Literature for peptidase C01.032: cathepsin L
(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)
- Bestle,D., Bittel,L., Werner,A.D., Kamper,L., Dolnik,O., Krahling,V., Steinmetzer,T. and Bottcher-Friebertshauser,E. \<br\>Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage\<br\>Virus Res (2024) 347, 199430. PubMed Europe PubMed DOI K
- Chiang,Y.R., Lin,H.T., Chang,C.W., Lin,S.M. and Lin,J.H. \<br\>Dynamic expression of cathepsin L in the black soldier fly (Hermetia illucens) gut during Escherichia coli challenge\<br\>PLoS ONE (2024) 19, e0298338. PubMed Europe PubMed DOI PMC EPMC
- Ciaglia,T., Vestuto,V., Di Sarno,V., Musella,S., Smaldone,G., Di Matteo,F., Napolitano,V., Miranda,M.R., Pepe,G., Basilicata,M.G., Novi,S., Capolupo,I., Bifulco,G., Campiglia,P., Gomez-Monterrey,I., Snoeck,R., Andrei,G., Manfra,M., Ostacolo,C., Lauro,G. and Bertamino,A. \<br\>Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization\<br\>Eur J Med Chem (2024) 266, 116128. PubMed Europe PubMed DOI I
- Deng,W., Hu,X., Tian,X., Zhang,Y., Shang,W., Zhang,L. and Shang,L. \<br\>Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L\<br\>J Med Chem (2024) PubMed Europe PubMed DOI I
- Falke,S., Lieske,J., Herrmann,A., Loboda,J., Karnicar,K., Gunther,S., Reinke,P.Y.A., Ewert,W., Usenik,A., Lindic,N., Sekirnik,A., Dretnik,K., Tsuge,H., Turk,V., Chapman,H.N., Hinrichs,W., Ebert,G., Turk,D. and Meents,A. \<br\>Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors\<br\>J Med Chem (2024) PubMed Europe PubMed DOI I
- Kim,M.J., Kim,S., Reinheckel,T. and Krainc,D. \<br\>Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase\<br\>JCI Insight (2024) 9, PubMed Europe PubMed DOI PMC EPMC
- Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X. \<br\>Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19\<br\>Med (2024) 5, 169-171. PubMed Europe PubMed DOI I
- Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X. \<br\>Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19\<br\>Med (2024) 5, 42-61. PubMed Europe PubMed DOI I
- Matouskova,Z., Orsaghova,K., Srb,P., Pytelkova,J., Kukacka,Z., Busa,M., Hajdusek,O., Sima,R., Fabry,M., Novak,P., Horn,M., Kopacek,P. and Mares,M. \<br\>An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans\<br\>Int J Mol Sci (2024) 25, PubMed Europe PubMed DOI PMC EPMC
- Matsuki,A., Watanabe,Y., Hashimoto,S., Hoshino,A. and Matoba,S. \<br\>Cathepsin L prevents the accumulation of alpha-synuclein fibrils in the cell\<br\>Genes Cells (2024) 29, 328-336. PubMed Europe PubMed DOI
- Oliveira,B.R., Nehlmeier,I., Kempf,A.M., Venugopalan,V., Rehders,M., Ceniza,M.E.P., Cavalcanti,P.A.T.P., Hoffmann,M., Pohlmann,S. and Brix,K. \<br\>Cytoskeletal beta-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y\<br\>Biochimie (2024) PubMed Europe PubMed DOI
- Peng,Z., Luo,X.Y., Li,X., Li,Y., Wu,Y., Tian,Y., Pan,B., Petrovic,A., Kosanovic,D., Schermuly,R.T., Ruppert,C., Gunther,A., Zhang,Z., Qiu,C., Li,Y., Pu,J., Li,X. and Chen,A.F. \<br\>Cathepsin L Promotes Pulmonary Hypertension via BMPR2/GSDME-Mediated Pyroptosis\<br\>Hypertension (2024) PubMed Europe PubMed DOI
- Previti,S., Ettari,R., Calcaterra,E., Roggia,M., Natale,B., Weldert,A.C., Muller-Ruttloff,C., Salisch,F., Irto,A., Cigala,R.M., Ziebuhr,J., Schirmeister,T., Cosconati,S. and Zappala,M. \<br\>Identification of Dual Inhibitors Targeting Main Protease (M(pro)) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents\<br\>ACS Med Chem Lett (2024) 15, 602-609. PubMed Europe PubMed DOI PMC EPMC
- Wu,Y., Jiang,D., Liu,Q., Yan,S., Liu,X., Wu,T., Sun,W. and Li,G. \<br\>Cathepsin L induces cellular senescence by upregulating CUX1 and p16(INK4a)\<br\>Aging (Albany NY) (2024) 16, PubMed Europe PubMed DOI
- Xie,X., Lan,Q., Zhao,J., Zhang,S., Liu,L., Zhang,Y., Xu,W., Shao,M., Peng,J., Xia,S., Zhu,Y., Zhang,K., Zhang,X., Zhang,R., Li,J., Dai,W., Ge,Z., Hu,S., Yu,C., Wang,J., Ma,D., Zheng,M., Yang,H., Xiao,G., Rao,Z., Lu,L., Zhang,L., Bai,F., Zhao,Y., Jiang,S. and Liu,H. \<br\>Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1\<br\>Signal Transduct Target Ther (2024) 9, 54. PubMed Europe PubMed DOI PMC EPMC I
- Xu,B., Anderson,B.M., Mountford,S.J., Thompson,P.E., Mintern,J.D. and Edgington-Mitchell,L.E. \<br\>Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate\<br\>Biol Chem (2024) PubMed Europe PubMed DOI
- Yang,H., Zhou,J.N., Zhang,X.M., Ling,D.D., Sun,Y.B., Li,C.Y., Zhou,Q.Q., Shi,G.N., Wang,S.H., Lin,X.S., Fan,T., Wang,H.Y., Zeng,Q., Jia,Y.L., Xi,J.F., Jin,Y.G., Pei,X.T. and Yue,W. \<br\>Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS-CoV-2 Pseudovirus Entry into Lung ACE2(+) Cells\<br\>Adv Mater (2024) e2310306. PubMed Europe PubMed DOI
- Zhang,Z., Wang,J., Shi,Y., Wang,B. and Wang,D. \<br\>Cathepsin L promotes oesophageal squamous cell carcinoma development and may be associated with tumour-associated macrophages\<br\>Heliyon (2024) 10, e29273. PubMed Europe PubMed DOI PMC EPMC
- Zhou,W., You,B., Zhao,X., Si,S., Li,Y. and Zhang,J. \<br\>Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors\<br\>SLAS Discov (2024) 29, 100153. PubMed Europe PubMed DOI I
- Zhou,W., You,B., Zheng,Y., Si,S., Li,Y. and Zhang,J. \<br\>Expression, purification, and biological activity evaluation of cathepsin L in mammalian cells\<br\>Biosci Biotechnol Biochem (2024) 88, 405-411. PubMed Europe PubMed DOI
- Abdelaziz,R.F., Hussein,A.M., Kotob,M.H., Weiss,C., Chelminski,K., Stojanovic,T., Studenik,C.R. and Aufy,M. \<br\>Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells\<br\>Int J Mol Sci (2023) 24, PubMed Europe PubMed DOI PMC EPMC
- Doijen,J., Temmerman,K., Van den Eynde,C., Diels,A., Van den Broeck,N., Van Gool,M., Heo,I., Jaensch,S., Zwaagstra,M., Diosa Toro,M., Chiu,W., De Jonghe,S., Leyssen,P., Bojkova,D., Ciesek,S., Cinatl,J., Verschueren,L., Buyck,C., van Kuppeveld,F., Neyts,J., Van Loock,M. and Van Damme,E. \<br\>Identification of Z-Tyr-Ala-CHN(2), a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2\<br\>Microorganisms (2023) 11, PubMed Europe PubMed DOI PMC EPMC I
- Ezz,M.A., Takahashi,M., Rivera,R.M. and Balboula,A.Z. \<br\>Cathepsin L regulates oocyte meiosis and preimplantation embryo development\<br\>Cell Prolif (2023) e13526. PubMed Europe PubMed DOI
- Fernandez-de-la-Pradilla,A., Royo,S., Schirmeister,T., Barthels,F., Swiderek,K., Gonzalez,F.V. and Moliner,V. \<br\>Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L\<br\>ACS Catal (2023) 13, 13354-13368. PubMed Europe PubMed DOI PMC EPMC
- Grozdanic,M., Sobotic,B., Biasizzo,M., Sever,T., Vidmar,R., Vizovisek,M., Turk,B. and Fonovic,M. \<br\>Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer\<br\>Biol Chem (2023) PubMed Europe PubMed DOI
- Huang,H., Zhang,Y., Xu,X., Liu,Y., Zhao,J., Ma,L., Lei,J., Ge,W., Li,N., Ma,E., Li,Y. and Yuan,L. \<br\>Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells\<br\>Bioorg Med Chem Lett (2023) 80, 129087. PubMed Europe PubMed DOI I
- Kondo,Y., Rajapakse,S. and Ogiwara,K. \<br\>Involvement of cathepsin L in the degradation and degeneration of postovulatory follicle of the medaka ovarydagger\<br\>Biol Reprod (2023) 109, 904-917. PubMed Europe PubMed DOI
- Li,Y., Wang,K., Sun,H., Wu,S., Wang,H., Shi,Y., Li,X., Yan,H., Yang,G., Wu,M., Li,Y., Ding,X., Si,S., Jiang,J., Du,Y., Li,Y. and Hong,B. \<br\>Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2\<br\>Antiviral Res (2023) 214, 105606. PubMed Europe PubMed DOI PMC EPMC I
- Tang,T.T., Li,S.M., Pan,B.W., Xiao,J.W., Pang,Y.X., Xie,S.X., Zhou,Y., Yang,J. and Wei,Y. \<br\>Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure-Activity Relationships\<br\>Molecules (2023) 28, PubMed Europe PubMed DOI PMC EPMC I
- Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D. \<br\>Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins\<br\>Commun Biol (2023) 6, 450. PubMed Europe PubMed DOI PMC EPMC
- Wang,C., Ye,X., Ding,C., Zhou,M., Li,W., Wang,Y., You,Q., Zong,S., Peng,Q., Duanmu,D., Chen,H., Sun,B. and Qiao,J. \<br\>Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry\<br\>J Agric Food Chem (2023) 71, 5535-5546. PubMed Europe PubMed DOI PMC EPMC I
- Denamur,S., Chazeirat,T., Maszota-Zieleniak,M., Vives,R.R., Saidi,A., Zhang,F., Linhardt,R.J., Labarthe,F., Samsonov,S.A., Lalmanach,G. and Lecaille,F. \<br\>Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: Putative consequences in mucopolysaccharidosis\<br\>Carbohydr Polym (2022) 293, 119734. PubMed Europe PubMed DOI
- Gaikwad,P. and Kemp,M.G. \<br\>Cathepsin L inhibition prevents the cleavage of multiple nuclear proteins upon lysis of quiescent human cells\<br\>MicroPubl Biol (2022) 2022, PubMed Europe PubMed DOI PMC EPMC
- Islam,M.I., Nagakannan,P., Shcholok,T., Contu,F., Mai,S., Albensi,B.C., Del Bigio,M.R., Wang,J.F., Sharoar,M.G., Yan,R., Park,I.S. and Eftekharpour,E. \<br\>Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer's disease\<br\>Aging Cell (2022) 21, e13531. PubMed Europe PubMed DOI
- Kladnik,J., Dolinar,A., Kljun,J., Perea,D., Grau-Exposito,J., Genesca,M., Novinec,M., Buzon,M.J. and Turel,I. \<br\>Zinc pyrithione is a potent inhibitor of PL(Pro) and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication\<br\>J Enzyme Inhib Med Chem (2022) 37, 2158-2168. PubMed Europe PubMed DOI PMC EPMC
- Kwon,C.W., Yeo,S. and Chang,P.S. \<br\>Characterization and molecular docking study of cathepsin L inhibitory peptides (SnuCalCpIs) from Calotropis procera R. Br\<br\>Sci Rep (2022) 12, 5825. PubMed Europe PubMed DOI PMC EPMC I
- Li,C., Liu,Z., Chen,M., Zhang,L., Shi,R. and Zhong,H. \<br\>Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence\<br\>Biology (Basel) (2022) 12, PubMed Europe PubMed DOI PMC EPMC
- Meewan,I., Kattoula,J., Kattoula,J.Y., Skinner,D., Fajtova,P., Giardini,M.A., Woodworth,B., McKerrow,J.H., Lage de Siqueira-Neto,J., O'Donoghue,A.J. and Abagyan,R. \<br\>Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L\<br\>Pharmaceuticals (Basel) (2022) 15, PubMed Europe PubMed DOI PMC EPMC I
- Mondal,S., Chen,Y., Lockbaum,G.J., Sen,S., Chaudhuri,S., Reyes,A.C., Lee,J.M., Kaur,A.N., Sultana,N., Cameron,M.D., Shaffer,S.A., Schiffer,C.A., Fitzgerald,K.A. and Thompson,P.R. \<br\>Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2\<br\>J Am Chem Soc (2022) 144, 21035-21045. PubMed Europe PubMed DOI PMC EPMC K I
- Mouawad,J.E., Sharma,S., Renaud,L., Pilewski,J.M., Nadig,S.N. and Feghali-Bostwick,C. \<br\>Reduced Cathepsin L Expression and Secretion into the Extracellular Milieu Contribute to Lung Fibrosis in Systemic Sclerosis\<br\>Rheumatology (Oxford) (2022) PubMed Europe PubMed DOI
- Novinec,M., Bembic,P., Jankovic,M., Kisilak,M., Kljun,J. and Turel,I. \<br\>Kinetic Characterization of Cerium and Gallium Ions as Inhibitors of Cysteine Cathepsins L, K, and S\<br\>Int J Mol Sci (2022) 23, PubMed Europe PubMed DOI PMC EPMC
- Wang,S., Luke,C.J., Pak,S.C., Shi,V., Chen,L., Moore,J., Andress,A.P., Jayachandran,K., Zhang,J., Huang,Y., Platik,M., Apicelli,A.A., Schwarz,J.K., Grigsby,P.W., Silverman,G.A. and Markovina,S. \<br\>SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation\<br\>Commun Biol (2022) 5, 46. PubMed Europe PubMed DOI PMC EPMC
- Wang,X., Liu,D., Liu,F., Xiao,L., Ni,H., Qi,X., Xing,K., Cai,D., Sheng,X. and Guo,Y. \<br\>Cathepsin L involved in the freezing resistance of murine normal hatching embryos and dormant embryos\<br\>Reprod Biol (2022) 22, 100612. PubMed Europe PubMed DOI
- Yang,W.L., Li,Q., Sun,J., Huat Tan,S., Tang,Y.H., Zhao,M.M., Li,Y.Y., Cao,X., Zhao,J.C. and Yang,J.K. \<br\>Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy\<br\>Comput Struct Biotechnol J (2022) 20, 2442-2454. PubMed Europe PubMed DOI PMC EPMC I
- Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V. \<br\>Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases\<br\>ACS Chem Neurosci (2022) 13, 245-256. PubMed Europe PubMed DOI
- Yu,F., Pan,T., Huang,F., Ying,R., Liu,J., Fan,H., Zhang,J., Liu,W., Lin,Y., Yuan,Y., Yang,T., Li,R., Zhang,X., Lv,X., Chen,Q., Liang,A., Zou,F., Liu,B., Hu,F., Tang,X., Li,L., Deng,K., He,X., Zhang,H., Zhang,Y. and Ma,X. \<br\>Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L\<br\>Front Microbiol (2022) 13, 884034. PubMed Europe PubMed DOI PMC EPMC I
- Zhao,M.M., Zhu,Y., Zhang,L., Zhong,G., Tai,L., Liu,S., Yin,G., Lu,J., He,Q., Li,M.J., Zhao,R.X., Wang,H., Huang,W., Fan,C., Shuai,L., Wen,Z., Wang,C., He,X., Chen,Q., Liu,B., Xiong,X., Bu,Z., Wang,Y., Sun,F. and Yang,J.K. \<br\>Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies\<br\>Cell Discov (2022) 8, 53. PubMed Europe PubMed DOI PMC EPMC
- Berdowska,I. and Matusiewicz,M. \<br\>Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis - with impact on gastrointestinal tract\<br\>World J Gastroenterol (2021) 27, 6590-6600. PubMed Europe PubMed DOI PMC EPMC
- Bollavaram,K., Leeman,T.H., Lee,M.W., Kulkarni,A., Upshaw,S.G., Yang,J., Song,H. and Platt,M.O. \<br\>Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V\<br\>Protein Sci (2021) PubMed Europe PubMed DOI
- Breidenbach,J., Lemke,C., Pillaiyar,T., Schakel,L., Al Hamwi,G., Diett,M., Gedschold,R., Geiger,N., Lopez,V., Mirza,S., Namasivayam,V., Schiedel,A.C., Sylvester,K., Thimm,D., Vielmuth,C., Phuong Vu,L., Zyulina,M., Bodem,J., Gutschow,M. and Muller,C.E. \<br\>Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors\<br\>Angew Chem Int Ed Engl (2021) PubMed Europe PubMed DOI I
- Caval,T., Hecht,E.S., Tang,W., Uy-Gomez,M., Nichols,A., Kil,Y.J., Sandoval,W., Bern,M. and Heck,A.J.R. \<br\>The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies\<br\>FEBS J (2021) PubMed Europe PubMed DOI
- Choudhury,D. and Biswas,S. \<br\>Structure-guided protein engineering of human cathepsin L for efficient collagenolytic activity\<br\>Protein Eng Des Sel (2021) 34, PubMed Europe PubMed DOI
- Dominguez-Hernandez,E. and Ertbjerg,P. \<br\>Effect of LTLT heat treatment on cathepsin B and L activities and denaturation of myofibrillar proteins of pork\<br\>Meat Sci (2021) 175, 108454. PubMed Europe PubMed DOI
- Eckl,K.M., Gruber,R., Brennan,L., Marriott,A., Plank,R., Moosbrugger-Martinz,V., Blunder,S., Schossig,A., Altmuller,J., Thiele,H., Nurnberg,P., Zschocke,J., Hennies,H.C. and Schmuth,M. \<br\>Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V\<br\>Front Genet (2021) 12, 689940. PubMed Europe PubMed DOI PMC EPMC
- Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J. \<br\>Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses\<br\>ACS Infect Dis (2021) 7, 586-597. PubMed Europe PubMed DOI PMC EPMC I
- Huang,M., Chen,S.P., Dai,Y.Y., Yang,Y., Jiang,W., Wang,F., Zhang,J.X. and Zhu,Q.X. \<br\>[Cathepsin L mediates glomerular endothelial cell injury by cleavaging complement C3 in trichloroethylene-sensitized mice]\<br\>Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2021) 39, 5-11. PubMed Europe PubMed DOI
- IstIflI,E.S., SihoGlu Tepe,A., Netz,P.A., SarikUrkcU,C., Kilic,I.H. and Tepe,B. \<br\>Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols\<br\>Turk J Biol (2021) 45, 484-502. PubMed Europe PubMed DOI PMC EPMC
- Jackson,C.B., Farzan,M., Chen,B. and Choe,H. \<br\>Mechanisms of SARS-CoV-2 entry into cells\<br\>Nat Rev Mol Cell Biol (2021) PubMed Europe PubMed DOI PMC EPMC V
- Kim,J.Y., Lee,E.J., Ahn,Y., Park,S., Bae,Y.J., Kim,T.G. and Oh,S.H. \<br\>Cathepsin L, a Target of Hypoxia-Inducible Factor-1-alpha, Is Involved in Melanosome Degradation in Melanocytes\<br\>Int J Mol Sci (2021) 22, PubMed Europe PubMed DOI PMC EPMC
- Li,Y., Ai,X., Zou,C., Liu,Y., Ma,L., Men,J., Liu,D., Sheng,L., Ruan,X., Liu,H., Li,W., Ma,E. and Yuan,L. \<br\>Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells\<br\>Bioorg Chem (2021) 115, 105256. PubMed Europe PubMed DOI I
- Mellott,D.M., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D.H., Hsu,J., Zhu,J., Taylor,Z.W., Kocurek,K.I., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Yoon,M.C., Beck,S., Carlin,A.F., Clark,A.E., Beretta,L., Maneval,D., Hook,V., Frueh,F., Hurst,B.L., Wang,H., Raushel,F.M., O'Donoghue,A.J., de Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H. \<br\>A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells\<br\>ACS Chem Biol (2021) 16, 642-650. PubMed Europe PubMed DOI PMC EPMC I
- Munikishore,R., Wang,L.L., Zhang,S., Zhao,Q.S. and Zuo,Z. \<br\>An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94\<br\>Bioorg Chem (2021) 116, 105317. PubMed Europe PubMed DOI I
- Pathak,M., Vani,V. and Seshagiri,P.B. \<br\>Expression and function of interleukin-1beta is required for hamster blastocyst hatching: Involvement of hatching-associated cathepsin proteases\<br\>Mol Reprod Dev (2021) 88, 274-286. PubMed Europe PubMed DOI
- Phan,H.A.T., Giannakoulias,S.G., Barrett,T.M., Liu,C. and Petersson,E.J. \<br\>Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L\<br\>Chem Sci (2021) 12, 10825-10835. PubMed Europe PubMed DOI PMC EPMC I
- Reed,B., Crawford,F., Hill,R.C., Jin,N., White,J., Krovi,S.H., Marrack,P., Hansen,K. and Kappler,J.W. \<br\>Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation\<br\>J Exp Med (2021) 218, PubMed Europe PubMed DOI
- Shibamura-Fujiogi,M., Yuki,K. and Hou,L. \<br\>Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis\<br\>Int Immunopharmacol (2021) 93, 107425. PubMed Europe PubMed DOI
- Steuten,K., Kim,H., Widen,J.C., Babin,B.M., Onguka,O., Lovell,S., Bolgi,O., Cerikan,B., Neufeldt,C.J., Cortese,M., Muir,R.K., Bennett,J.M., Geiss-Friedlander,R., Peters,C., Bartenschlager,R. and Bogyo,M. \<br\>Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19\<br\>ACS Infect Dis (2021) PubMed Europe PubMed DOI PMC EPMC
- Yang,J., Chen,T. and Zhou,Y. \<br\>Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes\<br\>Hereditas (2021) 158, 4. PubMed Europe PubMed DOI PMC EPMC
- Zhao,M.M., Yang,W.L., Yang,F.Y., Zhang,L., Huang,W.J., Hou,W., Fan,C.F., Jin,R.H., Feng,Y.M., Wang,Y.C. and Yang,J.K. \<br\>Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development\<br\>Signal Transduct Target Ther (2021) 6, 134. PubMed Europe PubMed DOI PMC EPMC K
- Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R. \<br\>Potential protease inhibitors and their combinations to block SARS-CoV-2\<br\>J Biomol Struct Dyn (2020) 1-15. PubMed Europe PubMed DOI PMC EPMC I
- Almasi,F. and Mohammadipanah,F. \<br\>Hypothetical targets and plausible drugs of coronavirus infection caused by SARS-CoV-2\<br\>Transbound Emerg Dis (2020) PubMed Europe PubMed DOI PMC EPMC
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- Zhou,N., Pan,T., Zhang,J., Li,Q., Zhang,X., Bai,C., Huang,F., Peng,T., Zhang,J., Liu,C., Tao,L. and Zhang,H. \<br\>Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)\<br\>J Biol Chem (2016) 291, 9218-9232. PubMed Europe PubMed DOI I
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- Ofori,L.O., Withana,N.P., Prestwood,T.R., Verdoes,M., Brady,J.J., Winslow,M.M., Sorger,J. and Bogyo,M. \<br\>Design of protease activated optical contrast agents that exploit a latent lysosomotropic effect for use in fluorescence-guided surgery\<br\>ACS Chem Biol (2015) 10, 1977-1988. PubMed Europe PubMed DOI L
- Parker,E.N., Song,J., Kishore Kumar,G.D., Odutola,S.O., Chavarria,G.E., Charlton-Sevcik,A.K., Strecker,T.E., Barnes,A.L., Sudhan,D.R., Wittenborn,T.R., Siemann,D.W., Horsman,M.R., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L\<br\>Bioorg Med Chem (2015) 23, 6974-6992. PubMed Europe PubMed DOI I
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- Wang,H., Sang,N., Zhang,C., Raghupathi,R., Tanzi,R.E. and Saunders,A. \<br\>Cathepsin L mediates the degradation of novel APP C-terminal fragments\<br\>Biochemistry (2015) 54, 2806-2816. PubMed Europe PubMed DOI I
- Wang,R., Song,L., Su,B., Zhao,H., Zhang,D., Peatman,E. and Li,C. \<br\>Mucosal expression signatures of two cathepsin L in channel catfish (Ictalurus punctatus) following bacterial challenge\<br\>Fish Shellfish Immunol (2015) 47, 582-589. PubMed Europe PubMed DOI
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- Zhang,Q., Han,M., Wang,W., Song,Y., Chen,G., Wang,Z. and Liang,Z. \<br\>Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor-beta-mediated epithelial-mesenchymal transition\<br\>Oncol Rep (2015) 33, 1851-1859. PubMed Europe PubMed DOI
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- Hu,X., Hu,X., Hu,B., Wen,C., Xie,Y., Wu,D., Tao,Z., Li,A. and Gao,Q. \<br\>Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata\<br\>Fish Shellfish Immunol (2014) 40, 446-454. PubMed Europe PubMed DOI
- Kumaresan,V., Bhatt,P., Palanisamy,R., Gnanam,A.J., Pasupuleti,M. and Arockiaraj,J. \<br\>A murrel cysteine protease, cathepsin L: Bioinformatics characterization, gene expression and proteolytic activity\<br\>Biologia (2014) 69, 395-406. DOI
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- Miller,B., Friedman,A.J., Choi,H., Hogan,J., McCammon,J.A., Hook,V. and Gerwick,W.H. \<br\>The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L\<br\>J Nat Prod (2014) 77, 92-99. PubMed Europe PubMed DOI I
- Muller,S., Faulhaber,A., Sieber,C., Pfeifer,D., Hochberg,T., Gansz,M., Deshmukh,S.D., Dauth,S., Brix,K., Saftig,P., Peters,C., Henneke,P. and Reinheckel,T. \<br\>The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction\<br\>FASEB J (2014) 28, 162-175. PubMed Europe PubMed DOI
- Pietra,D., Borghini,A., Ricci,C. and Bianucci,A.M. \<br\>Enzyme kinetics studies on 29-kDa human liver cathepsin L\<br\>Chem Biol Drug Des (2014) 84, 648-658. PubMed Europe PubMed DOI
- Ramalho,S.D., De Sousa,L.R., Nebo,L., Maganhi,S.H., Caracelli,I., Zukerman-Schpector,J., Lima,M.I., Alves,M.F., da Silva,M.F., Fernandes,J.B. and Vieira,P.C. \<br\>Triterpenoids as novel natural inhibitors of human cathepsin L\<br\>Chem Biodivers (2014) 11, 1354-1363. PubMed Europe PubMed DOI I
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- Tholen,M., Hillebrand,L.E., Tholen,S., Sedelmeier,O., Arnold,S.J. and Reinheckel,T. \<br\>Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo\<br\>Nat Commun (2014) 5, 4931. PubMed Europe PubMed DOI
- Tholen,S., Biniossek,M.L., Gansz,M., Ahrens,T.D., Schlimpert,M., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O. \<br\>Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis\<br\>Cell Mol Life Sci (2014) 71, 899-916. PubMed Europe PubMed DOI K
- Arockiaraj,J., Gnanam,A.J., Muthukrishnan,D., Thirumalai,M.K., Pasupuleti,M., Milton,J. and Kasi,M. \<br\>Macrobrachium rosenbergii cathepsin L: molecular characterization and gene expression in response to viral and bacterial infections\<br\>Microbiol Res (2013) 168, 569-579. PubMed Europe PubMed DOI
- Badano,M.N., Camicia,G.L., Lombardi,G., Maglioco,A., Cabrera,G., Costa,H., Meiss,R.P., Piazzon,I. and Nepomnaschy,I. \<br\>B-cell lymphopoiesis is regulated by cathepsin L\<br\>PLoS ONE (2013) 8, e61347. PubMed Europe PubMed DOI PMC EPMC
- Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y. \<br\>Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors\<br\>Bioorg Chem (2013) 51, 24-30. PubMed Europe PubMed DOI I
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- Ehmke,V., Winkler,E., Banner,D.W., Haap,W., Schweizer,W.B., Rottmann,M., Kaiser,M., Freymond,C., Schirmeister,T. and Diederich,F. \<br\>Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L\<br\>ChemMedChem (2013) 8, 967-975. PubMed Europe PubMed DOI I
- Grotsky,D.A., Gonzalez-Suarez,I., Novell,A., Neumann,M.A., Yaddanapudi,S.C., Croke,M., Martinez-Alonso,M., Redwood,A.B., Ortega-Martinez,S., Feng,Z., Lerma,E., Ramon,Y.C., Zhang,J., Matias-Guiu,X., Dusso,A. and Gonzalo,S. \<br\>BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells\<br\>J Cell Biol (2013) 200, 187-202. PubMed Europe PubMed DOI PMC EPMC
- Niu,D., Jin,K., Wang,L., Feng,B. and Li,J. \<br\>Molecular characterization and expression analysis of four cathepsin L genes in the razor clam, Sinonovacula constricta\<br\>Fish Shellfish Immunol (2013) 35, 581-588. PubMed Europe PubMed DOI
- Ohkouchi,S., Shibata,M., Sasaki,M., Koike,M., Safig,P., Peters,C., Nagata,S. and Uchiyama,Y. \<br\>Biogenesis and proteolytic processing of lysosomal DNase II\<br\>PLoS ONE (2013) 8, e59148. PubMed Europe PubMed DOI PMC EPMC
- Song,J., Jones,L.M., Chavarria,G.E., Charlton-Sevcik,A.K., Jantz,A., Johansen,A., Bayeh,L., Soeung,V., Snyder,L.K., Lade,S.D., Jr., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks\<br\>Bioorg Med Chem Lett (2013) 23, 2801-2807. PubMed Europe PubMed DOI I
- Tholen,S., Biniossek,M.L., Gansz,M., Gomez-Auli,A., Bengsch,F., Noel,A., Kizhakkedathu,J.N., Boerries,M., Busch,H., Reinheckel,T. and Schilling,O. \<br\>Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome\<br\>Mol Cell Proteomics (2013) 12, 611-625. PubMed Europe PubMed DOI K
- Torkar,A., Lenarcic,B., Lah,T., Dive,V. and Devel,L. \<br\>Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?\<br\>Bioorg Med Chem Lett (2013) 23, 2968-2973. PubMed Europe PubMed DOI I
- Wang,Y.R., Qin,S., Han,R., Wu,J.C., Liang,Z.Q., Qin,Z.H. and Wang,Y. \<br\>Cathepsin L plays a role in quinolinic acid-induced NF-Kappab activation and excitotoxicity in rat striatal neurons\<br\>PLoS ONE (2013) 8, e75702. PubMed Europe PubMed DOI PMC EPMC I
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- Ehmke,V., Quinsaat,J.E., Rivera-Fuentes,P., Heindl,C., Freymond,C., Rottmann,M., Brun,R., Schirmeister,T. and Diederich,F. \<br\>Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors\<br\>Org Biomol Chem (2012) 10, 5764-5768. PubMed Europe PubMed DOI I
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- Mbewe-Campbell,N., Wei,Z., Zhang,K., Friese,R.S., Mahata,M., Schork,A.J., Rao,F., Chiron,S., Biswas,N., Kim,H.S., Mahata,S.K., Waalen,J., Nievergelt,C.M., Hook,V.Y. and O'Connor,D.T. \<br\>Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure\<br\>J Hypertens (2012) 30, 1961-1969. PubMed Europe PubMed DOI
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- Chung,J.H., Im,E.K., Jin,T., Lee,S.M., Kim,S.H., Choi,E.Y., Shin,M.J., Lee,K.H. and Jang,Y. \<br\>Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration\<br\>Exp Mol Med (2011) 43, 179-188. PubMed Europe PubMed DOI
- Funkelstein,L. and Hook,V. \<br\>The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression\<br\>Methods Mol Biol (2011) 768, 107-125. PubMed Europe PubMed DOI
- Gonzalez-Suarez,I., Redwood,A.B., Grotsky,D.A., Neumann,M.A., Cheng,E.H., Stewart,C.L., Dusso,A. and Gonzalo,S. \<br\>A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair\<br\>EMBO J (2011) 30, 3383-3396. PubMed Europe PubMed DOI
- Hardegger,L.A., Kuhn,B., Spinnler,B., Anselm,L., Ecabert,R., Stihle,M., Gsell,B., Thoma,R., Diez,J., Benz,J., Plancher,J.M., Hartmann,G., Isshiki,Y., Morikami,K., Shimma,N., Haap,W., Banner,D.W. and Diederich,F. \<br\>Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments\<br\>ChemMedChem (2011) 6, 2048-2054. PubMed Europe PubMed DOI S
- Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B. \<br\>Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C\<br\>J Immunol (2011) 186, 7136-7143. PubMed Europe PubMed DOI
- Savalas,L.R., Gasnier,B., Damme,M., Lubke,T., Wrocklage,C., Debacker,C., Jezegou,A., Reinheckel,T., Hasilik,A., Saftig,P. and Schroder,B. \<br\>Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L\<br\>Biochem J (2011) 439, 113-128. PubMed Europe PubMed DOI
- Schechter,I. and Ziv,E. \<br\>Cathepsins S, B and L with aminopeptidases display beta-secretase activity associated with the pathogenesis of Alzheimer's disease\<br\>Biol Chem (2011) 392, 555-569. PubMed Europe PubMed DOI
- Shenoy,R.T. and Sivaraman,J. \<br\>Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors\<br\>J Struct Biol (2011) 173, 14-19. PubMed Europe PubMed DOI I
- Sun,J., Sukhova,G.K., Zhang,J., Chen,H., Sjoberg,S., Libby,P., Xiang,M., Wang,J., Peters,C., Reinheckel,T. and Shi,G.P. \<br\>Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice\<br\>Arterioscler Thromb Vasc Biol (2011) 31, 2500-2508. PubMed Europe PubMed DOI K
- Sun,M., Chen,M., Liu,Y., Fukuoka,M., Zhou,K., Li,G., Dawood,F., Gramolini,A. and Liu,P.P. \<br\>Cathepsin-L contributes to cardiac repair and remodelling post-infarction\<br\>Cardiovasc Res (2011) 89, 374-383. PubMed Europe PubMed DOI K
- Tholen,S., Biniossek,M.L., Gessler,A.L., Muller,S., Weisser,J., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O. \<br\>Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts\<br\>Biol Chem (2011) 392, 961-971. PubMed Europe PubMed DOI K
- Whang,I., De Zoysa,M., Nikapitiya,C., Lee,Y., Kim,Y., Lee,S., Oh,C., Jung,S.J., Oh,M.J., Choi,C.Y., Yeo,S.Y., Kim,B.S., Kim,S.J. and Lee,J. \<br\>Molecular characterization and expression analysis of cathepsin B and L cysteine proteases from rock bream (Oplegnathus fasciatus)\<br\>Fish Shellfish Immunol (2011) 30, 763-772. PubMed Europe PubMed DOI
- Xiang,B., Fei,X., Zhuang,W., Fang,Y., Qin,Z. and Liang,Z. \<br\>Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells\<br\>Brain Res (2011) 1387, 29-38. PubMed Europe PubMed DOI I
- Ahn,S.J., Sung,J.H., Kim,N.Y., Lee,A.R., Jeon,S.J., Lee,J.S., Kim,J.K., Chung,J.K. and Lee,H.H. \<br\>Molecular cloning, expression, and characterization of cathepsin L from mud loach (Misgurnus mizolepis)\<br\>Appl Biochem Biotechnol (2010) 162, 1858-1871. PubMed Europe PubMed DOI
- Ceru,S., Konjar,S., Maher,K., Repnik,U., Krizaj,I., Bencina,M., Renko,M., Nepveu,A., Zerovnik,E., Turk,B. and Kopitar-Jerala,N. \<br\>Stefin B interacts with histones and cathepsin L in the nucleus\<br\>J Biol Chem (2010) 285, 10078-10086. PubMed Europe PubMed DOI
- Dennemarker,J., Lohmuller,T., Mayerle,J., Tacke,M., Lerch,M.M., Coussens,L.M., Peters,C. and Reinheckel,T. \<br\>Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis\<br\>Oncogene (2010) 29, 1611-1621. PubMed Europe PubMed DOI K
- Dennemarker,J., Lohmuller,T., Muller,S., Aguilar,S.V., Tobin,D.J., Peters,C. and Reinheckel,T. \<br\>Impaired turnover of autophagolysosomes in cathepsin L deficiency\<br\>Biol Chem (2010) 391, 913-922. PubMed Europe PubMed DOI K
- Fortenberry,Y.M., Brandal,S., Bialas,R.C. and Church,F.C. \<br\>Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration\<br\>Biochim Biophys Acta (2010) 1800, 580-590. PubMed Europe PubMed DOI
- Frizler,M., Stirnberg,M., Sisay,M.T. and Gutschow,M. \<br\>Development of nitrile-based peptidic inhibitors of cysteine cathepsins\<br\>Curr Top Med Chem (2010) 10, 294-322. PubMed Europe PubMed DOI T I
- Funkelstein,L., Beinfeld,M., Minokadeh,A., Zadina,J. and Hook,V. \<br\>Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides\<br\>Neuropeptides (2010) 44, 457-466. PubMed Europe PubMed DOI
- Higgins,W.J., Fox,D.M., Kowalski,P.S., Nielsen,J.E. and Worrall,D.M. \<br\>Heparin enhances serpin inhibition of the cysteine protease cathepsin L\<br\>J Biol Chem (2010) 285, 3722-3729. PubMed Europe PubMed DOI
- Hood,C.L., Abraham,J., Boyington,J.C., Leung,K., Kwong,P.D. and Nabel,G.J. \<br\>Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity\<br\>J Virol (2010) 84, 2972-2982. PubMed Europe PubMed DOI
- Hsing,L.C., Kirk,E.A., McMillen,T.S., Hsiao,S.H., Caldwell,M., Houston,B., Rudensky,A.Y. and LeBoeuf,R.C. \<br\>Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse\<br\>J Autoimmun (2010) 34, 96-104. PubMed Europe PubMed DOI
- Hu,Y., Morioka,K. and Itoh,Y. \<br\>Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste\<br\>J Sci Food Agric (2010) 90, 370-375. PubMed Europe PubMed DOI
- Kishore Kumar,G.D., Chavarria,G.E., Charlton-Sevcik,A.K., Arispe,W.M., Macdonough,M.T., Strecker,T.E., Chen,S.E., Siim,B.G., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors\<br\>Bioorg Med Chem Lett (2010) 20, 1415-1419. PubMed Europe PubMed DOI I
- Kistler,A.D., Peev,V., Forst,A.L., El Hindi,S., Altintas,M.M. and Reiser,J. \<br\>Enzymatic disease of the podocyte\<br\>Pediatr Nephrol (2010) 25, 1017-1023. PubMed Europe PubMed DOI
- Konjar,S., Sutton,V.R., Hoves,S., Repnik,U., Yagita,H., Reinheckel,T., Peters,C., Turk,V., Turk,B., Trapani,J.A. and Kopitar-Jerala,N. \<br\>Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L\<br\>Immunology (2010) 131, 257-267. PubMed Europe PubMed DOI
- Kumar,G.D., Chavarria,G.E., Charlton-Sevcik,A.K., Yoo,G.K., Song,J., Strecker,T.E., Siim,B.G., Chaplin,D.J., Trawick,M.L. and Pinney,K.G. \<br\>Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L\<br\>Bioorg Med Chem Lett (2010) 20, 6610-6615. PubMed Europe PubMed DOI I
- Lankelma,J.M., Voorend,D.M., Barwari,T., Koetsveld,J., Van der Spek,A.H., De Porto,A.P., Van Rooijen,G. and Van Noorden,C.J. \<br\>Cathepsin L, target in cancer treatment?\<br\>Life Sci (2010) 86, 225-233. PubMed Europe PubMed DOI
- Minokadeh,A., Funkelstein,L., Toneff,T., Hwang,S.R., Beinfeld,M., Reinheckel,T., Peters,C., Zadina,J. and Hook,V. \<br\>Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression\<br\>Mol Cell Neurosci (2010) 43, 98-107. PubMed Europe PubMed DOI K
- Sansanwal,P., Shukla,A.A., Das,T.K. and Chauhan,S.S. \<br\>Truncated human cathepsin L, encoded by a novel splice variant, exhibits altered subcellular localization and cytotoxicity\<br\>Protein Pept Lett (2010) 17, 238-245. PubMed Europe PubMed DOI R
- Sevenich,L., Hagemann,S., Stoeckle,C., Tolosa,E., Peters,C. and Reinheckel,T. \<br\>Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice\<br\>Biochimie (2010) 92, 1674-1680. PubMed Europe PubMed DOI
- Shah,P.P., Wang,T., Kaletsky,R.L., Myers,M.C., Purvis,J.E., Jing,H., Huryn,D.M., Greenbaum,D.C., Smith,A.B., III, Bates,P. and Diamond,S.L. \<br\>A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells\<br\>Mol Pharmacol (2010) 78, 319-324. PubMed Europe PubMed DOI I
- Shimada,N., Ohno-Matsui,K., Iseki,S., Koike,M., Uchiyama,Y., Wang,J., Yoshida,T., Sato,T., Peters,C., Mochizuki,M. and Morita,I. \<br\>Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization\<br\>Am J Pathol (2010) 176, 2571-2580. PubMed Europe PubMed DOI
- Wartmann,T., Mayerle,J., Kahne,T., Sahin-Toth,M., Ruthenburger,M., Matthias,R., Kruse,A., Reinheckel,T., Peters,C., Weiss,F.U., Sendler,M., Lippert,H., Schulz,H.U., Aghdassi,A., Dummer,A., Teller,S., Halangk,W. and Lerch,M.M. \<br\>Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice\<br\>Gastroenterology (2010) 138, 726-737. PubMed Europe PubMed DOI
- Yamada,A., Ishimaru,N., Arakaki,R., Katunuma,N. and Hayashi,Y. \<br\>Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity\<br\>PLoS ONE (2010) 5, e12894. PubMed Europe PubMed DOI PMC EPMC I
- Yamazaki,Y., Kamei,Y., Sugita,S., Akaike,F., Kanai,S., Miura,S., Hirata,Y., Troen,B.R., Kitamura,T., Nishino,I., Suganami,T., Ezaki,O. and Ogawa,Y. \<br\>The cathepsin L gene is a direct target of FOXO1 in skeletal muscle\<br\>Biochem J (2010) 427, 171-178. PubMed Europe PubMed DOI
- Zeeuwen,P.L., van Vlijmen-Willems,I.M., Cheng,T., Rodijk-Olthuis,D., Hitomi,K., Hara-Nishimura,I., John,S., Smyth,N., Reinheckel,T., Hendriks,W.J. and Schalkwijk,J. \<br\>The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea\<br\>FASEB J (2010) 24, 3744-3755. PubMed Europe PubMed DOI K
- Ahimbisibwe,J.B., Inoue,K. and Aoki,T. \<br\>Detection of cathepsin L in red cell membranes from fish blood\<br\>Fish Sci (2009) 76, 155-159. DOI
- Asaad,N., Bethel,P.A., Coulson,M.D., Dawson,J.E., Ford,S.J., Gerhardt,S., Grist,M., Hamlin,G.A., James,M.J., Jones,E.V., Karoutchi,G.I., Kenny,P.W., Morley,A.D., Oldham,K., Rankine,N., Ryan,D., Wells,S.L., Wood,L., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S. \<br\>Dipeptidyl nitrile inhibitors of cathepsin L\<br\>Bioorg Med Chem Lett (2009) 19, 4280-4283. PubMed Europe PubMed DOI I
- Beinfeld,M.C., Funkelstein,L., Foulon,T., Cadel,S., Kitagawa,K., Toneff,T., Reinheckel,T., Peters,C. and Hook,V. \<br\>Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies\<br\>Peptides (2009) 30, 1882-1891. PubMed Europe PubMed DOI PMC EPMC K I
- Bethel,P.A., Gerhardt,S., Jones,E.V., Kenny,P.W., Karoutchi,G.I., Morley,A.D., Oldham,K., Rankine,N., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S. \<br\>Design of selective cathepsin inhibitors\<br\>Bioorg Med Chem Lett (2009) 19, 4622-4625. PubMed Europe PubMed DOI I
- Biswas,N., Rodriguez-Flores,J.L., Courel,M., Gayen,J.R., Vaingankar,S.M., Mahata,M., Torpey,J.W., Taupenot,L., O'Connor,D.T. and Mahata,S.K. \<br\>Cathepsin L colocalizes with chromogranin A in chromaffin vesicles to generate active peptides\<br\>Endocrinology (2009) 150, 3547-3557. PubMed Europe PubMed DOI PMC EPMC
- Fei,X.F., Qin,Z.H., Xiang,B., Li,L.Y., Han,F., Fukunaga,K. and Liang,Z.Q. \<br\>Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine\<br\>Brain Res (2009) 1264, 85-97. PubMed Europe PubMed DOI
- Fonovic,U.P. and Kos,J. \<br\>Efficient removal of cathepsin L from active cathepsin X using immunoprecipitation technique\<br\>Acta Chim Slov (2009) 56, 985-988.
- Jordans,S., Jenko-Kokalj,S., Kuhl,N.M., Tedelind,S., Sendt,W., Bromme,D., Turk,D. and Brix,K. \<br\>Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions\<br\>BMC Biochem (2009) 10, 23. PubMed Europe PubMed DOI PMC EPMC
- Liu,Y., Li,X., Peng,D., Tan,Z., Liu,H., Qing,Y., Xue,Y. and Shi,G.P. \<br\>Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease\<br\>Am J Cardiol (2009) 103, 476-481. PubMed Europe PubMed DOI PMC EPMC
- Luft,F.C. \<br\>From furless to heartless - unraveling the diverse functions of cathepsin L\<br\>J Mol Med (2009) 87, 225-227. PubMed Europe PubMed DOI K
- Rebbaa,A., Chu,F., Sudha,T., Gallati,C., Dier,U., Dyskin,E., Yalcin,M., Bianchini,C., Shaker,O. and Mousa,S.A. \<br\>The anti-angiogenic activity of NSITC, a specific cathepsin L inhibitor\<br\>Anticancer Res (2009) 29, 4473-4481. PubMed Europe PubMed I
- Rebbaa,A., Dyskin,E., Dier,E., Gallati,C., Honko,C., Simone,T., Yalcin,M., Sudha,T. and Mousa,S.A. \<br\>Antiproliferative, antiangiogenesis, and reversal of chemoresistance by specific cathepsin L inhibitors\<br\>J Clin Oncol (2009) 27, e14643. PubMed Europe PubMed I
- Schilling,K., Korner,A., Sehmisch,S., Kreusch,A., Kleint,R., Benedix,Y., Schlabrakowski,A. and Wiederanders,B. \<br\>Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases\<br\>Biol Chem (2009) 390, 167-174. PubMed Europe PubMed DOI
- See,V., Free,P., Cesbron,Y., Nativo,P., Shaheen,U., Rigden,D.J., Spiller,D.G., Fernig,D.G., White,M.R., Prior,I.A., Brust,M., Lounis,B. and Levy,R. \<br\>Cathepsin L digestion of nanobioconjugates upon endocytosis\<br\>ACS Nano (2009) 3, 2461-2468. PubMed Europe PubMed DOI
- Shenoy,R.T., Chowdhury,S.F., Kumar,S., Joseph,L., Purisima,E.O. and Sivaraman,J. \<br\>A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors\<br\>J Med Chem (2009) 52, 6335-6346. PubMed Europe PubMed DOI S I
- Takahashi,K., Ueno,T., Tanida,I., Minematsu-Ikeguchi,N., Murata,M. and Kominami,E. \<br\>Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis\<br\>Biol Pharm Bull (2009) 32, 475-479. PubMed Europe PubMed DOI I
- Tang,Q., Cai,J., Shen,D., Bian,Z., Yan,L., Wang,Y.X., Lan,J., Zhuang,G.Q., Ma,W.Z. and Wang,W. \<br\>Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling\<br\>J Mol Med (2009) 87, 249-260. PubMed Europe PubMed DOI
- Ueno,T. and Takahashi,K. \<br\>A cathepsin L-specific inhibitor preferentially inhibits degradation of autophagosomal LC3 and GABARAP in HeLa and Huh-7 cells\<br\>Autophagy (2009) 5, 878-879. PubMed Europe PubMed I
- Visone,T., Charron,M. and Wright,W.W. \<br\>Activation and repression domains within the promoter of the rat cathepsin L gene orchestrate Sertoli cell-specific and stage-specific gene transcription in transgenic mice\<br\>Biol Reprod (2009) 81, 571-579. PubMed Europe PubMed DOI
- Yoshii,H., Kamiyama,H., Minematsu,K., Goto,K., Mizota,T., Oishi,K., Katunuma,N., Yamamoto,N. and Kubo,Y. \<br\>Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells\<br\>Virology (2009) 394, 227-234. PubMed Europe PubMed DOI I
- Abboud-Jarrous,G., Atzmon,R., Peretz,T., Palermo,C., Gadea,B.B., Joyce,J.A. and Vlodavsky,I. \<br\>Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment\<br\>J Biol Chem (2008) 283, 18167-18176. PubMed Europe PubMed DOI PMC EPMC
- Bosch,B.J., Bartelink,W. and Rottier,P.J. \<br\>Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide\<br\>J Virol (2008) 82, 8887-8890. PubMed Europe PubMed DOI PMC EPMC
- Chowdhury,S.F., Joseph,L., Kumar,S., Tulsidas,S.R., Bhat,S., Ziomek,E., Menard,R., Sivaraman,J. and Purisima,E.O. \<br\>Exploring inhibitor binding at the S' subsites of cathepsin L\<br\>J Med Chem (2008) 51, 1361-1368. PubMed Europe PubMed DOI S I
- Duncan,E.M., Muratore-Schroeder,T.L., Cook,R.G., Garcia,B.A., Shabanowitz,J., Hunt,D.F. and Allis,C.D. \<br\>Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation\<br\>Cell (2008) 135, 284-294. PubMed Europe PubMed DOI PMC EPMC P
- Fairhead,M., Johnson,K.A., Kowatz,T., McMahon,S.A., Carter,L.G., Oke,M., Liu,H., Naismith,J.H. and van der Walle,C.F. \<br\>Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras\<br\>Chem Commun (Camb) (2008) 2008, 1765-1767. PubMed Europe PubMed DOI S
- Fairhead,M. and van der Walle,C.F. \<br\>The heavy-light chain loop of human cathepsin-L modulates its activity and stability\<br\>Protein Pept Lett (2008) 15, 47-53. PubMed Europe PubMed DOI
- Fairhead,M., Kelly,S.M. and van der Walle,C.F. \<br\>A heparin binding motif on the pro-domain of human procathepsin L mediates zymogen destabilization and activation\<br\>Biochem Biophys Res Commun (2008) 366, 862-867. PubMed Europe PubMed DOI
- Funkelstein,L., Toneff,T., Hwang,S.R., Reinheckel,T., Peters,C. and Hook,V. \<br\>Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression\<br\>J Neurochem (2008) 106, 384-391. PubMed Europe PubMed DOI PMC EPMC K
- Funkelstein,L., Toneff,T., Mosier,C., Hwang,S.R., Beuschlein,F., Lichtenauer,U.D., Reinheckel,T., Peters,C. and Hook,V. \<br\>Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression\<br\>J Biol Chem (2008) 283, 35652-35659. PubMed Europe PubMed DOI PMC EPMC I
- Hook,V., Funkelstein,L., Lu,D., Bark,S., Wegrzyn,J. and Hwang,S.R. \<br\>Proteases for processing proneuropeptides into peptide neurotransmitters and hormones\<br\>Annu Rev Pharmacol Toxicol (2008) 48, 393-423. PubMed Europe PubMed DOI PMC EPMC
- Jean,D., Rousselet,N. and Frade,R. \<br\>Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region\<br\>Biochem J (2008) 413, 125-134. PubMed Europe PubMed DOI
- Myers,M.C., Shah,P.P., Diamond,S.L., Huryn,D.M. and Smith,A.B., III \<br\>Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor\<br\>Bioorg Med Chem Lett (2008) 18, 210-214. PubMed Europe PubMed DOI PMC EPMC I
- Myers,M.C., Shah,P.P., Beavers,M.P., Napper,A.D., Diamond,S.L., Smith,A.B., III and Huryn,D.M. \<br\>Design, synthesis, and evaluation of inhibitors of cathepsin L: exploiting a unique thiocarbazate chemotype\<br\>Bioorg Med Chem Lett (2008) 18, 3646-3651. PubMed Europe PubMed DOI PMC EPMC I
- Schaschke,N., Assfalg-Machleidt,I. and Machleidt,W. \<br\>Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions\<br\>Chembiochem (2008) 9, 1721-1724. PubMed Europe PubMed DOI I
- Shah,P.P., Myers,M.C., Beavers,M.P., Purvis,J.E., Jing,H., Grieser,H.J., Sharlow,E.R., Napper,A.D., Huryn,D.M., Cooperman,B.S., Smith,A.B., III and Diamond,S.L. \<br\>Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L\<br\>Mol Pharmacol (2008) 74, 34-41. PubMed Europe PubMed DOI PMC EPMC S I
- Yadav,M.R., Shinde,A.K., Chouhan,B.S., Giridhar,R. and Menard,R. \<br\>Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors\<br\>J Enzyme Inhib Med Chem (2008) 23, 190-197. PubMed Europe PubMed DOI I
- Zhu,S., Wei,L., Yamasaki,K. and Gallo,R.L. \<br\>Activation of cathepsin L by the cathelin-like domain of protegrin-3\<br\>Mol Immunol (2008) 45, 2531-2536. PubMed Europe PubMed DOI PMC EPMC
- Boudreau,F., Lussier,C.R., Mongrain,S., Darsigny,M., Drouin,J.L., Doyon,G., Suh,E.R., Beaulieu,J.F., Rivard,N. and Perreault,N. \<br\>Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia\<br\>FASEB J (2007) 21, 3853-3865. PubMed Europe PubMed DOI K
- Burden,R.E., Snoddy,P., Jefferies,C.A., Walker,B. and Scott,C.J. \<br\>Inhibition of cathepsin L-like proteases by cathepsin V propeptide\<br\>Biol Chem (2007) 388, 541-545. PubMed Europe PubMed DOI
- Charron,M., Chern,J.Y. and Wright,W.W. \<br\>The cathepsin L first intron stimulates gene expression in rat Sertoli cells\<br\>Biol Reprod (2007) 76, 813-824. PubMed Europe PubMed DOI
- Goulet,B., Sansregret,L., Leduy,L., Bogyo,M., Weber,E., Chauhan,S.S. and Nepveu,A. \<br\>Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation\<br\>Mol Cancer Res (2007) 5, 899-907. PubMed Europe PubMed DOI
- Hwang,S.R., Garza,C., Mosier,C., Toneff,T., Wunderlich,E., Goldsmith,P. and Hook,V. \<br\>Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion\<br\>J Biol Chem (2007) 282, 9556-9563. PubMed Europe PubMed DOI
- Kramer,G., Paul,A., Kreusch,A., Schuler,S., Wiederanders,B. and Schilling,K. \<br\>Optimized folding and activation of recombinant procathepsin L and S produced in Escherichia coli\<br\>Protein Expr Purif (2007) 54, 147-156. PubMed Europe PubMed DOI E
- Mori,Y., Yamashita,T., Tanaka,Y., Tsuda,Y., Abe,T., Moriishi,K. and Matsuura,Y. \<br\>Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells\<br\>J Virol (2007) 81, 8477-8487. PubMed Europe PubMed DOI PMC EPMC
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- Sever,S., Altintas,M.M., Nankoe,S.R., Moller,C.C., Ko,D., Wei,C., Henderson,J., del Re,E.C., Hsing,L., Erickson,A., Cohen,C.D., Kretzler,M., Kerjaschki,D., Rudensky,A., Nikolic,B. and Reiser,J. \<br\>Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease\<br\>J Clin Invest (2007) 117, 2095-2104. PubMed Europe PubMed DOI PMC EPMC
- Spira,D., Stypmann,J., Tobin,D.J., Petermann,I., Mayer,C., Hagemann,S., Vasiljeva,O., Gunther,T., Schule,R., Peters,C. and Reinheckel,T. \<br\>Cell type-specific functions of the lysosomal protease cathepsin L in the heart\<br\>J Biol Chem (2007) 282, 37045-37052. PubMed Europe PubMed DOI
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- Tingaud-Sequeira,A. and Cerda,J. \<br\>Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme\<br\>Gene (2007) 386, 98-106. PubMed Europe PubMed DOI
- Walz,M., Kellermann,S., Bylaite,M., Andree,B., Ruther,U., Paus,R., Kloepper,J.E., Reifenberger,J. and Ruzicka,T. \<br\>Expression of the human cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis\<br\>Exp Dermatol (2007) 16, 715-723. PubMed Europe PubMed DOI
- Yang,M., Zhang,Y., Pan,J., Sun,J., Liu,J., Libby,P., Sukhova,G.K., Doria,A., Katunuma,N., Peroni,O.D., Guerre-Millo,M., Kahn,B.B., Clement,K. and Shi,G.P. \<br\>Cathepsin L activity controls adipogenesis and glucose tolerance\<br\>Nat Cell Biol (2007) 9, 970-977. PubMed Europe PubMed DOI K I
- Yang,Z. and Cox,J.L. \<br\>Cathepsin L increases invasion and migration of B16 melanoma\<br\>Cancer Cell Int (2007) 7, 8. PubMed Europe PubMed DOI PMC EPMC
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- Bulynko,Y.A., Hsing,L.C., Mason,R.W., Tremethick,D.J. and Grigoryev,S.A. \<br\>Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin\<br\>Mol Cell Biol (2006) 26, 4172-4184. PubMed Europe PubMed DOI PMC EPMC
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- [YEAR:24-3-2006]Cheng,T., Hitomi,K., van Vlijmen-Willems,I.M., de Jongh,G.J., Yamamoto,K., Nishi,K., Watts,C., Reinheckel,T., Schalkwijk,J. and Zeeuwen,P.L. \<br\>Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification\<br\>J Biol Chem (24-3-2006) 281, 15893-15899. PubMed Europe PubMed DOI
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- Goulet,B., Truscott,M. and Nepveu,A. \<br\>A novel proteolytically processed CDP/Cux isoform of 90 kDa is generated by cathepsin L\<br\>Biol Chem (2006) 387, 1285-1293. PubMed Europe PubMed DOI
- Hashimoto,Y., Kondo,C., Kojima,T., Nagata,H., Moriyama,A., Hayakawa,T. and Katunuma,N. \<br\>Significance of 32-kDa cathepsin L secreted from cancer cells\<br\>Cancer Biother Radiopharm (2006) 21, 217-224. PubMed Europe PubMed DOI
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- Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D. \<br\>Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins\<br\>Biol Chem (2006) 387, 1295-1303. PubMed Europe PubMed DOI P
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- [YEAR:24-6-2006]Liu,J., Sukhova,G.K., Yang,J.T., Sun,J., Ma,L., Ren,A., Xu,W.H., Fu,H., Dolganov,G.M., Hu,C., Libby,P. and Shi,G.P. \<br\>Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells\<br\>Atherosclerosis (24-6-2006) 184, 302-311. PubMed Europe PubMed DOI
- Petermann,I., Mayer,C., Stypmann,J., Biniossek,M.L., Tobin,D.J., Engelen,M.A., Dandekar,T., Grune,T., Schild,L., Peters,C. and Reinheckel,T. \<br\>Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice\<br\>FASEB J (2006) 20, 1266-1268. PubMed Europe PubMed DOI K
- Ruttger,A., Mollenhauer,J., Loser,R., Gutschow,M. and Wiederanders,B. \<br\>Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide\<br\>Biotechniques (2006) 41, 469-473. PubMed Europe PubMed DOI A
- Sevenich,L., Pennacchio,L.A., Peters,C. and Reinheckel,T. \<br\>Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice\<br\>Biol Chem (2006) 387, 885-891. PubMed Europe PubMed DOI K
- [YEAR:25-8-2006]Vicik,R., Busemann,M., Gelhaus,C., Stiefl,N., Scheiber,J., Schmitz,W., Schulz,F., Mladenovic,M., Engels,B., Leippe,M., Baumann,K. and Schirmeister,T. \<br\>Aziridide-based inhibitors of cathepsin L: synthesis, inhibition activity, and docking studies\<br\>ChemMedChem (25-8-2006) 1, 1126-1141. PubMed Europe PubMed DOI I
- Zajc,I., Hreljac,I. and Lah,T. \<br\>Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics\<br\>Anticancer Res (2006) 26, 3357-3364. PubMed Europe PubMed
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- Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y. \<br\>Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)\<br\>Am J Pathol (2005) 167, 1713-1728. PubMed Europe PubMed DOI PMC EPMC K
- [YEAR:1-10-2005]Maehr,R., Mintern,J.D., Herman,A.E., Lennon-Dumenil,A.M., Mathis,D., Benoist,C. and Ploegh,H.L. \<br\>Cathepsin L is essential for onset of autoimmune diabetes in NOD mice\<br\>J Clin Invest (1-10-2005) 115, 2934-2943. PubMed Europe PubMed DOI PMC EPMC
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- Nishinaka,T., Song,J., Lum,K. and Chiu,R. \<br\>Molecular cloning of cDNA for SPase, a monkey cathepsin L orthologue\<br\>DNA Seq (2005) 16, 147-150. PubMed Europe PubMed DOI
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- Puzer,L., Vercesi,J., Alves,M.F., Barros,N.M., Araujo,M.S., Aparecida Juliano,M., Reis,M.L., Juliano,L. and Carmona,A.K. \<br\>A possible alternative mechanism of kinin generation in vivo by cathepsin L\<br\>Biol Chem (2005) 386, 699-704. PubMed Europe PubMed DOI
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- Rocken,C., Menard,R., Buhling,F., Vockler,S., Raynes,J., Stix,B., Kruger,S., Roessner,A. and Kahne,T. \<br\>Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation\<br\>Ann Rheum Dis (2005) 64, 808-815. PubMed Europe PubMed DOI PMC EPMC
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- Urbich,C., Heeschen,C., Aicher,A., Sasaki,K., Bruhl,T., Farhadi,M.R., Vajkoczy,P., Hofmann,W.K., Peters,C., Pennacchio,L.A., Abolmaali,N.D., Chavakis,E., Reinheckel,T., Zeiher,A.M. and Dimmeler,S. \<br\>Cathepsin L is required for endothelial progenitor cell-induced neovascularization\<br\>Nat Med (2005) 11, 206-213. PubMed Europe PubMed DOI
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- Collette,J., Bocock,J.P., Ahn,K., Chapman,R.L., Godbold,G., Yeyeodu,S. and Erickson,A.H. \<br\>Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L\<br\>Int Rev Cytol (2004) 241, 1-51. PubMed Europe PubMed DOI
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- Hook,V., Yasothornsrikul,S., Greenbaum,D., Medzihradszky,K.F., Troutner,K., Toneff,T., Bundey,R., Logrinova,A., Reinheckel,T., Peters,C. and Bogyo,M. \<br\>Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones\<br\>Biol Chem (2004) 385, 473-480. PubMed Europe PubMed DOI
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- Hu,K.J. and Leung,P.C. \<br\>Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte\<br\>Comp Biochem Physiol B Biochem Mol Biol (2004) 137, 21-33. PubMed Europe PubMed DOI
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- Onishi,K., Li,Y., Ishii,K., Hisaeda,H., Tang,L., Duan,X., Dainichi,T., Maekawa,Y., Katunuma,N. and Himeno,K. \<br\>Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection\<br\>Microbes Infect (2004) 6, 468-474. PubMed Europe PubMed DOI I
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- [YEAR:1-1-2004]Rousselet,N., Mills,L., Jean,D., Tellez,C., Bar-Eli,M. and Frade,R. \<br\>Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment\<br\>Cancer Res (1-1-2004) 64, 146-151. PubMed Europe PubMed DOI
- Schedel,J., Seemayer,C.A., Pap,T., Neidhart,M., Kuchen,S., Michel,B.A., Gay,R.E., Muller-Ladner,U., Gay,S. and Zacharias,W. \<br\>Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis\<br\>Gene Ther (2004) 11, 1040-1047. PubMed Europe PubMed DOI
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- Wille,A., Gerber,A., Heimburg,A., Reisenauer,A., Peters,C., Saftig,P., Reinheckel,T., Welte,T. and Buhling,F. \<br\>Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells\<br\>Biol Chem (2004) 385, 665-670. PubMed Europe PubMed DOI
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- Charron,M., Folmer,J.S. and Wright,W.W. \<br\>A 3-kilobase region derived from the rat cathepsin L gene directs in vivo expression of a reporter gene in sertoli cells in a manner comparable to that of the endogenous gene\<br\>Biol Reprod (2003) 68, 1641-1648. PubMed Europe PubMed DOI
- Charron,M., DeCerbo,J.N. and Wright,W.W. \<br\>A GC-box within the proximal promoter region of the rat cathepsin L gene activates transcription in Sertoli cells of sexually mature rats\<br\>Biol Reprod (2003) 68, 1649-1656. PubMed Europe PubMed DOI
- Desmazes,C., Galineau,L., Gauthier,F., Bromme,D. and Lalmanach,G. \<br\>Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L\<br\>Eur J Biochem (2003) 270, 171-178. PubMed Europe PubMed DOI
- Levicar,N., Dewey,R.A., Daley,E., Bates,T.E., Davies,D., Kos,J., Pilkington,G.J. and Lah,T.T. \<br\>Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis\<br\>Cancer Gene Ther (2003) 10, 141-151. PubMed Europe PubMed DOI K
- [YEAR:26-6-2003]Ohashi,K., Naruto,M., Nakaki,T. and Sano,E. \<br\>Identification of interleukin-8 converting enzyme as cathepsin L\<br\>Biochim Biophys Acta (26-6-2003) 1649, 30-39. PubMed Europe PubMed DOI
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- [YEAR:24-6-2003]Welss,T., Sun,J., Irving,J.A., Blum,R., Smith,A.I., Whisstock,J.C., Pike,R.N., von Mikecz,A., Ruzicka,T., Bird,P.I. and Abts,H.F. \<br\>Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis\<br\>Biochemistry (24-6-2003) 42, 7381-7389. PubMed Europe PubMed DOI
- Wright,W.W., Smith,L., Kerr,C. and Charron,M. \<br\>Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis\<br\>Biol Reprod (2003) 68, 680-687. PubMed Europe PubMed DOI
- [YEAR:5-8-2003]Yasothornsrikul,S., Greenbaum,D., Medzihradszky,K.F., Toneff,T., Bundey,R., Miller,R., Schilling,B., Petermann,I., Dehnert,J., Logvinova,A., Goldsmith,P., Neveu,J.M., Lane,W.S., Gibson,B., Reinheckel,T., Peters,C., Bogyo,M. and Hook,V. \<br\>Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter\<br\>Proc Natl Acad Sci U S A (5-8-2003) 100, 9590-9595. PubMed Europe PubMed DOI PMC EPMC
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- Benavides,F., Starost,M.F., Flores,M., Gimenez-Conti,I.B., Guenet,J.L. and Conti,C.J. \<br\>Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation\<br\>Am J Pathol (2002) 161, 693-703. PubMed Europe PubMed DOI PMC EPMC K M
- [YEAR:21-11-2002]Chowdhury,S.F., Sivaraman,J., Wang,J., Devanathan,G., Lachance,P., Qi,H., Menard,R., Lefebvre,J., Konishi,Y., Cygler,M., Sulea,T. and Purisima,E.O. \<br\>Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides\<br\>J Med Chem (21-11-2002) 45, 5321-5329. PubMed Europe PubMed DOI S I
- [YEAR:5-7-2002]Ebert,D.H., Deussing,J., Peters,C. and Dermody,T.S. \<br\>Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells\<br\>J Biol Chem (5-7-2002) 277, 24609-24617. PubMed Europe PubMed DOI
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- [YEAR:4-11-2002]Fiebiger,E., Maehr,R., Villadangos,J., Weber,E., Erickson,A., Bikoff,E., Ploegh,H.L. and Lennon-Dumenil,A.M. \<br\>Invariant chain controls the activity of extracellular cathepsin L\<br\>J Exp Med (4-11-2002) 196, 1263-1269. PubMed Europe PubMed DOI PMC EPMC
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- Nishimura,F., Naruishi,H., Naruishi,K., Yamada,T., Sasaki,J., Peters,C., Uchiyama,Y. and Murayama,Y. \<br\>Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice\<br\>Am J Pathol (2002) 161, 2047-2052. PubMed Europe PubMed DOI PMC EPMC
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- Tobin,D.J., Foitzik,K., Reinheckel,T., Mecklenburg,L., Botchkarev,V.A., Peters,C. and Paus,R. \<br\>The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling\<br\>Am J Pathol (2002) 160, 1807-1821. PubMed Europe PubMed DOI PMC EPMC
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- Abudula,A., Rommerskirch,W., Weber,E., Gunther,D. and Wiederanders,B. \<br\>Splice variants of human cathepsin L mRNA show different expression rates\<br\>Biol Chem (2001) 382, 1583-1591. PubMed Europe PubMed DOI R
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- Benavides,F., Venables,A., Poetschke Klug,H., Glasscock,E., Rudensky,A., Gomez,M., Martin Palenzuela,N., Guenet,J.L., Richie,E.R. and Conti,C.J. \<br\>The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (Ctsl) gene\<br\>Immunogenetics (2001) 53, 233-242. PubMed Europe PubMed DOI
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- Krueger,S., Kellner,U., Buehling,F. and Roessner,A. \<br\>Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype\<br\>Cancer Gene Ther (2001) 8, 522-528. PubMed Europe PubMed DOI
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- Roth,W., Deussing,J., Botchkarev,V.A., Pauly-Evers,M., Saftig,P., Hafner,A., Schmidt,P., Schmahl,W., Scherer,J., Anton-Lamprecht,I., von Figura,K., Paus,R. and Peters,C. \<br\>Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling\<br\>FASEB J (2000) 14, 2075-2086. PubMed Europe PubMed DOI K M
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- Hook,V.Y., Tezapsidis,N., Hwang,S.R., Sei,C., Byrne,M. and Yasothornsrikul,S. \<br\>alpha1-Antichymotrypsin-like proteins I and II purified from bovine adrenal medulla are enriched in chromaffin granules and inhibit the proenkephalin processing enzyme "prohormone thiol protease"\<br\>J Neurochem (1999) 73, 59-69. PubMed Europe PubMed DOI
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- McDonald,J.K. and Emerick,J.M. \<br\>Purification and characterization of procathepsin L, a self-processing zymogen of guinea pig spermatozoa that acts on a cathepsin D assay substrate\<br\>Arch Biochem Biophys (1995) 323, 409-422. PubMed Europe PubMed DOI A
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- Kane,S.E. \<br\>Mouse procathepsin L lacking a functional glycosylation site is properly folded, stable, and secreted by NIH 3T3 cells\<br\>J Biol Chem (1993) 268, 11456-11462. PubMed Europe PubMed
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