsin L forms\<br\>Methods Mol Biol (2017) 1594, 243-254. PubMed  Europe PubMed DOI  L  I
  147. Kikuta,S., Murai,Y. and Tanaka,E. \<br\>Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons\<br\>Neurosci Lett (2017) 636, 120-126. PubMed  Europe PubMed DOI  I
  148. Kuhn,B., Tichy,M., Wang,L., Robinson,S., Martin,R.E., Kuglstatter,A., Benz,J., Giroud,M., Schirmeister,T., Abel,R., Diederich,F. and Hert,J. \<br\>Prospective evaluation of free energy calculations for the prioritization of cathepsin L inhibitors\<br\>J Med Chem (2017) 60, 2485-2497. PubMed  Europe PubMed DOI  I
  149. Lee,C.W., Stankowski,J.N., Chew,J., Cook,C.N., Lam,Y.W., Almeida,S., Carlomagno,Y., Lau,K.F., Prudencio,M., Gao,F.B., Bogyo,M., Dickson,D.W. and Petrucelli,L. \<br\>The lysosomal protein cathepsin L is a progranulin protease\<br\>Mol Neurodegener (2017) 12, 55. PubMed  Europe PubMed DOI  PMC  EPMC
  150. Li,Y.Y., Fang,J. and Ao,G.Z. \<br\>Cathepsin B and L inhibitors: a patent review (2010 - present)\<br\>Expert Opin Ther Pat (2017) 27, 643-656. PubMed  Europe PubMed DOI  V  I
  151. Liang,F.R., Hong,Y.H., Ye,C.C., Deng,H., Yuan,J.P., Hao,Y.F. and Wang,J.H. \<br\>Molecular characterization and gene expression of cathepsin L in Nile tilapia (Oreochromis niloticus)\<br\>Fish Shellfish Immunol (2017) 67, 280-292. PubMed  Europe PubMed DOI
  152. McGlinchey,R.P., Dominah,G.A. and Lee,J.C. \<br\>Taking a bite out of amyloid: mechanistic insights into alpha-synuclein degradation by cathepsin L\<br\>Biochemistry (2017) 56, 3881-3884. PubMed  Europe PubMed DOI
  153. Parker,E.N., Odutola,S.O., Wang,Y., Strecker,T.E., Mukherjee,R., Shi,Z., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L\<br\>Bioorg Med Chem Lett (2017) 27, 1304-1310. PubMed  Europe PubMed DOI  I
  154. Qi,Z., Huang,B., Zhang,Q., Wang,Z., Wang,P. and Gao,Q. \<br\>Molecular characterization, expression and evolutionary analysis of 3 cathepsin genes (CTSH, CTSL and CTSS) from Chinese giant salamander (Andrias davidianus)\<br\>Gene Rep (2017) 7, 25-31. DOI
  155. Qiao,Y., Wang,J., Mao,Y., Liu,M., Song,X., Su,Y., Wang,C. and Zheng,Z. \<br\>Identification and molecular characterization of cathepsin L gene and its expression analysis during early ontogenetic development of kuruma shrimp Marsupenaeus japonicus\<br\>Acta Oceanol Sin (2017) 36, 52-60. DOI
  156. Xu,S., Zhang,H., Yang,X., Qian,Y. and Xiao,Q. \<br\>Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-kappaB pathways\<br\>Neurobiol Aging (2017) 62, 159-167. PubMed  Europe PubMed DOI  T
  157. 2016
  158. Burton,L.J., Dougan,J., Jones,J., Smith,B.N., Randle,D., Henderson,V. and Odero-Marah,V.A. \<br\>Targeting the nuclear cathepsin L- CCAAT-displacement protein/cut homeobox transcription factor-epithelial mesenchymal transition pathway in prostate and breast cancer cells with Z-FY-CHO inhibitor\<br\>Mol Cell Biol (2016) PubMed  Europe PubMed DOI  I
  159. Castro-Gomes,T., Corrotte,M., Tam,C. and Andrews,N.W. \<br\>Plasma membrane repair is regulated extracellularly by proteases released from lysosomes\<br\>PLoS ONE (2016) 11, e0152583. PubMed  Europe PubMed DOI  PMC  EPMC
  160. Garsen,M., Rops,A.L., Dijkman,H., Willemsen,B., van Kuppevelt,T.H., Russel,F.G., Rabelink,T.J., Berden,J.H., Reinheckel,T. and van der Vlag,J. \<br\>Cathepsin L is crucial for the development of early experimental diabetic nephropathy\<br\>Kidney Int (2016) 90, 1012-1022. PubMed  Europe PubMed DOI  T
  161. Giroud,M., Harder,M., Kuhn,B., Haap,W., Trapp,N., Schweizer,W.B., Schirmeister,T. and Diederich,F. \<br\>Fluorine scan of inhibitors of the cysteine protease human cathepsin L: dipolar and quadrupolar effects in the pi-stacking of fluorinated phenyl rings on peptide amide bonds\<br\>ChemMedChem (2016) 11, 1042-1047. PubMed  Europe PubMed DOI  I
  162. Hofmann,N., Galetskiy,D., Rauch,D., Wittmann,T., Marquardt,A., Griese,M. and Zarbock,R. \<br\>Analysis of the proteolytic processing of ABCA3: identification of cleavage site and involved proteases\<br\>PLoS ONE (2016) 11, e0152594. PubMed  Europe PubMed DOI  P
  163. Mori,J., Tanikawa,C., Funauchi,Y., Lo,P.H., Nakamura,Y. and Matsuda,K. \<br\>Cystatin C as a p53-inducible apoptotic mediator that regulates cathepsin L activity\<br\>Cancer Sci (2016) 107, 298-306. PubMed  Europe PubMed DOI
  164. Ohrvik,H., Logeman,B., Turk,B., Reinheckel,T. and Thiele,D.J. \<br\>Cathepsin protease controls copper and cisplatin accumulation via cleavage of the Ctr1 metal-binding ectodomain\<br\>J Biol Chem (2016) 291, 13905-13916. PubMed  Europe PubMed DOI
  165. Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J. \<br\>Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones\<br\>RSC Adv (2016) 6, 34588-34599. DOI  I
  166. Shirato,K., Kanou,K., Kawase,M. and Matsuyama,S. \<br\>Clinical isolates of human coronavirus 229E bypass the endosome for cell entry\<br\>J Virol (2016) PubMed  Europe PubMed DOI
  167. Sosnowski,P. and Turk,D. \<br\>Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of cathepsin L\<br\>FEBS Lett (2016) 590, 1253-1261. PubMed  Europe PubMed DOI  S
  168. Sudhan,D.R., Pampo,C., Rice,L. and Siemann,D.W. \<br\>Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model\<br\>Int J Cancer (2016) 138, 2665-2677. PubMed  Europe PubMed DOI  I
  169. Sudhan,D.R., Rabaglino,M.B., Wood,C.E. and Siemann,D.W. \<br\>Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94\<br\>Clin Exp Metastasis (2016) 33, 461-473. PubMed  Europe PubMed DOI  I
  170. Tamhane,T., Lllukkumbura,R., Lu,S., Maelandsmo,G.M., Haugen,M.H. and Brix,K. \<br\>Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells\<br\>Biochimie (2016) 122, 208-218. PubMed  Europe PubMed DOI
  171. Ueki,N., Wang,W., Swenson,C., McNaughton,C., Sampson,N.S. and Hayman,M.J. \<br\>Synthesis and preclinical evaluation of a highly improved anticancer prodrug activated by histone deacetylases and cathepsin L\<br\>Theranostics (2016) 6, 808-816. PubMed  Europe PubMed DOI  PMC  EPMC  I
  172. Withana,N.P., Garland,M., Verdoes,M., Ofori,L.O., Segal,E. and Bogyo,M. \<br\>Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes\<br\>Nat Protoc (2016) 11, 184-191. PubMed  Europe PubMed DOI  L
  173. Withana,N.P., Ma,X., McGuire,H.M., Verdoes,M., van der Linden,W.A., Ofori,L.O., Zhang,R., Li,H., Sanman,L.E., Wei,K., Yao,S., Wu,P., Li,F., Huang,H., Xu,Z., Wolters,P.J., Rosen,G.D., Collard,H.R., Zhu,Z., Cheng,Z. and Bogyo,M. \<br\>Non-invasive imaging of idiopathic pulmonary fibrosis using cathepsin protease probes\<br\>Sci Rep (2016) 6, 19755. PubMed  Europe PubMed DOI  PMC  EPMC  L
  174. Yang,J., Liu,H., Zheng,G., Xiang,X., Lv,Z. and Wang,T. \<br\>Cathepsin L of the sea cucumber Apostichopus japonicus-molecular characterization and transcriptional response to Vibrio splendidus infection\<br\>Fish Shellfish Immunol (2016) 49, 387-395. PubMed  Europe PubMed DOI
  175. Zhang,H., Zhang,L., Wei,L., Gao,X., Tang,L., Gong,W., Min,N., Zhang,L. and Yuan,Y. \<br\>Knockdown of cathepsin L sensitizes ovarian cancer cells to chemotherapy\<br\>Oncol Lett (2016) 11, 4235-4239. PubMed  Europe PubMed DOI  K
  176. Zhou,N., Pan,T., Zhang,J., Li,Q., Zhang,X., Bai,C., Huang,F., Peng,T., Zhang,J., Liu,C., Tao,L. and Zhang,H. \<br\>Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)\<br\>J Biol Chem (2016) 291, 9218-9232. PubMed  Europe PubMed DOI  I
  177. 2015
  178. Andrault,P.M., Samsonov,S.A., Weber,G., Coquet,L., Nazmi,K., Bolscher,J.G., Lalmanach,A.C., Jouenne,T., Bromme,D., Pisabarro,M.T., Lalmanach,G. and Lecaille,F. \<br\>Antimicrobial peptide LL-37 is both a substrate of cathepsins S and K and a selective inhibitor of cathepsin L\<br\>Biochemistry (2015) 54, 2785-2798. PubMed  Europe PubMed DOI
  179. Brindle,N.R., Joyce,J.A., Rostker,F., Lawlor,E.R., Swigart-Brown,L., Evan,G., Hanahan,D. and Shchors,K. \<br\>Deficiency for the cysteine protease cathepsin L impairs myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer\<br\>PLoS ONE (2015) 10, e0120348. PubMed  Europe PubMed DOI  PMC  EPMC  K
  180. Celis-Barros,C., Saavedra-Rivas,L., Salgado,J.C., Cassels,B.K. and Zapata-Torres,G. \<br\>Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition\<br\>J Comput Aided Mol Des (2015) 29, 37-46. PubMed  Europe PubMed DOI  I
  181. Corry,J., Johnson,S.M., Cornwell,J. and Peeples,M.E. \<br\>Preventing cleavage of the respiratory syncytial virus attachment protein in Vero cells rescues the infectivity of progeny virus for primary human airway cultures\<br\>J Virol (2015) 90, 1311-1320. PubMed  Europe PubMed DOI
  182. Gu,Y.H., Kanazawa,M., Hung,S.Y., Wang,X., Fukuda,S., Koziol,J.A. and del Zoppo,G.J. \<br\>Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia\<br\>J Cereb Blood Flow Metab (2015) 35, 1888-1900. PubMed  Europe PubMed DOI
  183. Hashimoto,Y., Kondo,C. and Katunuma,N. \<br\>An active 32-kDa cathepsin L is secreted directly from HT 1080 fibrosarcoma cells and not via lysosomal exocytosis\<br\>PLoS ONE (2015) 10, e0145067. PubMed  Europe PubMed DOI
  184. Hou,L., Cooley,J., Swanson,R., Ong,P.C., Pike,R.N., Bogyo,M., Olson,S.T. and Remold-O'Donnell,E. \<br\>The protease cathepsin L regulates Th17 cell differentiation\<br\>J Autoimmun (2015) 65, 56-63. PubMed  Europe PubMed DOI
  185. Korenc,M., Lenarcic,B. and Novinec,M. \<br\>Human cathepsin L, a papain-like collagenase without proline specificity\<br\>FEBS J (2015) 282, 4328-4340. PubMed  Europe PubMed DOI
  186. McGlinchey,R.P. and Lee,J.C. \<br\>Cysteine cathepsins are essential in lysosomal degradation of alpha-synuclein\<br\>Proc Natl Acad Sci U S A (2015) 112, 9322-9327. PubMed  Europe PubMed DOI  P
  187. Ofori,L.O., Withana,N.P., Prestwood,T.R., Verdoes,M., Brady,J.J., Winslow,M.M., Sorger,J. and Bogyo,M. \<br\>Design of protease activated optical contrast agents that exploit a latent lysosomotropic effect for use in fluorescence-guided surgery\<br\>ACS Chem Biol (2015) 10, 1977-1988. PubMed  Europe PubMed DOI  L
  188. Parker,E.N., Song,J., Kishore Kumar,G.D., Odutola,S.O., Chavarria,G.E., Charlton-Sevcik,A.K., Strecker,T.E., Barnes,A.L., Sudhan,D.R., Wittenborn,T.R., Siemann,D.W., Horsman,M.R., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L\<br\>Bioorg Med Chem (2015) 23, 6974-6992. PubMed  Europe PubMed DOI  I
  189. Rodrigues,T., Lin,Y.C., Hartenfeller,M., Renner,S., Lim,Y.F. and Schneider,G. \<br\>Repurposing de novo designed entities reveals phosphodiesterase 3B and cathepsin L modulators\<br\>Chem Commun (Camb) (2015) 51, 7478-7481. PubMed  Europe PubMed DOI
  190. Shen,J.D., Cai,Q.F., Yan,L.J., Du,C.H., Liu,G.M., Su,W.J., Ke,C. and Cao,M.J. \<br\>Cathepsin L is an immune-related protein in Pacific abalone (Haliotis discus hannai) - purification and characterization\<br\>Fish Shellfish Immunol (2015) 47, 986-995. PubMed  Europe PubMed DOI
  191. Sudhan,D.R. and Siemann,D.W. \<br\>Cathepsin L targeting in cancer treatment\<br\>Pharmacol Ther (2015) 155, 105-116. PubMed  Europe PubMed DOI
  192. Sun,B.G. and Hu,Y.H. \<br\>Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus)\<br\>Fish Physiol Biochem (2015) 41, 1463-1473. PubMed  Europe PubMed DOI
  193. Vizovisek,M., Vidmar,R., Van Quickelberghe,E., Impens,F., Andjelkovic,U., Sobotic,B., Stoka,V., Gevaert,K., Turk,B. and Fonovic,M. \<br\>Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S\<br\>Proteomics (2015) 15, 2479-2490. PubMed  Europe PubMed DOI  P
  194. Wang,H., Sang,N., Zhang,C., Raghupathi,R., Tanzi,R.E. and Saunders,A. \<br\>Cathepsin L mediates the degradation of novel APP C-terminal fragments\<br\>Biochemistry (2015) 54, 2806-2816. PubMed  Europe PubMed DOI  I
  195. Wang,R., Song,L., Su,B., Zhao,H., Zhang,D., Peatman,E. and Li,C. \<br\>Mucosal expression signatures of two cathepsin L in channel catfish (Ictalurus punctatus) following bacterial challenge\<br\>Fish Shellfish Immunol (2015) 47, 582-589. PubMed  Europe PubMed DOI
  196. Yang,N., Wang,P., Wang,W.J., Song,Y.Z. and Liang,Z.Q. \<br\>Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-kappaB signaling pathway\<br\>Acta Pharmacol Sin (2015) 36, 400-410. PubMed  Europe PubMed DOI  I
  197. Zhang,Q., Han,M., Wang,W., Song,Y., Chen,G., Wang,Z. and Liang,Z. \<br\>Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor-beta-mediated epithelial-mesenchymal transition\<br\>Oncol Rep (2015) 33, 1851-1859. PubMed  Europe PubMed DOI
  198. 2014
  199. Chua,K.C., Pietsch,M., Zhang,X., Hautmann,S., Chan,H.Y., Bruning,J.B., Gutschow,M. and Abell,A.D. \<br\>Macrocyclic protease inhibitors with reduced peptide character\<br\>Angew Chem Int Ed Engl (2014) 53, 7828-7831. PubMed  Europe PubMed DOI  I
  200. Dana,D., De,S., Rathod,P., Davalos,A.R., Novoa,D.A., Paroly,S., Torres,V.M., Afzal,N., Lankalapalli,R.S., Rotenberg,S.A., Chang,E.J., Subramaniam,G. and Kumar,S. \<br\>Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L - a hybrid design approach\<br\>Chem Commun (Camb) (2014) 50, 10875-10878. PubMed  Europe PubMed DOI  I
  201. Duarte,L.F., Young,A.R., Wang,Z., Wu,H.A., Panda,T., Kou,Y., Kapoor,A., Hasson,D., Mills,N.R., Ma'ayan,A., Narita,M. and Bernstein,E. \<br\>Histone H3.3 and its proteolytically processed form drive a cellular senescence programme\<br\>Nat Commun (2014) 5, 5210. PubMed  Europe PubMed DOI  PMC  EPMC
  202. Elshabrawy,H.A., Fan,J., Haddad,C.S., Ratia,K., Broder,C.C., Caffrey,M. and Prabhakar,B.S. \<br\>Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay\<br\>J Virol (2014) 88, 4353-4365. PubMed  Europe PubMed DOI  I
  203. Hu,X., Hu,X., Hu,B., Wen,C., Xie,Y., Wu,D., Tao,Z., Li,A. and Gao,Q. \<br\>Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata\<br\>Fish Shellfish Immunol (2014) 40, 446-454. PubMed  Europe PubMed DOI
  204. Kumaresan,V., Bhatt,P., Palanisamy,R., Gnanam,A.J., Pasupuleti,M. and Arockiaraj,J. \<br\>A murrel cysteine protease, cathepsin L: Bioinformatics characterization, gene expression and proteolytic activity\<br\>Biologia (2014) 69, 395-406. DOI
  205. Legowska,M., Wysocka,M., Burster,T., Pikula,M., Rolka,K. and Lesner,A. \<br\>Ultrasensitive internally quenched substrates of human cathepsin L\<br\>Anal Biochem (2014) 466, 30-37. PubMed  Europe PubMed DOI  A
  206. Miller,B., Friedman,A.J., Choi,H., Hogan,J., McCammon,J.A., Hook,V. and Gerwick,W.H. \<br\>The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L\<br\>J Nat Prod (2014) 77, 92-99. PubMed  Europe PubMed DOI  I
  207. Muller,S., Faulhaber,A., Sieber,C., Pfeifer,D., Hochberg,T., Gansz,M., Deshmukh,S.D., Dauth,S., Brix,K., Saftig,P., Peters,C., Henneke,P. and Reinheckel,T. \<br\>The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction\<br\>FASEB J (2014) 28, 162-175. PubMed  Europe PubMed DOI
  208. Pietra,D., Borghini,A., Ricci,C. and Bianucci,A.M. \<br\>Enzyme kinetics studies on 29-kDa human liver cathepsin L\<br\>Chem Biol Drug Des (2014) 84, 648-658. PubMed  Europe PubMed DOI
  209. Ramalho,S.D., De Sousa,L.R., Nebo,L., Maganhi,S.H., Caracelli,I., Zukerman-Schpector,J., Lima,M.I., Alves,M.F., da Silva,M.F., Fernandes,J.B. and Vieira,P.C. \<br\>Triterpenoids as novel natural inhibitors of human cathepsin L\<br\>Chem Biodivers (2014) 11, 1354-1363. PubMed  Europe PubMed DOI  I
  210. Shivanna,V., Kim,Y. and Chang,K.O. \<br\>Endosomal acidification and cathepsin L activity is required for calicivirus replication\<br\>Virology (2014) 464-465, 287-295. PubMed  Europe PubMed DOI
  211. Tholen,M., Hillebrand,L.E., Tholen,S., Sedelmeier,O., Arnold,S.J. and Reinheckel,T. \<br\>Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo\<br\>Nat Commun (2014) 5, 4931. PubMed  Europe PubMed DOI
  212. Tholen,S., Biniossek,M.L., Gansz,M., Ahrens,T.D., Schlimpert,M., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O. \<br\>Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis\<br\>Cell Mol Life Sci (2014) 71, 899-916. PubMed  Europe PubMed DOI  K
  213. 2013
  214. Arockiaraj,J., Gnanam,A.J., Muthukrishnan,D., Thirumalai,M.K., Pasupuleti,M., Milton,J. and Kasi,M. \<br\>Macrobrachium rosenbergii cathepsin L: molecular characterization and gene expression in response to viral and bacterial infections\<br\>Microbiol Res (2013) 168, 569-579. PubMed  Europe PubMed DOI
  215. Badano,M.N., Camicia,G.L., Lombardi,G., Maglioco,A., Cabrera,G., Costa,H., Meiss,R.P., Piazzon,I. and Nepomnaschy,I. \<br\>B-cell lymphopoiesis is regulated by cathepsin L\<br\>PLoS ONE (2013) 8, e61347. PubMed  Europe PubMed DOI  PMC  EPMC
  216. Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y. \<br\>Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors\<br\>Bioorg Chem (2013) 51, 24-30. PubMed  Europe PubMed DOI  I
  217. Brocklehurst,K. and Philpott,M.P. \<br\>Cysteine proteases: mode of action and role in epidermal differentiation\<br\>Cell Tissue Res (2013) 351, 237-244. PubMed  Europe PubMed DOI
  218. Ehmke,V., Winkler,E., Banner,D.W., Haap,W., Schweizer,W.B., Rottmann,M., Kaiser,M., Freymond,C., Schirmeister,T. and Diederich,F. \<br\>Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L\<br\>ChemMedChem (2013) 8, 967-975. PubMed  Europe PubMed DOI  I
  219. Grotsky,D.A., Gonzalez-Suarez,I., Novell,A., Neumann,M.A., Yaddanapudi,S.C., Croke,M., Martinez-Alonso,M., Redwood,A.B., Ortega-Martinez,S., Feng,Z., Lerma,E., Ramon,Y.C., Zhang,J., Matias-Guiu,X., Dusso,A. and Gonzalo,S. \<br\>BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells\<br\>J Cell Biol (2013) 200, 187-202. PubMed  Europe PubMed DOI  PMC  EPMC
  220. Niu,D., Jin,K., Wang,L., Feng,B. and Li,J. \<br\>Molecular characterization and expression analysis of four cathepsin L genes in the razor clam, Sinonovacula constricta\<br\>Fish Shellfish Immunol (2013) 35, 581-588. PubMed  Europe PubMed DOI
  221. Ohkouchi,S., Shibata,M., Sasaki,M., Koike,M., Safig,P., Peters,C., Nagata,S. and Uchiyama,Y. \<br\>Biogenesis and proteolytic processing of lysosomal DNase II\<br\>PLoS ONE (2013) 8, e59148. PubMed  Europe PubMed DOI  PMC  EPMC
  222. Song,J., Jones,L.M., Chavarria,G.E., Charlton-Sevcik,A.K., Jantz,A., Johansen,A., Bayeh,L., Soeung,V., Snyder,L.K., Lade,S.D., Jr., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks\<br\>Bioorg Med Chem Lett (2013) 23, 2801-2807. PubMed  Europe PubMed DOI  I
  223. Tholen,S., Biniossek,M.L., Gansz,M., Gomez-Auli,A., Bengsch,F., Noel,A., Kizhakkedathu,J.N., Boerries,M., Busch,H., Reinheckel,T. and Schilling,O. \<br\>Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome\<br\>Mol Cell Proteomics (2013) 12, 611-625. PubMed  Europe PubMed DOI  K
  224. Torkar,A., Lenarcic,B., Lah,T., Dive,V. and Devel,L. \<br\>Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?\<br\>Bioorg Med Chem Lett (2013) 23, 2968-2973. PubMed  Europe PubMed DOI  I
  225. Wang,Y.R., Qin,S., Han,R., Wu,J.C., Liang,Z.Q., Qin,Z.H. and Wang,Y. \<br\>Cathepsin L plays a role in quinolinic acid-induced NF-Kappab activation and excitotoxicity in rat striatal neurons\<br\>PLoS ONE (2013) 8, e75702. PubMed  Europe PubMed DOI  PMC  EPMC  I
  226. Wei,D.H., Jia,X.Y., Liu,Y.H., Guo,F.X., Tang,Z.H., Li,X.H., Wang,Z., Liu,L.S., Wang,G.X., Jian,Z.S. and Ruan,C.G. \<br\>Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis\<br\>Int J Mol Med (2013) 31, 400-406. PubMed  Europe PubMed DOI
  227. Xu,X., Greenland,J., Baluk,P., Adams,A., Bose,O., McDonald,D.M. and Caughey,G.H. \<br\>Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis\<br\>Am J Respir Cell Mol Biol (2013) 49, 437-444. PubMed  Europe PubMed DOI
  228. 2012
  229. Benavides,F., Perez,C., Blando,J., Contreras,O., Shen,J., Coussens,L.M., Fischer,S.M., Kusewitt,D.F., Digiovanni,J. and Conti,C.J. \<br\>Protective role of cathepsin L in mouse skin carcinogenesis\<br\>Mol Carcinog (2012) 51, 352-361. PubMed  Europe PubMed DOI  M
  230. Chavarria,G.E., Horsman,M.R., Arispe,W.M., Kumar,G.D., Chen,S.E., Strecker,T.E., Parker,E.N., Chaplin,D.J., Pinney,K.G. and Trawick,M.L. \<br\>Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L\<br\>Eur J Med Chem (2012) 58, 568-572. PubMed  Europe PubMed DOI  I
  231. Ehmke,V., Quinsaat,J.E., Rivera-Fuentes,P., Heindl,C., Freymond,C., Rottmann,M., Brun,R., Schirmeister,T. and Diederich,F. \<br\>Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors\<br\>Org Biomol Chem (2012) 10, 5764-5768. PubMed  Europe PubMed DOI  I
  232. Gnirss,K., Kuhl,A., Karsten,C., Glowacka,I., Bertram,S., Kaup,F., Hofmann,H. and Pohlmann,S. \<br\>Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression\<br\>Virology (2012) 424, 3-10. PubMed  Europe PubMed DOI
  233. Hook,V., Funkelstein,L., Wegrzyn,J., Bark,S., Kindy,M. and Hook,G. \<br\>Cysteine cathepsins in the secretory vesicle produce active peptides: cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease\<br\>Biochim Biophys Acta (2012) 1824, 89-104. PubMed  Europe PubMed DOI
  234. Hook,V.Y.H. \<br\>Prohormone thiol protease\<br\>[ISSN:978-0-12-407743-0] (2012) 3, 1817-1821. DOI
  235. Hu,Y., Ji,R., Jiang,H., Zhang,J., Chen,J. and Ye,X. \<br\>Participation of cathepsin L in modori phenomenon in carp (Cyprinus carpio) surimi gel\<br\>Food Chem (2012) 134, 2014-2020. PubMed  Europe PubMed DOI
  236. Kirschke,H. \<br\>Cathepsin L\<br\>[ISSN:978-0-12-407743-0] (2012) 3, 1808-1817. DOI
  237. Liang,J.Z., Rao,Y.Z., Lun,Z.R. and Yang,T.B. \<br\>Cathepsin L in the orange-spotted grouper, Epinephelus coioides: molecular cloning and gene expression after a Vibrio anguillarum challenge\<br\>Fish Physiol Biochem (2012) 38, 1795-1806. PubMed  Europe PubMed DOI
  238. Marques,E.F., Bueno,M.A., Duarte,P.D., Silva,L.R., Martinelli,A.M., Dos Santos,C.Y., Severino,R.P., Bromme,D., Vieira,P.C. and Correa,A.G. \<br\>Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V\<br\>Eur J Med Chem (2012) 54, 10-21. PubMed  Europe PubMed DOI  I
  239. Mbewe-Campbell,N., Wei,Z., Zhang,K., Friese,R.S., Mahata,M., Schork,A.J., Rao,F., Chiron,S., Biswas,N., Kim,H.S., Mahata,S.K., Waalen,J., Nievergelt,C.M., Hook,V.Y. and O'Connor,D.T. \<br\>Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure\<br\>J Hypertens (2012) 30, 1961-1969. PubMed  Europe PubMed DOI
  240. Morin,V., Sanchez-Rubio,A., Aze,A., Iribarren,C., Fayet,C., Desdevises,Y., Garcia-Huidobro,J., Imschenetzky,M., Puchi,M. and Geneviere,A.M. \<br\>The protease degrading sperm histones post-fertilization in sea urchin eggs is a nuclear cathepsin L that is further required for embryo development\<br\>PLoS ONE (2012) 7, e46850. PubMed  Europe PubMed DOI  PMC  EPMC
  241. Na,Z., Li,L., Uttamchandani,M. and Yao,S.Q. \<br\>Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities\<br\>Chem Commun (Camb) (2012) 48, 7304-7306. PubMed  Europe PubMed DOI  I
  242. Reif,M.M., Mach,L. and Oostenbrink,C. \<br\>Molecular insight into propeptide-protein interactions in cathepsins L and O\<br\>Biochemistry (2012) 51, 8636-8653. PubMed  Europe PubMed DOI
  243. Schurigt,U., Eilenstein,R., Gajda,M., Leipner,C., Sevenich,L., Reinheckel,T., Peters,C., Wiederanders,B. and Brauer,R. \<br\>Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment\<br\>Inflamm Res (2012) 61, 1021-1029. PubMed  Europe PubMed DOI
  244. Song,J., Jones,L.M., Kumar,G.D.K., Conner,E.S., Bayeh,L., Chavarria,G.E., Charlton-Sevcik,A.K., Chen,S.E., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L\<br\>ACS Med Chem Lett (2012) 3, 450-453. PubMed  Europe PubMed DOI  I
  245. Torkar,A., Bregant,S., Devel,L., Novinec,M., Lenarcic,B., Lah,T. and Dive,V. \<br\>A novel photoaffinity-based probe for selective detection of cathepsin L active form\<br\>Chembiochem (2012) 13, 2616-2621. PubMed  Europe PubMed DOI
  246. Yamaguchi,M., Date,A., Sasaki,M., Makino,T. and Shimizu,T. \<br\>Noninvasive biosensor for cathepsin L in the stratum corneum\<br\>Skin Res Technol (2012) 18, 332-338. PubMed  Europe PubMed DOI  A
  247. 2011
  248. Adams-Cioaba,M.A., Krupa,J.C., Xu,C., Mort,J.S. and Min,J. \<br\>Structural basis for the recognition and cleavage of histone H3 by cathepsin L\<br\>Nat Commun (2011) 2, 197. PubMed  Europe PubMed DOI  S
  249. Biniossek,M.L., Nagler,D.K., Becker-Pauly,C. and Schilling,O. \<br\>Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S\<br\>J Proteome Res (2011) 10, 5363-5373. PubMed  Europe PubMed DOI  P
  250. Chen,L., Zhang,M. and Sun,L. \<br\>Identification and expressional analysis of two cathepsins from half-smooth tongue sole (Cynoglossus semilaevis)\<br\>Fish Shellfish Immunol (2011) 31, 1270-1277. PubMed  Europe PubMed DOI
  251. Chung,J.H., Im,E.K., Jin,T., Lee,S.M., Kim,S.H., Choi,E.Y., Shin,M.J., Lee,K.H. and Jang,Y. \<br\>Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration\<br\>Exp Mol Med (2011) 43, 179-188. PubMed  Europe PubMed DOI
  252. Funkelstein,L. and Hook,V. \<br\>The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression\<br\>Methods Mol Biol (2011) 768, 107-125. PubMed  Europe PubMed DOI
  253. Gonzalez-Suarez,I., Redwood,A.B., Grotsky,D.A., Neumann,M.A., Cheng,E.H., Stewart,C.L., Dusso,A. and Gonzalo,S. \<br\>A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair\<br\>EMBO J (2011) 30, 3383-3396. PubMed  Europe PubMed DOI
  254. Hardegger,L.A., Kuhn,B., Spinnler,B., Anselm,L., Ecabert,R., Stihle,M., Gsell,B., Thoma,R., Diez,J., Benz,J., Plancher,J.M., Hartmann,G., Isshiki,Y., Morikami,K., Shimma,N., Haap,W., Banner,D.W. and Diederich,F. \<br\>Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments\<br\>ChemMedChem (2011) 6, 2048-2054. PubMed  Europe PubMed DOI  S
  255. Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B. \<br\>Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C\<br\>J Immunol (2011) 186, 7136-7143. PubMed  Europe PubMed DOI
  256. Savalas,L.R., Gasnier,B., Damme,M., Lubke,T., Wrocklage,C., Debacker,C., Jezegou,A., Reinheckel,T., Hasilik,A., Saftig,P. and Schroder,B. \<br\>Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L\<br\>Biochem J (2011) 439, 113-128. PubMed  Europe PubMed DOI
  257. Schechter,I. and Ziv,E. \<br\>Cathepsins S, B and L with aminopeptidases display beta-secretase activity associated with the pathogenesis of Alzheimer's disease\<br\>Biol Chem (2011) 392, 555-569. PubMed  Europe PubMed DOI
  258. Shenoy,R.T. and Sivaraman,J. \<br\>Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors\<br\>J Struct Biol (2011) 173, 14-19. PubMed  Europe PubMed DOI  I
  259. Sun,J., Sukhova,G.K., Zhang,J., Chen,H., Sjoberg,S., Libby,P., Xiang,M., Wang,J., Peters,C., Reinheckel,T. and Shi,G.P. \<br\>Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice\<br\>Arterioscler Thromb Vasc Biol (2011) 31, 2500-2508. PubMed  Europe PubMed DOI  K
  260. Sun,M., Chen,M., Liu,Y., Fukuoka,M., Zhou,K., Li,G., Dawood,F., Gramolini,A. and Liu,P.P. \<br\>Cathepsin-L contributes to cardiac repair and remodelling post-infarction\<br\>Cardiovasc Res (2011) 89, 374-383. PubMed  Europe PubMed DOI  K
  261. Tholen,S., Biniossek,M.L., Gessler,A.L., Muller,S., Weisser,J., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O. \<br\>Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts\<br\>Biol Chem (2011) 392, 961-971. PubMed  Europe PubMed DOI  K
  262. Whang,I., De Zoysa,M., Nikapitiya,C., Lee,Y., Kim,Y., Lee,S., Oh,C., Jung,S.J., Oh,M.J., Choi,C.Y., Yeo,S.Y., Kim,B.S., Kim,S.J. and Lee,J. \<br\>Molecular characterization and expression analysis of cathepsin B and L cysteine proteases from rock bream (Oplegnathus fasciatus)\<br\>Fish Shellfish Immunol (2011) 30, 763-772. PubMed  Europe PubMed DOI
  263. Xiang,B., Fei,X., Zhuang,W., Fang,Y., Qin,Z. and Liang,Z. \<br\>Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells\<br\>Brain Res (2011) 1387, 29-38. PubMed  Europe PubMed DOI  I
  264. 2010
  265. Ahn,S.J., Sung,J.H., Kim,N.Y., Lee,A.R., Jeon,S.J., Lee,J.S., Kim,J.K., Chung,J.K. and Lee,H.H. \<br\>Molecular cloning, expression, and characterization of cathepsin L from mud loach (Misgurnus mizolepis)\<br\>Appl Biochem Biotechnol (2010) 162, 1858-1871. PubMed  Europe PubMed DOI
  266. Ceru,S., Konjar,S., Maher,K., Repnik,U., Krizaj,I., Bencina,M., Renko,M., Nepveu,A., Zerovnik,E., Turk,B. and Kopitar-Jerala,N. \<br\>Stefin B interacts with histones and cathepsin L in the nucleus\<br\>J Biol Chem (2010) 285, 10078-10086. PubMed  Europe PubMed DOI
  267. Dennemarker,J., Lohmuller,T., Mayerle,J., Tacke,M., Lerch,M.M., Coussens,L.M., Peters,C. and Reinheckel,T. \<br\>Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis\<br\>Oncogene (2010) 29, 1611-1621. PubMed  Europe PubMed DOI  K
  268. Dennemarker,J., Lohmuller,T., Muller,S., Aguilar,S.V., Tobin,D.J., Peters,C. and Reinheckel,T. \<br\>Impaired turnover of autophagolysosomes in cathepsin L deficiency\<br\>Biol Chem (2010) 391, 913-922. PubMed  Europe PubMed DOI  K
  269. Fortenberry,Y.M., Brandal,S., Bialas,R.C. and Church,F.C. \<br\>Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration\<br\>Biochim Biophys Acta (2010) 1800, 580-590. PubMed  Europe PubMed DOI
  270. Frizler,M., Stirnberg,M., Sisay,M.T. and Gutschow,M. \<br\>Development of nitrile-based peptidic inhibitors of cysteine cathepsins\<br\>Curr Top Med Chem (2010) 10, 294-322. PubMed  Europe PubMed DOI  T  I
  271. Funkelstein,L., Beinfeld,M., Minokadeh,A., Zadina,J. and Hook,V. \<br\>Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides\<br\>Neuropeptides (2010) 44, 457-466. PubMed  Europe PubMed DOI
  272. Higgins,W.J., Fox,D.M., Kowalski,P.S., Nielsen,J.E. and Worrall,D.M. \<br\>Heparin enhances serpin inhibition of the cysteine protease cathepsin L\<br\>J Biol Chem (2010) 285, 3722-3729. PubMed  Europe PubMed DOI
  273. Hood,C.L., Abraham,J., Boyington,J.C., Leung,K., Kwong,P.D. and Nabel,G.J. \<br\>Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity\<br\>J Virol (2010) 84, 2972-2982. PubMed  Europe PubMed DOI
  274. Hsing,L.C., Kirk,E.A., McMillen,T.S., Hsiao,S.H., Caldwell,M., Houston,B., Rudensky,A.Y. and LeBoeuf,R.C. \<br\>Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse\<br\>J Autoimmun (2010) 34, 96-104. PubMed  Europe PubMed DOI
  275. Hu,Y., Morioka,K. and Itoh,Y. \<br\>Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste\<br\>J Sci Food Agric (2010) 90, 370-375. PubMed  Europe PubMed DOI
  276. Kishore Kumar,G.D., Chavarria,G.E., Charlton-Sevcik,A.K., Arispe,W.M., Macdonough,M.T., Strecker,T.E., Chen,S.E., Siim,B.G., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors\<br\>Bioorg Med Chem Lett (2010) 20, 1415-1419. PubMed  Europe PubMed DOI  I
  277. Kistler,A.D., Peev,V., Forst,A.L., El Hindi,S., Altintas,M.M. and Reiser,J. \<br\>Enzymatic disease of the podocyte\<br\>Pediatr Nephrol (2010) 25, 1017-1023. PubMed  Europe PubMed DOI
  278. Konjar,S., Sutton,V.R., Hoves,S., Repnik,U., Yagita,H., Reinheckel,T., Peters,C., Turk,V., Turk,B., Trapani,J.A. and Kopitar-Jerala,N. \<br\>Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L\<br\>Immunology (2010) 131, 257-267. PubMed  Europe PubMed DOI
  279. Kumar,G.D., Chavarria,G.E., Charlton-Sevcik,A.K., Yoo,G.K., Song,J., Strecker,T.E., Siim,B.G., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L\<br\>Bioorg Med Chem Lett (2010) 20, 6610-6615. PubMed  Europe PubMed DOI  I
  280. Lankelma,J.M., Voorend,D.M., Barwari,T., Koetsveld,J., Van der Spek,A.H., De Porto,A.P., Van Rooijen,G. and Van Noorden,C.J. \<br\>Cathepsin L, target in cancer treatment?\<br\>Life Sci (2010) 86, 225-233. PubMed  Europe PubMed DOI
  281. Minokadeh,A., Funkelstein,L., Toneff,T., Hwang,S.R., Beinfeld,M., Reinheckel,T., Peters,C., Zadina,J. and Hook,V. \<br\>Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression\<br\>Mol Cell Neurosci (2010) 43, 98-107. PubMed  Europe PubMed DOI  K
  282. Sansanwal,P., Shukla,A.A., Das,T.K. and Chauhan,S.S. \<br\>Truncated human cathepsin L, encoded by a novel splice variant, exhibits altered subcellular localization and cytotoxicity\<br\>Protein Pept Lett (2010) 17, 238-245. PubMed  Europe PubMed DOI  R
  283. Sevenich,L., Hagemann,S., Stoeckle,C., Tolosa,E., Peters,C. and Reinheckel,T. \<br\>Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice\<br\>Biochimie (2010) 92, 1674-1680. PubMed  Europe PubMed DOI
  284. Shah,P.P., Wang,T., Kaletsky,R.L., Myers,M.C., Purvis,J.E., Jing,H., Huryn,D.M., Greenbaum,D.C., Smith,A.B., III, Bates,P. and Diamond,S.L. \<br\>A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells\<br\>Mol Pharmacol (2010) 78, 319-324. PubMed  Europe PubMed DOI  I
  285. Shimada,N., Ohno-Matsui,K., Iseki,S., Koike,M., Uchiyama,Y., Wang,J., Yoshida,T., Sato,T., Peters,C., Mochizuki,M. and Morita,I. \<br\>Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization\<br\>Am J Pathol (2010) 176, 2571-2580. PubMed  Europe PubMed DOI
  286. Wartmann,T., Mayerle,J., Kahne,T., Sahin-Toth,M., Ruthenburger,M., Matthias,R., Kruse,A., Reinheckel,T., Peters,C., Weiss,F.U., Sendler,M., Lippert,H., Schulz,H.U., Aghdassi,A., Dummer,A., Teller,S., Halangk,W. and Lerch,M.M. \<br\>Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice\<br\>Gastroenterology (2010) 138, 726-737. PubMed  Europe PubMed DOI
  287. Yamada,A., Ishimaru,N., Arakaki,R., Katunuma,N. and Hayashi,Y. \<br\>Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity\<br\>PLoS ONE (2010) 5, e12894. PubMed  Europe PubMed DOI  PMC  EPMC  I
  288. Yamazaki,Y., Kamei,Y., Sugita,S., Akaike,F., Kanai,S., Miura,S., Hirata,Y., Troen,B.R., Kitamura,T., Nishino,I., Suganami,T., Ezaki,O. and Ogawa,Y. \<br\>The cathepsin L gene is a direct target of FOXO1 in skeletal muscle\<br\>Biochem J (2010) 427, 171-178. PubMed  Europe PubMed DOI
  289. Zeeuwen,P.L., van Vlijmen-Willems,I.M., Cheng,T., Rodijk-Olthuis,D., Hitomi,K., Hara-Nishimura,I., John,S., Smyth,N., Reinheckel,T., Hendriks,W.J. and Schalkwijk,J. \<br\>The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea\<br\>FASEB J (2010) 24, 3744-3755. PubMed  Europe PubMed DOI  K
  290. 2009
  291. Ahimbisibwe,J.B., Inoue,K. and Aoki,T. \<br\>Detection of cathepsin L in red cell membranes from fish blood\<br\>Fish Sci (2009) 76, 155-159. DOI
  292. Asaad,N., Bethel,P.A., Coulson,M.D., Dawson,J.E., Ford,S.J., Gerhardt,S., Grist,M., Hamlin,G.A., James,M.J., Jones,E.V., Karoutchi,G.I., Kenny,P.W., Morley,A.D., Oldham,K., Rankine,N., Ryan,D., Wells,S.L., Wood,L., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S. \<br\>Dipeptidyl nitrile inhibitors of cathepsin L\<br\>Bioorg Med Chem Lett (2009) 19, 4280-4283. PubMed  Europe PubMed DOI  I
  293. Beinfeld,M.C., Funkelstein,L., Foulon,T., Cadel,S., Kitagawa,K., Toneff,T., Reinheckel,T., Peters,C. and Hook,V. \<br\>Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies\<br\>Peptides (2009) 30, 1882-1891. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  294. Bethel,P.A., Gerhardt,S., Jones,E.V., Kenny,P.W., Karoutchi,G.I., Morley,A.D., Oldham,K., Rankine,N., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S. \<br\>Design of selective cathepsin inhibitors\<br\>Bioorg Med Chem Lett (2009) 19, 4622-4625. PubMed  Europe PubMed DOI  I
  295. Biswas,N., Rodriguez-Flores,J.L., Courel,M., Gayen,J.R., Vaingankar,S.M., Mahata,M., Torpey,J.W., Taupenot,L., O'Connor,D.T. and Mahata,S.K. \<br\>Cathepsin L colocalizes with chromogranin A in chromaffin vesicles to generate active peptides\<br\>Endocrinology (2009) 150, 3547-3557. PubMed  Europe PubMed DOI  PMC  EPMC
  296. Fei,X.F., Qin,Z.H., Xiang,B., Li,L.Y., Han,F., Fukunaga,K. and Liang,Z.Q. \<br\>Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine\<br\>Brain Res (2009) 1264, 85-97. PubMed  Europe PubMed DOI
  297. Fonovic,U.P. and Kos,J. \<br\>Efficient removal of cathepsin L from active cathepsin X using immunoprecipitation technique\<br\>Acta Chim Slov (2009) 56, 985-988.
  298. Jordans,S., Jenko-Kokalj,S., Kuhl,N.M., Tedelind,S., Sendt,W., Bromme,D., Turk,D. and Brix,K. \<br\>Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions\<br\>BMC Biochem (2009) 10, 23. PubMed  Europe PubMed DOI  PMC  EPMC
  299. Liu,Y., Li,X., Peng,D., Tan,Z., Liu,H., Qing,Y., Xue,Y. and Shi,G.P. \<br\>Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease\<br\>Am J Cardiol (2009) 103, 476-481. PubMed  Europe PubMed DOI  PMC  EPMC
  300. Luft,F.C. \<br\>From furless to heartless - unraveling the diverse functions of cathepsin L\<br\>J Mol Med (2009) 87, 225-227. PubMed  Europe PubMed DOI  K
  301. Rebbaa,A., Chu,F., Sudha,T., Gallati,C., Dier,U., Dyskin,E., Yalcin,M., Bianchini,C., Shaker,O. and Mousa,S.A. \<br\>The anti-angiogenic activity of NSITC, a specific cathepsin L inhibitor\<br\>Anticancer Res (2009) 29, 4473-4481. PubMed  Europe PubMed  I
  302. Rebbaa,A., Dyskin,E., Dier,E., Gallati,C., Honko,C., Simone,T., Yalcin,M., Sudha,T. and Mousa,S.A. \<br\>Antiproliferative, antiangiogenesis, and reversal of chemoresistance by specific cathepsin L inhibitors\<br\>J Clin Oncol (2009) 27, e14643. PubMed  Europe PubMed  I
  303. Schilling,K., Korner,A., Sehmisch,S., Kreusch,A., Kleint,R., Benedix,Y., Schlabrakowski,A. and Wiederanders,B. \<br\>Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases\<br\>Biol Chem (2009) 390, 167-174. PubMed  Europe PubMed DOI
  304. See,V., Free,P., Cesbron,Y., Nativo,P., Shaheen,U., Rigden,D.J., Spiller,D.G., Fernig,D.G., White,M.R., Prior,I.A., Brust,M., Lounis,B. and Levy,R. \<br\>Cathepsin L digestion of nanobioconjugates upon endocytosis\<br\>ACS Nano (2009) 3, 2461-2468. PubMed  Europe PubMed DOI
  305. Shenoy,R.T., Chowdhury,S.F., Kumar,S., Joseph,L., Purisima,E.O. and Sivaraman,J. \<br\>A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors\<br\>J Med Chem (2009) 52, 6335-6346. PubMed  Europe PubMed DOI  S  I
  306. Takahashi,K., Ueno,T., Tanida,I., Minematsu-Ikeguchi,N., Murata,M. and Kominami,E. \<br\>Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis\<br\>Biol Pharm Bull (2009) 32, 475-479. PubMed  Europe PubMed DOI  I
  307. Tang,Q., Cai,J., Shen,D., Bian,Z., Yan,L., Wang,Y.X., Lan,J., Zhuang,G.Q., Ma,W.Z. and Wang,W. \<br\>Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling\<br\>J Mol Med (2009) 87, 249-260. PubMed  Europe PubMed DOI
  308. Ueno,T. and Takahashi,K. \<br\>A cathepsin L-specific inhibitor preferentially inhibits degradation of autophagosomal LC3 and GABARAP in HeLa and Huh-7 cells\<br\>Autophagy (2009) 5, 878-879. PubMed  Europe PubMed  I
  309. Visone,T., Charron,M. and Wright,W.W. \<br\>Activation and repression domains within the promoter of the rat cathepsin L gene orchestrate Sertoli cell-specific and stage-specific gene transcription in transgenic mice\<br\>Biol Reprod (2009) 81, 571-579. PubMed  Europe PubMed DOI
  310. Yoshii,H., Kamiyama,H., Minematsu,K., Goto,K., Mizota,T., Oishi,K., Katunuma,N., Yamamoto,N. and Kubo,Y. \<br\>Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells\<br\>Virology (2009) 394, 227-234. PubMed  Europe PubMed DOI  I
  311. 2008
  312. Abboud-Jarrous,G., Atzmon,R., Peretz,T., Palermo,C., Gadea,B.B., Joyce,J.A. and Vlodavsky,I. \<br\>Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment\<br\>J Biol Chem (2008) 283, 18167-18176. PubMed  Europe PubMed DOI  PMC  EPMC
  313. Bosch,B.J., Bartelink,W. and Rottier,P.J. \<br\>Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide\<br\>J Virol (2008) 82, 8887-8890. PubMed  Europe PubMed DOI  PMC  EPMC
  314. Chowdhury,S.F., Joseph,L., Kumar,S., Tulsidas,S.R., Bhat,S., Ziomek,E., Menard,R., Sivaraman,J. and Purisima,E.O. \<br\>Exploring inhibitor binding at the S' subsites of cathepsin L\<br\>J Med Chem (2008) 51, 1361-1368. PubMed  Europe PubMed DOI  S  I
  315. Duncan,E.M., Muratore-Schroeder,T.L., Cook,R.G., Garcia,B.A., Shabanowitz,J., Hunt,D.F. and Allis,C.D. \<br\>Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation\<br\>Cell (2008) 135, 284-294. PubMed  Europe PubMed DOI  PMC  EPMC  P
  316. Fairhead,M., Johnson,K.A., Kowatz,T., McMahon,S.A., Carter,L.G., Oke,M., Liu,H., Naismith,J.H. and van der Walle,C.F. \<br\>Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras\<br\>Chem Commun (Camb) (2008) 2008, 1765-1767. PubMed  Europe PubMed DOI  S
  317. Fairhead,M. and van der Walle,C.F. \<br\>The heavy-light chain loop of human cathepsin-L modulates its activity and stability\<br\>Protein Pept Lett (2008) 15, 47-53. PubMed  Europe PubMed DOI
  318. Fairhead,M., Kelly,S.M. and van der Walle,C.F. \<br\>A heparin binding motif on the pro-domain of human procathepsin L mediates zymogen destabilization and activation\<br\>Biochem Biophys Res Commun (2008) 366, 862-867. PubMed  Europe PubMed DOI
  319. Funkelstein,L., Toneff,T., Hwang,S.R., Reinheckel,T., Peters,C. and Hook,V. \<br\>Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression\<br\>J Neurochem (2008) 106, 384-391. PubMed  Europe PubMed DOI  PMC  EPMC  K
  320. Funkelstein,L., Toneff,T., Mosier,C., Hwang,S.R., Beuschlein,F., Lichtenauer,U.D., Reinheckel,T., Peters,C. and Hook,V. \<br\>Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression\<br\>J Biol Chem (2008) 283, 35652-35659. PubMed  Europe PubMed DOI  PMC  EPMC  I
  321. Hook,V., Funkelstein,L., Lu,D., Bark,S., Wegrzyn,J. and Hwang,S.R. \<br\>Proteases for processing proneuropeptides into peptide neurotransmitters and hormones\<br\>Annu Rev Pharmacol Toxicol (2008) 48, 393-423. PubMed  Europe PubMed DOI  PMC  EPMC
  322. Jean,D., Rousselet,N. and Frade,R. \<br\>Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region\<br\>Biochem J (2008) 413, 125-134. PubMed  Europe PubMed DOI
  323. Myers,M.C., Shah,P.P., Diamond,S.L., Huryn,D.M. and Smith,A.B., III \<br\>Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor\<br\>Bioorg Med Chem Lett (2008) 18, 210-214. PubMed  Europe PubMed DOI  PMC  EPMC  I
  324. Myers,M.C., Shah,P.P., Beavers,M.P., Napper,A.D., Diamond,S.L., Smith,A.B., III and Huryn,D.M. \<br\>Design, synthesis, and evaluation of inhibitors of cathepsin L: exploiting a unique thiocarbazate chemotype\<br\>Bioorg Med Chem Lett (2008) 18, 3646-3651. PubMed  Europe PubMed DOI  PMC  EPMC  I
  325. Schaschke,N., Assfalg-Machleidt,I. and Machleidt,W. \<br\>Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions\<br\>Chembiochem (2008) 9, 1721-1724. PubMed  Europe PubMed DOI  I
  326. Shah,P.P., Myers,M.C., Beavers,M.P., Purvis,J.E., Jing,H., Grieser,H.J., Sharlow,E.R., Napper,A.D., Huryn,D.M., Cooperman,B.S., Smith,A.B., III and Diamond,S.L. \<br\>Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L\<br\>Mol Pharmacol (2008) 74, 34-41. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  327. Yadav,M.R., Shinde,A.K., Chouhan,B.S., Giridhar,R. and Menard,R. \<br\>Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors\<br\>J Enzyme Inhib Med Chem (2008) 23, 190-197. PubMed  Europe PubMed DOI  I
  328. Zhu,S., Wei,L., Yamasaki,K. and Gallo,R.L. \<br\>Activation of cathepsin L by the cathelin-like domain of protegrin-3\<br\>Mol Immunol (2008) 45, 2531-2536. PubMed  Europe PubMed DOI  PMC  EPMC
  329. 2007
  330. Boudreau,F., Lussier,C.R., Mongrain,S., Darsigny,M., Drouin,J.L., Doyon,G., Suh,E.R., Beaulieu,J.F., Rivard,N. and Perreault,N. \<br\>Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia\<br\>FASEB J (2007) 21, 3853-3865. PubMed  Europe PubMed DOI  K
  331. Burden,R.E., Snoddy,P., Jefferies,C.A., Walker,B. and Scott,C.J. \<br\>Inhibition of cathepsin L-like proteases by cathepsin V propeptide\<br\>Biol Chem (2007) 388, 541-545. PubMed  Europe PubMed DOI
  332. Charron,M., Chern,J.Y. and Wright,W.W. \<br\>The cathepsin L first intron stimulates gene expression in rat Sertoli cells\<br\>Biol Reprod (2007) 76, 813-824. PubMed  Europe PubMed DOI
  333. Goulet,B., Sansregret,L., Leduy,L., Bogyo,M., Weber,E., Chauhan,S.S. and Nepveu,A. \<br\>Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation\<br\>Mol Cancer Res (2007) 5, 899-907. PubMed  Europe PubMed DOI
  334. Hwang,S.R., Garza,C., Mosier,C., Toneff,T., Wunderlich,E., Goldsmith,P. and Hook,V. \<br\>Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion\<br\>J Biol Chem (2007) 282, 9556-9563. PubMed  Europe PubMed DOI
  335. Kramer,G., Paul,A., Kreusch,A., Schuler,S., Wiederanders,B. and Schilling,K. \<br\>Optimized folding and activation of recombinant procathepsin L and S produced in Escherichia coli\<br\>Protein Expr Purif (2007) 54, 147-156. PubMed  Europe PubMed DOI  E
  336. Mori,Y., Yamashita,T., Tanaka,Y., Tsuda,Y., Abe,T., Moriishi,K. and Matsuura,Y. \<br\>Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells\<br\>J Virol (2007) 81, 8477-8487. PubMed  Europe PubMed DOI  PMC  EPMC
  337. Ruettger,A. and Wiederanders,B. \<br\>Microplate assay for cathepsin detection in viable cells using derivatives of 4-methoxy-beta-naphthylamide\<br\>Curr Protoc Protein Sci (2007) Unit 21.21, Unit 21.21. PubMed  Europe PubMed DOI  A
  338. Sever,S., Altintas,M.M., Nankoe,S.R., Moller,C.C., Ko,D., Wei,C., Henderson,J., del Re,E.C., Hsing,L., Erickson,A., Cohen,C.D., Kretzler,M., Kerjaschki,D., Rudensky,A., Nikolic,B. and Reiser,J. \<br\>Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease\<br\>J Clin Invest (2007) 117, 2095-2104. PubMed  Europe PubMed DOI  PMC  EPMC
  339. Spira,D., Stypmann,J., Tobin,D.J., Petermann,I., Mayer,C., Hagemann,S., Vasiljeva,O., Gunther,T., Schule,R., Peters,C. and Reinheckel,T. \<br\>Cell type-specific functions of the lysosomal protease cathepsin L in the heart\<br\>J Biol Chem (2007) 282, 37045-37052. PubMed  Europe PubMed DOI
  340. Stahl,S., Reinders,Y., Asan,E., Mothes,W., Conzelmann,E., Sickmann,A. and Felbor,U. \<br\>Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes\<br\>Biochim Biophys Acta (2007) 1774, 1237-1246. PubMed  Europe PubMed DOI  K
  341. Tingaud-Sequeira,A. and Cerda,J. \<br\>Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme\<br\>Gene (2007) 386, 98-106. PubMed  Europe PubMed DOI
  342. Walz,M., Kellermann,S., Bylaite,M., Andree,B., Ruther,U., Paus,R., Kloepper,J.E., Reifenberger,J. and Ruzicka,T. \<br\>Expression of the human cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis\<br\>Exp Dermatol (2007) 16, 715-723. PubMed  Europe PubMed DOI
  343. Yang,M., Zhang,Y., Pan,J., Sun,J., Liu,J., Libby,P., Sukhova,G.K., Doria,A., Katunuma,N., Peroni,O.D., Guerre-Millo,M., Kahn,B.B., Clement,K. and Shi,G.P. \<br\>Cathepsin L activity controls adipogenesis and glucose tolerance\<br\>Nat Cell Biol (2007) 9, 970-977. PubMed  Europe PubMed DOI  K  I
  344. Yang,Z. and Cox,J.L. \<br\>Cathepsin L increases invasion and migration of B16 melanoma\<br\>Cancer Cell Int (2007) 7, 8. PubMed  Europe PubMed DOI  PMC  EPMC
  345. 2006
  346. [YEAR:15-1-2006]Benavides,F., Perez,C., Blando,J., Guenet,J.L. and Conti,C.J. \<br\>The radiation-induced nackt (nkt) allele is a loss-of-function mutation of the mouse cathepsin L gene\<br\>J Immunol (15-1-2006) 176, 702-703. PubMed  Europe PubMed  M
  347. Bulynko,Y.A., Hsing,L.C., Mason,R.W., Tremethick,D.J. and Grigoryev,S.A. \<br\>Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin\<br\>Mol Cell Biol (2006) 26, 4172-4184. PubMed  Europe PubMed DOI  PMC  EPMC
  348. Caserman,S., Kenig,S., Sloane,B.F. and Lah,T.T. \<br\>Cathepsin L splice variants in human breast cell lines\<br\>Biol Chem (2006) 387, 629-634. PubMed  Europe PubMed DOI  R
  349. [YEAR:24-3-2006]Cheng,T., Hitomi,K., van Vlijmen-Willems,I.M., de Jongh,G.J., Yamamoto,K., Nishi,K., Watts,C., Reinheckel,T., Schalkwijk,J. and Zeeuwen,P.L. \<br\>Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification\<br\>J Biol Chem (24-3-2006) 281, 15893-15899. PubMed  Europe PubMed DOI
  350. [YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S. \<br\>Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities\<br\>J Biol Chem (6-3-2006) 281, 12824-12832. PubMed  Europe PubMed DOI  P
  351. Goulet,B., Truscott,M. and Nepveu,A. \<br\>A novel proteolytically processed CDP/Cux isoform of 90 kDa is generated by cathepsin L\<br\>Biol Chem (2006) 387, 1285-1293. PubMed  Europe PubMed DOI
  352. Hashimoto,Y., Kondo,C., Kojima,T., Nagata,H., Moriyama,A., Hayakawa,T. and Katunuma,N. \<br\>Significance of 32-kDa cathepsin L secreted from cancer cells\<br\>Cancer Biother Radiopharm (2006) 21, 217-224. PubMed  Europe PubMed DOI
  353. [YEAR:31-10-2006]Jean,D., Rousselet,N. and Frade,R. \<br\>Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms\<br\>Oncogene (31-10-2006) 25, 1474-1484. PubMed  Europe PubMed DOI
  354. Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D. \<br\>Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins\<br\>Biol Chem (2006) 387, 1295-1303. PubMed  Europe PubMed DOI  P
  355. [YEAR:13-12-2006]Liu,H., Yin,L., Zhang,N., Li,S. and Ma,C. \<br\>Purification and characterization of cathepsin L from the muscle of silver carp (Hypophthalmichthys molitrix)\<br\>J Agric Food Chem (13-12-2006) 54, 9584-9591. PubMed  Europe PubMed DOI
  356. [YEAR:24-6-2006]Liu,J., Sukhova,G.K., Yang,J.T., Sun,J., Ma,L., Ren,A., Xu,W.H., Fu,H., Dolganov,G.M., Hu,C., Libby,P. and Shi,G.P. \<br\>Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells\<br\>Atherosclerosis (24-6-2006) 184, 302-311. PubMed  Europe PubMed DOI
  357. Petermann,I., Mayer,C., Stypmann,J., Biniossek,M.L., Tobin,D.J., Engelen,M.A., Dandekar,T., Grune,T., Schild,L., Peters,C. and Reinheckel,T. \<br\>Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice\<br\>FASEB J (2006) 20, 1266-1268. PubMed  Europe PubMed DOI  K
  358. Ruttger,A., Mollenhauer,J., Loser,R., Gutschow,M. and Wiederanders,B. \<br\>Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide\<br\>Biotechniques (2006) 41, 469-473. PubMed  Europe PubMed DOI  A
  359. Sevenich,L., Pennacchio,L.A., Peters,C. and Reinheckel,T. \<br\>Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice\<br\>Biol Chem (2006) 387, 885-891. PubMed  Europe PubMed DOI  K
  360. [YEAR:25-8-2006]Vicik,R., Busemann,M., Gelhaus,C., Stiefl,N., Scheiber,J., Schmitz,W., Schulz,F., Mladenovic,M., Engels,B., Leippe,M., Baumann,K. and Schirmeister,T. \<br\>Aziridide-based inhibitors of cathepsin L: synthesis, inhibition activity, and docking studies\<br\>ChemMedChem (25-8-2006) 1, 1126-1141. PubMed  Europe PubMed DOI  I
  361. Zajc,I., Hreljac,I. and Lah,T. \<br\>Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics\<br\>Anticancer Res (2006) 26, 3357-3364. PubMed  Europe PubMed
  362. 2005
  363. [YEAR:10-2-2005]Gordon,P.V., Paxton,J.B., Kuemmerle,J.F. and Fox,N.S. \<br\>A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells\<br\>Am J Physiol Gastrointest Liver Physiol (10-2-2005) 289, G79-G87. PubMed  Europe PubMed DOI
  364. Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y. \<br\>Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)\<br\>Am J Pathol (2005) 167, 1713-1728. PubMed  Europe PubMed DOI  PMC  EPMC  K
  365. [YEAR:1-10-2005]Maehr,R., Mintern,J.D., Herman,A.E., Lennon-Dumenil,A.M., Mathis,D., Benoist,C. and Ploegh,H.L. \<br\>Cathepsin L is essential for onset of autoimmune diabetes in NOD mice\<br\>J Clin Invest (1-10-2005) 115, 2934-2943. PubMed  Europe PubMed DOI  PMC  EPMC
  366. [YEAR:3-11-2005]Marquis,R.W., James,I., Zeng,J., Trout,R.E., Thompson,S., Rahman,A., Yamashita,D.S., Xie,R., Ru,Y., Gress,C.J., Blake,S., Lark,M.A., Hwang,S.M., Tomaszek,T., Offen,P., Head,M.S., Cummings,M.D. and Veber,D.F. \<br\>Azepanone-based inhibitors of human cathepsin L\<br\>J Med Chem (3-11-2005) 48, 6870-6878. PubMed  Europe PubMed DOI  I
  367. Nishinaka,T., Song,J., Lum,K. and Chiu,R. \<br\>Molecular cloning of cDNA for SPase, a monkey cathepsin L orthologue\<br\>DNA Seq (2005) 16, 147-150. PubMed  Europe PubMed DOI
  368. Pager,C.T. and Dutch,R.E. \<br\>Cathepsin L is involved in proteolytic processing of the Hendra virus fusion protein\<br\>J Virol (2005) 79, 12714-12720. PubMed  Europe PubMed DOI  PMC  EPMC
  369. Puzer,L., Vercesi,J., Alves,M.F., Barros,N.M., Araujo,M.S., Aparecida Juliano,M., Reis,M.L., Juliano,L. and Carmona,A.K. \<br\>A possible alternative mechanism of kinin generation in vivo by cathepsin L\<br\>Biol Chem (2005) 386, 699-704. PubMed  Europe PubMed DOI
  370. [YEAR:1-8-2005]Reinheckel,T., Hagemann,S., Dollwet-Mack,S., Martinez,E., Lohmuller,T., Zlatkovic,G., Tobin,D.J., Maas-Szabowski,N. and Peters,C. \<br\>The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling\<br\>J Cell Sci (1-8-2005) 118, 3387-3395. PubMed  Europe PubMed DOI
  371. Rocken,C., Menard,R., Buhling,F., Vockler,S., Raynes,J., Stix,B., Kruger,S., Roessner,A. and Kahne,T. \<br\>Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation\<br\>Ann Rheum Dis (2005) 64, 808-815. PubMed  Europe PubMed DOI  PMC  EPMC
  372. [YEAR:4-8-2005]Simmons,G., Gosalia,D.N., Rennekamp,A.J., Reeves,J.D., Diamond,S.L. and Bates,P. \<br\>Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry\<br\>Proc Natl Acad Sci U S A (4-8-2005) 102, 11876-11881. PubMed  Europe PubMed DOI  PMC  EPMC
  373. Urbich,C., Heeschen,C., Aicher,A., Sasaki,K., Bruhl,T., Farhadi,M.R., Vajkoczy,P., Hofmann,W.K., Peters,C., Pennacchio,L.A., Abolmaali,N.D., Chavakis,E., Reinheckel,T., Zeiher,A.M. and Dimmeler,S. \<br\>Cathepsin L is required for endothelial progenitor cell-induced neovascularization\<br\>Nat Med (2005) 11, 206-213. PubMed  Europe PubMed DOI
  374. 2004
  375. [YEAR:1-11-2004]Collette,J., Ulku,A.S., Der,C.J., Jones,A. and Erickson,A.H. \<br\>Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells\<br\>Int J Cancer (1-11-2004) 112, 190-199. PubMed  Europe PubMed DOI
  376. Collette,J., Bocock,J.P., Ahn,K., Chapman,R.L., Godbold,G., Yeyeodu,S. and Erickson,A.H. \<br\>Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L\<br\>Int Rev Cytol (2004) 241, 1-51. PubMed  Europe PubMed DOI
  377. [YEAR:16-8-2004]Goulet,B. and Nepveu,A. \<br\>Complete and limited proteolysis in cell cycle progression\<br\>Cell Cycle (16-8-2004) 3, 986-989. PubMed  Europe PubMed
  378. [YEAR:23-4-2004]Goulet,B., Baruch,A., Moon,N.S., Poirier,M., Sansregret,L.L., Erickson,A., Bogyo,M. and Nepveu,A. \<br\>A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor\<br\>Mol Cell (23-4-2004) 14, 207-219. PubMed  Europe PubMed DOI
  379. Hook,V., Yasothornsrikul,S., Greenbaum,D., Medzihradszky,K.F., Troutner,K., Toneff,T., Bundey,R., Logrinova,A., Reinheckel,T., Peters,C. and Bogyo,M. \<br\>Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones\<br\>Biol Chem (2004) 385, 473-480. PubMed  Europe PubMed DOI
  380. Hook,V.Y.H. \<br\>Prohormone thiol protease\<br\>[ISSN:0-12-079610-4] (2004) 2, 1408-1413.  V
  381. Hu,K.J. and Leung,P.C. \<br\>Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte\<br\>Comp Biochem Physiol B Biochem Mol Biol (2004) 137, 21-33. PubMed  Europe PubMed DOI
  382. Kirschke,H. \<br\>Cathepsin L\<br\>[ISSN:0-12-079610-4] (2004) 2, 1097-1102.  V
  383. Onishi,K., Li,Y., Ishii,K., Hisaeda,H., Tang,L., Duan,X., Dainichi,T., Maekawa,Y., Katunuma,N. and Himeno,K. \<br\>Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection\<br\>Microbes Infect (2004) 6, 468-474. PubMed  Europe PubMed DOI  I
  384. [YEAR:15-10-2004]Puzer,L., Cotrin,S.S., Alves,M.F., Egborge,T., Araujo,M.S., Juliano,M.A., Juliano,L., Bromme,D. and Carmona,A.K. \<br\>Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L\<br\>Arch Biochem Biophys (15-10-2004) 430, 274-283. PubMed  Europe PubMed DOI
  385. [YEAR:15-12-2004]Ravanko,K., Jarvinen,K., Helin,J., Kalkkinen,N. and Holtta,E. \<br\>Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts\<br\>Cancer Res (15-12-2004) 64, 8831-8838. PubMed  Europe PubMed DOI
  386. [YEAR:1-1-2004]Rousselet,N., Mills,L., Jean,D., Tellez,C., Bar-Eli,M. and Frade,R. \<br\>Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment\<br\>Cancer Res (1-1-2004) 64, 146-151. PubMed  Europe PubMed DOI
  387. Schedel,J., Seemayer,C.A., Pap,T., Neidhart,M., Kuchen,S., Michel,B.A., Gay,R.E., Muller-Ladner,U., Gay,S. and Zacharias,W. \<br\>Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis\<br\>Gene Ther (2004) 11, 1040-1047. PubMed  Europe PubMed DOI
  388. Sentandreu,M.A., Aubry,L. and Ouali,A. \<br\>A rapid purification procedure for cathepsin L from bovine species and production of specific antibodies\<br\>J Sci Food Agric (2004) 84, 2052-2060.
  389. [YEAR:22-11-2004]Soukenik,M., Diehl,A., Leidert,M., Sievert,V., Bussow,K., Leitner,D., Labudde,D., Ball,L.J., Lechner,A., Nagler,D.K. and Oschkinat,H. \<br\>The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L\<br\>FEBS Lett (22-11-2004) 576, 358-362. PubMed  Europe PubMed DOI
  390. [YEAR:16-10-2004]Sriraman,V. and Richards,J.S. \<br\>Cathepsin L gene expression and promoter activation in rodent granulosa cells\<br\>Endocrinology (16-10-2004) 145, 582-591. PubMed  Europe PubMed DOI
  391. Wille,A., Gerber,A., Heimburg,A., Reisenauer,A., Peters,C., Saftig,P., Reinheckel,T., Welte,T. and Buhling,F. \<br\>Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells\<br\>Biol Chem (2004) 385, 665-670. PubMed  Europe PubMed DOI
  392. 2003
  393. [YEAR:20-1-2003]Beers,C., Honey,K., Fink,S., Forbush,K. and Rudensky,A. \<br\>Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages\<br\>J Exp Med (20-1-2003) 197, 169-179. PubMed  Europe PubMed DOI  PMC  EPMC
  394. Charron,M., Folmer,J.S. and Wright,W.W. \<br\>A 3-kilobase region derived from the rat cathepsin L gene directs in vivo expression of a reporter gene in sertoli cells in a manner comparable to that of the endogenous gene\<br\>Biol Reprod (2003) 68, 1641-1648. PubMed  Europe PubMed DOI
  395. Charron,M., DeCerbo,J.N. and Wright,W.W. \<br\>A GC-box within the proximal promoter region of the rat cathepsin L gene activates transcription in Sertoli cells of sexually mature rats\<br\>Biol Reprod (2003) 68, 1649-1656. PubMed  Europe PubMed DOI
  396. Desmazes,C., Galineau,L., Gauthier,F., Bromme,D. and Lalmanach,G. \<br\>Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L\<br\>Eur J Biochem (2003) 270, 171-178. PubMed  Europe PubMed DOI
  397. Levicar,N., Dewey,R.A., Daley,E., Bates,T.E., Davies,D., Kos,J., Pilkington,G.J. and Lah,T.T. \<br\>Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis\<br\>Cancer Gene Ther (2003) 10, 141-151. PubMed  Europe PubMed DOI  K
  398. [YEAR:26-6-2003]Ohashi,K., Naruto,M., Nakaki,T. and Sano,E. \<br\>Identification of interleukin-8 converting enzyme as cathepsin L\<br\>Biochim Biophys Acta (26-6-2003) 1649, 30-39. PubMed  Europe PubMed DOI
  399. [YEAR:4-12-2003]Seth,P., Mahajan,V.S. and Chauhan,S.S. \<br\>Transcription of human cathepsin L mRNA species hCATL B from a novel alternative promoter in the first intron of its gene\<br\>Gene (4-12-2003) 321, 83-91. PubMed  Europe PubMed DOI
  400. [YEAR:24-6-2003]Welss,T., Sun,J., Irving,J.A., Blum,R., Smith,A.I., Whisstock,J.C., Pike,R.N., von Mikecz,A., Ruzicka,T., Bird,P.I. and Abts,H.F. \<br\>Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis\<br\>Biochemistry (24-6-2003) 42, 7381-7389. PubMed  Europe PubMed DOI
  401. Wright,W.W., Smith,L., Kerr,C. and Charron,M. \<br\>Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis\<br\>Biol Reprod (2003) 68, 680-687. PubMed  Europe PubMed DOI
  402. [YEAR:5-8-2003]Yasothornsrikul,S., Greenbaum,D., Medzihradszky,K.F., Toneff,T., Bundey,R., Miller,R., Schilling,B., Petermann,I., Dehnert,J., Logvinova,A., Goldsmith,P., Neveu,J.M., Lane,W.S., Gibson,B., Reinheckel,T., Peters,C., Bogyo,M. and Hook,V. \<br\>Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter\<br\>Proc Natl Acad Sci U S A (5-8-2003) 100, 9590-9595. PubMed  Europe PubMed DOI  PMC  EPMC
  403. 2002
  404. [YEAR:26-6-2002]Arora,S. and Chauhan,S.S. \<br\>Identification and characterization of a novel human cathepsin L splice variant\<br\>Gene (26-6-2002) 293, 123-131. PubMed  Europe PubMed DOI  R
  405. Benavides,F., Starost,M.F., Flores,M., Gimenez-Conti,I.B., Guenet,J.L. and Conti,C.J. \<br\>Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation\<br\>Am J Pathol (2002) 161, 693-703. PubMed  Europe PubMed DOI  PMC  EPMC  K  M
  406. [YEAR:21-11-2002]Chowdhury,S.F., Sivaraman,J., Wang,J., Devanathan,G., Lachance,P., Qi,H., Menard,R., Lefebvre,J., Konishi,Y., Cygler,M., Sulea,T. and Purisima,E.O. \<br\>Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides\<br\>J Med Chem (21-11-2002) 45, 5321-5329. PubMed  Europe PubMed DOI  S  I
  407. [YEAR:5-7-2002]Ebert,D.H., Deussing,J., Peters,C. and Dermody,T.S. \<br\>Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells\<br\>J Biol Chem (5-7-2002) 277, 24609-24617. PubMed  Europe PubMed DOI
  408. [YEAR:11-6-2002]Felbor,U., Kessler,B., Mothes,W., Goebel,H.H., Ploegh,H.L., Bronson,R.T. and Olsen,B.R. \<br\>Neuronal loss and brain atrophy in mice lacking cathepsins B and L\<br\>Proc Natl Acad Sci U S A (11-6-2002) 99, 7883-7888. PubMed  Europe PubMed DOI  PMC  EPMC  K
  409. [YEAR:4-11-2002]Fiebiger,E., Maehr,R., Villadangos,J., Weber,E., Erickson,A., Bikoff,E., Ploegh,H.L. and Lennon-Dumenil,A.M. \<br\>Invariant chain controls the activity of extracellular cathepsin L\<br\>J Exp Med (4-11-2002) 196, 1263-1269. PubMed  Europe PubMed DOI  PMC  EPMC
  410. [YEAR:1-10-2002]Guillaume-Rousselet,N., Jean,D. and Frade,R. \<br\>Cloning and characterization of anti-cathepsin L single chain variable fragment whose expression inhibits procathepsin L secretion in human melanoma cells\<br\>Biochem J (1-10-2002) 367, 219-227. PubMed  Europe PubMed DOI  PMC  EPMC
  411. [YEAR:20-5-2002]Honey,K., Nakagawa,T., Peters,C. and Rudensky,A. \<br\>Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands\<br\>J Exp Med (20-5-2002) 195, 1349-1358. PubMed  Europe PubMed DOI  PMC  EPMC
  412. [YEAR:1-1-2002]Jean,D., Guillaume,N. and Frade,R. \<br\>Characterization of human cathepsin L promoter and identification of binding sites for NF-Y, Sp1 and Sp3 that are essential for its activity\<br\>Biochem J (1-1-2002) 361, 173-184. PubMed  Europe PubMed DOI  PMC  EPMC
  413. Nishimura,F., Naruishi,H., Naruishi,K., Yamada,T., Sasaki,J., Peters,C., Uchiyama,Y. and Murayama,Y. \<br\>Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice\<br\>Am J Pathol (2002) 161, 2047-2052. PubMed  Europe PubMed DOI  PMC  EPMC
  414. Siavash,H., Lopes,M., Norris,K., Hebert,C., Nikitakis,N. and Sauk,J.J. \<br\>Inhibition of cysteine proteinases by autolytic digestion is mediated by CBP2/Hsp47\<br\>Connect Tissue Res (2002) 43, 589-594. PubMed  Europe PubMed
  415. [YEAR:30-4-2002]Stypmann,J., Glaser,K., Roth,W., Tobin,D.J., Petermann,I., Matthias,R., Monnig,G., Haverkamp,W., Breithardt,G., Schmahl,W., Peters,C. and Reinheckel,T. \<br\>Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L\<br\>Proc Natl Acad Sci U S A (30-4-2002) 99, 6234-6239. PubMed  Europe PubMed DOI  PMC  EPMC  K
  416. Tobin,D.J., Foitzik,K., Reinheckel,T., Mecklenburg,L., Botchkarev,V.A., Peters,C. and Paus,R. \<br\>The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling\<br\>Am J Pathol (2002) 160, 1807-1821. PubMed  Europe PubMed DOI  PMC  EPMC
  417. [YEAR:1-11-2002]Warner,J.B., Thalhauser,C., Tao,K. and Sahagian,G.G. \<br\>Role of N-linked oligosaccharide flexibility in mannose phosphorylation of lysosomal enzyme cathepsin L\<br\>J Biol Chem (1-11-2002) 277, 41897-41905. PubMed  Europe PubMed DOI
  418. 2001
  419. Abudula,A., Rommerskirch,W., Weber,E., Gunther,D. and Wiederanders,B. \<br\>Splice variants of human cathepsin L mRNA show different expression rates\<br\>Biol Chem (2001) 382, 1583-1591. PubMed  Europe PubMed DOI  R
  420. [YEAR:5-9-2001]Bakhshi,R., Goel,A., Seth,P., Chhikara,P. and Chauhan,S.S. \<br\>Cloning and characterization of human cathepsin L promoter\<br\>Gene (5-9-2001) 275, 93-101. PubMed  Europe PubMed DOI
  421. Benavides,F., Venables,A., Poetschke Klug,H., Glasscock,E., Rudensky,A., Gomez,M., Martin Palenzuela,N., Guenet,J.L., Richie,E.R. and Conti,C.J. \<br\>The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (Ctsl) gene\<br\>Immunogenetics (2001) 53, 233-242. PubMed  Europe PubMed DOI
  422. Harrison,M.T. and McCoy,K.L. \<br\>Immunosuppression by arsenic: a comparison of cathepsin L inhibition and apoptosis\<br\>Int Immunopharmacol (2001) 1, 647-656. PubMed  Europe PubMed DOI
  423. [YEAR:22-6-2001]Honey,K., Duff,M., Beers,C., Brissette,W.H., Elliott,E.A., Peters,C., Maric,M., Cresswell,P. and Rudensky,A. \<br\>Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes\<br\>J Biol Chem (22-6-2001) 276, 22573-22578. PubMed  Europe PubMed DOI  K
  424. [YEAR:13-4-2001]James,I.E., Marquis,R.W., Blake,S.M., Hwang,S.M., Gress,C.J., Ru,Y., Zembryki,D., Yamashita,D.S., McQueney,M.S., Tomaszek,T.A., Oh,H.J., Gowen,M., Veber,D.F. and Lark,M.W. \<br\>Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro\<br\>J Biol Chem (13-4-2001) 276, 11507-11511. PubMed  Europe PubMed DOI  I
  425. Krueger,S., Kellner,U., Buehling,F. and Roessner,A. \<br\>Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype\<br\>Cancer Gene Ther (2001) 8, 522-528. PubMed  Europe PubMed DOI
  426. [YEAR:1-8-2001]Lennon-Dumenil,A.M., Roberts,R.A., Valentijn,K., Driessen,C., Overkleeft,H.S., Erickson,A., Peters,P.J., Bikoff,E., Ploegh,H.L. and Bryant,P.W. \<br\>The p41 isoform of invariant chain is a chaperone for cathepsin L\<br\>EMBO J (1-8-2001) 20, 4055-4064. PubMed  Europe PubMed DOI  PMC  EPMC
  427. [YEAR:1-6-2001]Melo,R.L., Alves,L.C., Del Nery,E., Juliano,L. and Juliano,M.A. \<br\>Synthesis and hydrolysis by cysteine and serine proteases of short internally quenched fluorogenic peptides\<br\>Anal Biochem (1-6-2001) 293, 71-77. PubMed  Europe PubMed DOI
  428. Reinheckel,T., Deussing,J., Roth,W. and Peters,C. \<br\>Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L\<br\>Biol Chem (2001) 382, 735-741. PubMed  Europe PubMed DOI  K
  429. Visessanguan,W., Menino,A.R., Kim,S.M. and An,H. \<br\>Cathepsin L: A predominant heat-activated proteinase in arrowtooth flounder muscle\<br\>J Agric Food Chem (2001) 49, 2633-2640. PubMed  Europe PubMed DOI
  430. 2000
  431. [YEAR:15-3-2000]Felbor,U., Dreier,L., Bryant,R.A., Ploegh,H.L., Olsen,B.R. and Mothes,W. \<br\>Secreted cathepsin L generates endostatin from collagen XVIII\<br\>EMBO J (15-3-2000) 19, 1187-1194. PubMed  Europe PubMed DOI  PMC  EPMC
  432. Guay,J., Falgueyret,J.P., Ducret,A., Percival,M.D. and Mancini,J.A. \<br\>Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides\<br\>Eur J Biochem (2000) 267, 6311-6318. PubMed  Europe PubMed DOI
  433. Jacobsen,W., Christians,U. and Benet,L.Z. \<br\>In vitro evaluation of the disposition of a novel cysteine protease inhibitor\<br\>Drug Metab Dispos (2000) 28, 1343-1351. PubMed  Europe PubMed  I
  434. Kirschke,H., Eerola,R., Hopsu-Havu,V.K., Bromme,D. and Vuorio,E. \<br\>Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells\<br\>Eur J Cancer (2000) 36, 787-795. PubMed  Europe PubMed DOI
  435. [YEAR:15-7-2000]Krupa,J.C. and Mort,J.S. \<br\>Optimization of detergents for the assay of cathepsins B, L, S, and K\<br\>Anal Biochem (15-7-2000) 283, 99-103. PubMed  Europe PubMed DOI  A
  436. [YEAR:7-8-2000]Lynas,J.F., Hawthorne,S.J. and Walker,B. \<br\>Development of peptidyl alpha-keto-beta-aldehydes as new inhibitors of cathepsin L - comparisons of potency and selectivity profiles with cathepsin B\<br\>Bioorg Med Chem Lett (7-8-2000) 10, 1771-1773. PubMed  Europe PubMed DOI  I
  437. [YEAR:1-4-2000]Portaro,F.C., Santos,A.B., Cezari,M.H., Juliano,M.A., Juliano,L. and Carmona,E. \<br\>Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates\<br\>Biochem J (1-4-2000) 347, 123-129. PubMed  Europe PubMed DOI  PMC  EPMC
  438. Roth,W., Deussing,J., Botchkarev,V.A., Pauly-Evers,M., Saftig,P., Hafner,A., Schmidt,P., Schmahl,W., Scherer,J., Anton-Lamprecht,I., von Figura,K., Paus,R. and Peters,C. \<br\>Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling\<br\>FASEB J (2000) 14, 2075-2086. PubMed  Europe PubMed DOI  K  M
  439. 1999
  440. Ando,R., Sakaki,T., Morinaka,Y., Takahashi,C., Tamao,Y., Yoshii,N., Katayama,S., Saito,K.I., Tokuyama,H., Isaka,M. and Nakamura,E. \<br\>Cyclopropenone-containing cysteine proteinase inhibitors. Synthesis and enzyme inhibitory activities\<br\>Bioorg Med Chem (1999) 7, 571-579. PubMed  Europe PubMed  I
  441. Baer,G.S., Ebert,D.H., Chung,C.J., Erickson,A.H. and Dermody,T.S. \<br\>Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly\<br\>J Virol (1999) 73, 9532-9543. PubMed  Europe PubMed  PMC  EPMC
  442. [YEAR:15-2-1999]Guncar,G., Pungercic,G., Klemencic,I., Turk,V. and Turk,D. \<br\>Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S\<br\>EMBO J (15-2-1999) 18, 793-803. PubMed  Europe PubMed DOI  PMC  EPMC  S
  443. Hook,V.Y., Tezapsidis,N., Hwang,S.R., Sei,C., Byrne,M. and Yasothornsrikul,S. \<br\>alpha1-Antichymotrypsin-like proteins I and II purified from bovine adrenal medulla are enriched in chromaffin granules and inhibit the proenkephalin processing enzyme "prohormone thiol protease"\<br\>J Neurochem (1999) 73, 59-69. PubMed  Europe PubMed DOI
  444. [YEAR:10-9-1999]Katunuma,N., Murata,E., Kakegawa,H., Matsui,A., Tsuzuki,H., Tsuge,H., Turk,D., Turk,V., Fukushima,M., Tada,Y. and Asao,T. \<br\>Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo\<br\>FEBS Lett (10-9-1999) 458, 6-10. PubMed  Europe PubMed DOI  I
  445. Matsumoto,K., Mizoue,K., Kitamura,K., Tse,W.C., Huber,C.P. and Ishida,T. \<br\>Structural basis of inhibition of cysteine proteases by E-64 and its derivatives\<br\>Biopolymers (1999) 51, 99-107. PubMed  Europe PubMed DOI  I
  446. Ogino,T., Kaji,T., Kawabata,M., Satoh,K., Tomoo,K., Ishida,T., Yamazaki,H., Ishidoh,K. and Kominami,E. \<br\>Function of the propeptide region in recombinant expression of active procathepsin L in Escherichia coli\<br\>J Biochem (1999) 126, 78-83. PubMed  Europe PubMed  E
  447. [YEAR:16-7-1999]Popovic,T., Cimerman,N., Dolenc,I., Ritonja,A. and Brzin,J. \<br\>Cathepsin L is capable of truncating cystatin C of 11 N-terminal amino acids\<br\>FEBS Lett (16-7-1999) 455, 92-96. PubMed  Europe PubMed DOI
  448. Werle,B., Staib,A., Julke,B., Ebert,W., Zladoidsky,P., Sekirnik,A., Kos,J. and Spiess,E. \<br\>Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extracts\<br\>Biol Chem (1999) 380, 1109-1116. PubMed  Europe PubMed DOI  A
  449. [YEAR:8-6-1999]Yasothornsrikul,S., Aaron,W., Toneff,T. and Hook,V.Y. \<br\>Evidence for the proenkephalin processing enzyme prohormone thiol protease (PTP) as a multicatalytic cysteine protease complex: activation by glutathione localized to secretory vesicles\<br\>Biochemistry (8-6-1999) 38, 7421-7430. PubMed  Europe PubMed DOI
  450. 1998
  451. [YEAR:18-9-1998]Le Boulay,C., Sellos,D. and Van Wormhoudt,A. \<br\>Cathepsin L gene organization in crustaceans\<br\>Gene (18-9-1998) 218, 77-84. PubMed  Europe PubMed DOI
  452. 1997
  453. Dalton,J.P., Clough,K.A., Jones,M.K. and Brindley,P.J. \<br\>The cysteine proteinases of Schistosoma mansoni cercariae\<br\>Parasitology (1997) 114, 105-112. PubMed  Europe PubMed DOI
  454. Fujishima,A., Imai,Y., Nomura,T., Fujisawa,Y., Yamamoto,Y. and Sugawara,T. \<br\>The crystal structure of human cathepsin L complexed with E-64\<br\>FEBS Lett (1997) 407, 47-50. PubMed  Europe PubMed DOI  S  I
  455. [YEAR:18-9-1997]Ishidoh,K., Taniguchi,S. and Kominami,E. \<br\>Egr family member proteins are involved in the activation of the cathepsin L gene in v-src-transformed cells\<br\>Biochem Biophys Res Commun (18-9-1997) 238, 665-669. PubMed  Europe PubMed DOI
  456. Matsumoto,I., Emori,Y., Abe,K. and Arai,S. \<br\>Characterization of a gene family encoding cysteine proteinases of Sitophilus zeamais (maize weevil), and analysis of the protein distribution in various tissues including alimentary tract and germ cells\<br\>J Biochem (1997) 121, 464-476. PubMed  Europe PubMed
  457. 1996
  458. Carmona,E., Dufour,E., Plouffe,C., Takebe,S., Mason,P., Mort,J.S. and Menard,R. \<br\>Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteases\<br\>Biochemistry (1996) 35, 8149-8157. PubMed  Europe PubMed DOI
  459. Coulombe,R., Li,Y., Takebe,S., Menard,R., Mason,P., Mort,J.S. and Cygler,M. \<br\>Crystallization and preliminary X-ray diffraction studies of human procathepsin L\<br\>Proteins (1996) 25, 398-400. PubMed  Europe PubMed DOI  S
  460. Coulombe,R., Grochulski,P., Sivaraman,J., Menard,R., Mort,J.S. and Cygler,M. \<br\>Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment\<br\>EMBO J (1996) 15, 5492-5503. PubMed  Europe PubMed  PMC  EPMC  E  S
  461. Dalton,J.P., McGonigle,S., Rolph,T.P. and Andrews,S.J. \<br\>Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin\<br\>Infect Immun (1996) 64, 5066-5074. PubMed  Europe PubMed  PMC  EPMC
  462. Dalton,J.P., Clough,K.A., Jones,M.K. and Brindley,P.J. \<br\>Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni\<br\>Infect Immun (1996) 64, 1328-1334. PubMed  Europe PubMed  PMC  EPMC
  463. Dehrmann,F.M., Elliott,E. and Dennison,C. \<br\>Reductive activation markedly increases the stability of cathepsins B and L to extracellular ionic conditions\<br\>Biol Chem Hoppe Seyler (1996) 377, 391-394. PubMed  Europe PubMed
  464. [YEAR:7-10-1996]Rescheleit,D.K., Rommerskirch,W.J. and Wiederanders,B. \<br\>Sequence analysis and distribution of two new human cathepsin L splice variants\<br\>FEBS Lett (7-10-1996) 394, 345-348. PubMed  Europe PubMed DOI  R
  465. Ritonja,A., Coetzer,T.H., Pike,R.N. and Dennison,C. \<br\>The amino acid sequences, structure comparisons and inhibition kinetics of sheep cathepsin L and sheep stefin B\<br\>Comp Biochem Physiol B Biochem Mol Biol (1996) 114, 193-198. PubMed  Europe PubMed DOI
  466. Volkel,H., Kurz,U., Linder,J., Klumpp,S., Gnau,V., Jung,G. and Schultz,J.E. \<br\>Cathepsin L is an intracellular and extracellular protease in Paramecium tetraurelia. Purification, cloning, sequencing and specific inhibition by its expressed propeptide\<br\>Eur J Biochem (1996) 238, 198-206. PubMed  Europe PubMed
  467. 1995
  468. Dolinar,M., Maganja,D.B. and Turk,V. \<br\>Expression of full-length human procathepsin L cDNA in Escherichia coli and refolding of the expression product\<br\>Biol Chem Hoppe Seyler (1995) 376, 385-388. PubMed  Europe PubMed  E
  469. Kawada,A., Hara,K., Hiruma,M., Noguchi,H. and Ishibashi,A. \<br\>Rat epidermal cathepsin L-like proteinase: Purification and some hydrolytic properties toward filaggrin and synthetic substrates\<br\>J Biochem (1995) 118, 332-337. PubMed  Europe PubMed
  470. [YEAR:4-8-1995]Martichonok,V., Plouffe,C., Storer,A.C., Menard,R. and Jones,J.B. \<br\>Aziridine analogs of [[trans-(epoxysuccinyl)-L-leucyl]amino]-4-guanidinobutane (E-64) as inhibitors of cysteine proteases\<br\>J Med Chem (4-8-1995) 38, 3078-3085. PubMed  Europe PubMed  I
  471. McDonald,J.K. and Emerick,J.M. \<br\>Purification and characterization of procathepsin L, a self-processing zymogen of guinea pig spermatozoa that acts on a cathepsin D assay substrate\<br\>Arch Biochem Biophys (1995) 323, 409-422. PubMed  Europe PubMed DOI  A
  472. Takeda,A., Yamamoto,T., Nakamura,Y., Takahashi,T. and Hibino,T. \<br\>Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L\<br\>FEBS Lett (1995) 359, 78-80. PubMed  Europe PubMed DOI
  473. Werle,B., Ebert,W., Klein,W. and Spiess,E. \<br\>Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue\<br\>Biol Chem Hoppe Seyler (1995) 376, 157-164. PubMed  Europe PubMed  I
  474. 1994
  475. Bromme,D., Bonneau,P.R., Lachance,P. and Storer,A.C. \<br\>Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity\<br\>J Biol Chem (1994) 269, 30238-30242. PubMed  Europe PubMed
  476. [YEAR:1-7-1994]Dowd,A.J., Smith,A.M., McGonigle,S. and Dalton,J.P. \<br\>Purification and characterisation of a second cathepsin L proteinase secreted by the parasitic trematode Fasciola hepatica\<br\>Eur J Biochem (1-7-1994) 223, 91-98. PubMed  Europe PubMed DOI
  477. Gour-Salin,B.J., Lachance,P., Bonneau,P.R., Storer,A.C., Kirschke,H. and Bromme,D. \<br\>E-64 analogs as inhibitors of cathepsin L and cathepsin S: importance of the S2-P2 interactions for potency and selectivity\<br\>Bioorg Chem (1994) 22, 227-241.  I
  478. Kirschke,H. and Wiederanders,B. \<br\>Cathepsin S and related lysosomal endopeptidases\<br\>Methods Enzymol (1994) 244, 500-511. PubMed  Europe PubMed DOI  V
  479. [YEAR:15-5-1994]Tao,K., Stearns,N.A., Dong,J., Wu,Q.L. and Sahagian,G.G. \<br\>The proregion of cathepsin L is required for proper folding, stability, and ER exit\<br\>Arch Biochem Biophys (15-5-1994) 311, 19-27. PubMed  Europe PubMed DOI
  480. 1993
  481. [YEAR:25-9-1993]Hook,V.Y., Purviance,R.T., Azaryan,A.V., Hubbard,G. and Krieger,T.J. \<br\>Purification and characterization of alpha 1-antichymotrypsin-like protease inhibitor that regulates prohormone thiol protease involved in enkephalin precursor processing\<br\>J Biol Chem (25-9-1993) 268, 20570-20577. PubMed  Europe PubMed
  482. [YEAR:3-5-1993]Ishidoh,K., Takeda-Ezaki,M. and Kominami,E. \<br\>Procathepsin L-specific antibodies that recognize procathepsin L but not cathepsin L\<br\>FEBS Lett (3-5-1993) 322, 79-82. PubMed  Europe PubMed DOI
  483. Kane,S.E. \<br\>Mouse procathepsin L lacking a functional glycosylation site is properly folded, stable, and secreted by NIH 3T3 cells\<br\>J Biol Chem (1993) 268, 11456-11462. PubMed  Europe PubMed
  484. Menard,R., Carmona,E., Plouffe,C., Bromme,D., Konishi,Y., Lefebvre,J. and Storer,A.C. \<br\>The specificity of the S1' subsite of cysteine proteases\<br\>FEBS Lett (1993) 328, 107-110. PubMed  Europe PubMed DOI
  485. 1992
  486. Dolenc,I., Ritonja,A., Colic,A., Podobnik,M., Ogrinc,T. and Turk,V. \<br\>Bovine cathepsins S and L: isolation and amino acid sequences\<br\>Biol Chem Hoppe Seyler (1992) 373, 407-412. PubMed  Europe PubMed
  487. Pike,R.N., Coetzer,T.H. and Dennison,C. \<br\>Proteolytically active complexes of cathepsin L and a cysteine proteinase inhibitor; purification and demonstration of their formation in vitro\<br\>Arch Biochem Biophys (1992) 294, 623-629. PubMed  Europe PubMed DOI
  488. 1991
  489. Ritonja,A., Colic,A., Dolenc,I., Ogrinc,T., Podobnik,M. and Turk,V. \<br\>The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L\<br\>FEBS Lett (1991) 283, 329-331. PubMed  Europe PubMed DOI
  490. Tchoupe,J.R., Moreau,T., Gauthier,F. and Bieth,J.G. \<br\>Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group\<br\>Biochim Biophys Acta (1991) 1076, 149-151. PubMed  Europe PubMed DOI  A
  491. 1990
  492. Nguyen,Q., Mort,J.S. and Roughley,P.J. \<br\>Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B\<br\>Biochem J (1990) 266, 569-573. PubMed  Europe PubMed  PMC  EPMC
  493. Stearns,N.A., Dong,J.M., Pan,J.X., Brenner,D.A. and Sahagian,G.G. \<br\>Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels\<br\>Arch Biochem Biophys (1990) 283, 447-457. PubMed  Europe PubMed DOI
  494. 1989
  495. Fan,Y.S., Byers,M.G., Eddy,R.L., Joseph,L., Sukhatme,V., Chan,S.J. and Shows,T.B. \<br\>Cathepsin L (CTSL) is located in the chromosome 9q21-q22 region; a related sequence is located on chromosome 10\<br\>Cytogenet Cell Genet (1989) 51, 996.
  496. Mason,R.W., Wilcox,D., Wikstrom,P. and Shaw,E.N. \<br\>The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor\<br\>Biochem J (1989) 257, 125-129. PubMed  Europe PubMed  PMC  EPMC
  497. Pike,R. and Dennison,C. \<br\>A high yield method for the isolation of sheep's liver cathepsin L\<br\>Prep Biochem (1989) 19, 231-245. PubMed  Europe PubMed DOI
  498. [YEAR:16-10-1989]Rozhin,J., Wade,R.L., Honn,K.V. and Sloane,B.F. \<br\>Membrane-associated cathepsin L: a role in metastasis of melanomas\<br\>Biochem Biophys Res Commun (16-10-1989) 164, 556-561. PubMed  Europe PubMed
  499. Smith,S.M. and Gottesman,M.M. \<br\>Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli\<br\>J Biol Chem (1989) 264, 20487-20495. PubMed  Europe PubMed  E
  500. [YEAR:1-8-1989]Wiederanders,B. and Kirschke,H. \<br\>The processing of a cathepsin L precursor in vitro\<br\>Arch Biochem Biophys (1-8-1989) 272, 516-521. PubMed  Europe PubMed
  501. 1988
  502. Crawford,C., Mason,R.W., Wikstrom,P. and Shaw,E. \<br\>The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B\<br\>Biochem J (1988) 253, 751-758. PubMed  Europe PubMed  PMC  EPMC  I
  503. Hiwasa,T., Sakiyama,S., Yokoyama,S., Ha,J.M., Fujita,J., Noguchi,S., Bando,Y., Kominami,E. and Katunuma,N. \<br\>Inhibition of cathepsin L-induced degradation of epidermal growth factor receptors by c-Ha-ras gene products\<br\>Biochem Biophys Res Commun (1988) 151, 78-85. PubMed  Europe PubMed
  504. Joseph,L.J., Chang,L.C., Stamenkovich,D. and Sukhatme,V.P. \<br\>Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts\<br\>J Clin Invest (1988) 81, 1621-1629. PubMed  Europe PubMed DOI  PMC  EPMC
  505. Ritonja,A., Popovic,T., Kotnik,M., Machleidt,W. and Turk,V. \<br\>Amino acid sequences of the human kidney cathepsins H and L\<br\>FEBS Lett (1988) 228, 341-345. PubMed  Europe PubMed
  506. 1987
  507. Dufour,E., Obled,A., Valin,C., Bechet,D., Ribadeau-Dumas,B. and Huet,J.C. \<br\>Purification and amino acid sequence of chicken liver cathepsin L\<br\>Biochemistry (1987) 26, 5689-5695. PubMed  Europe PubMed
  508. 1986
  509. Gal,S. and Gottesman,M.M. \<br\>The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity\<br\>Biochem Biophys Res Commun (1986) 139, 156-162. PubMed  Europe PubMed  P
  510. Johnson,D.A., Barrett,A.J. and Mason,R.W. \<br\>Cathepsin L inactivates alpha1-proteinase inhibitor by cleavage in the reactive site region\<br\>J Biol Chem (1986) 261, 14748-14751. PubMed  Europe PubMed
  511. Kirschke,H., Schmidt,I. and Wiederanders,B. \<br\>Cathepsin S. The cysteine proteinase from bovine lymphoid tissue is distinct from cathepsin L (EC 3.4.22.15)\<br\>Biochem J (1986) 240, 455-459. PubMed  Europe PubMed  PMC  EPMC
  512. 1985
  513. Etherington,D.J., Maciewicz,R.A., Mason,R.W., Taylor,M.A. and Wardale,R.J. \<br\>A comparative study of cathepsins N and L and their distribution in different tissues\<br\>Prog Clin Biol Res (1985) 180, 223-224. PubMed  Europe PubMed
  514. Mason,R.W., Green,G.D. and Barrett,A.J. \<br\>Human liver cathepsin L\<br\>Biochem J (1985) 226, 233-241. PubMed  Europe PubMed  PMC  EPMC
  515. 1984
  516. Hook,V.Y. and Loh,Y.P. \<br\>Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary\<br\>Proc Natl Acad Sci U S A (1984) 81, 2776-2780. PubMed  Europe PubMed  PMC  EPMC  I
  517. 1982
  518. [YEAR:22-2-1982]Pagano,M. and Engler,R. \<br\>Inhibition of human liver cathepsin L by alpha-thiol proteinase inhibitor\<br\>FEBS Lett (22-2-1982) 138, 307-310. PubMed  Europe PubMed
  519. 1981
  520. Barrett,A.J. and Kirschke,H. \<br\>Cathepsin B, cathepsin H and cathepsin L\<br\>Methods Enzymol (1981) 80, 535-561. PubMed  Europe PubMed DOI  V
  521. [YEAR:17-3-1981]Gottesman,M.M. and Cabral,F. \<br\>Purification and characterization of a transformation-dependent protein secreted by cultured murine fibroblasts\<br\>Biochemistry (17-3-1981) 20, 1659-1665. PubMed  Europe PubMed
  522. Kargel,H.J., Dettmer,R., Etzold,G., Kirschke,H., Bohley,P. and Langner,J. \<br\>Action of rat liver cathepsin L on glucagon\<br\>Acta Biol Med Ger (1981) 40, 1139-1143. PubMed  Europe PubMed
  523. 1980
  524. [YEAR:28-3-1980]Hibino,T., Fukuyama,K. and Epstein,W.L. \<br\>In vitro and in vivo inhibition of rat liver cathepsin L by epidermal proteinase inhibitor\<br\>Biochem Biophys Res Commun (28-3-1980) 93, 440-447. PubMed  Europe PubMed
  525. Kargel,H.J., Dettmer,R., Etzold,G., Kirschke,H., Bohley,P. and Langner,J. \<br\>Action of cathepsin L on the oxidized B-chain of bovine insulin\<br\>FEBS Lett (1980) 114, 257-260. PubMed  Europe PubMed
  526. 1978
  527. Gottesman,M.M. \<br\>Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts\<br\>Proc Natl Acad Sci U S A (1978) 75, 2767-2771. PubMed  Europe PubMed  PMC  EPMC
  528. 1976
  529. Kirschke,H., Langner,J., Wiederanders,B., Ansorge,S., Bohley,P. and Broghammer,U. \<br\>[Intracellular protein breakdown. VII. Cathepsin L and H; two new proteinases from rat liver lysosomes]\<br\>Acta Biol Med Ger (1976) 35, 285-299. PubMed  Europe PubMed