Literature for peptidase M50.001: site 2 peptidase
(Topics flags: M Mutation, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)
- Lim,P.J., Marcionelli,G., Srikanthan,P., Ndarugendamwo,T., Pinner,J., Rohrbach,M. and Giunta,C. \<br\>Perturbations in fatty acid metabolism and collagen production infer pathogenicity of a novel MBTPS2 variant in Osteogenesis imperfecta\<br\>Front Endocrinol (Lausanne) (2023) 14, 1195704. PubMed Europe PubMed DOI PMC EPMC
- Caengprasath,N., Theerapanon,T., Porntaveetus,T. and Shotelersuk,V. \<br\>MBTPS2, a membrane bound protease, underlying several distinct skin and bone disorders\<br\>J Transl Med (2021) 19, 114. PubMed Europe PubMed DOI PMC EPMC V
- Danyukova,T., Schoneck,K. and Pohl,S. \<br\>Site-1 and site-2 proteases: A team of two in regulated proteolysis\<br\>Biochim Biophys Acta (2021) 1869, 119138. PubMed Europe PubMed DOI V
- Lim,P.J., Marfurt,S., Lindert,U., Opitz,L., Ndarugendamwo,T., Srikanthan,P., Poms,M., Hersberger,M., Langhans,C.D., Haas,D., Rohrbach,M. and Giunta,C. \<br\>Omics Profiling of S2P Mutant Fibroblasts as a Mean to Unravel the Pathomechanism and Molecular Signatures of X-Linked MBTPS2 Osteogenesis Imperfecta\<br\>Front Genet (2021) 12, 662751. PubMed Europe PubMed DOI PMC EPMC
- Strong,A., March,M.E., Cardinale,C.J., Kim,S.E., Merves,J., Whitworth,H., Raffini,L., Larosa,C., Copelovitch,L., Hou,C., Slater,D., Vaccaro,C., Watson,D., Zackai,E.H., Billheimer,J. and Hakonarson,H. \<br\>A novel MBTPS2 variant associated with BRESHECK syndrome impairs sterol-regulated transcription and the endoplasmic reticulum stress response\<br\>Am J Med Genet A (2021) PubMed Europe PubMed DOI
- Liu,Y., Xu,D., Wang,L., Du,W., Zhang,L. and Xiang,X. \<br\>MBTPS2 exacerbates albuminuria in streptozotocin-induced type I diabetic nephropathy by promoting endoplasmic reticulum stress-mediated renal damage\<br\>Arch Physiol Biochem (2020) 1-8. PubMed Europe PubMed DOI
- Xiao,J., Xiong,Y., Yang,L.T., Wang,J.Q., Zhou,Z.M., Dong,L.W., Shi,X.J., Zhao,X., Luo,J. and Song,B.L. \<br\>POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation\<br\>Protein Cell (2020) PubMed Europe PubMed DOI
- Lindert,U., Cabral,W.A., Ausavarat,S., Tongkobpetch,S., Ludin,K., Barnes,A.M., Yeetong,P., Weis,M., Krabichler,B., Srichomthong,C., Makareeva,E.N., Janecke,A.R., Leikin,S., Rothlisberger,B., Rohrbach,M., Kennerknecht,I., Eyre,D.R., Suphapeetiporn,K., Giunta,C., Marini,J.C. and Shotelersuk,V. \<br\>MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta\<br\>Nat Commun (2016) 7, 11920. PubMed Europe PubMed DOI PMC EPMC M
- Guan,M., Su,L., Yuan,Y.C., Li,H. and Chow,W.A. \<br\>Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer\<br\>Sci Rep (2015) 5, 9698. PubMed Europe PubMed DOI I
- Zhou,S.F., Sun,L., Valdes,A.E., Engstrom,P., Song,Z.T., Lu,S.J. and Liu,J.X. \<br\>Membrane-associated transcription factor peptidase, site-2 protease, antagonizes ABA signaling in Arabidopsis\<br\>New Phytol (2015) 208, 188-197. PubMed Europe PubMed DOI
- Bornholdt,D., Atkinson,T.P., Bouadjar,B., Catteau,B., Cox,H., De Silva,D., Fischer,J., Gunasekera,C.N., Hadj-Rabia,S., Happle,R., Holder-Espinasse,M., Kaminski,E., Konig,A., Megarbane,A., Megarbane,H., Neidel,U., Oeffner,F., Oji,V., Theos,A., Traupe,H., Vahlquist,A., van Bon,B.W., Virtanen,M. and Grzeschik,K.H. \<br\>Genotype-phenotype correlations emerging from the identification of missense mutations in MBTPS2\<br\>Hum Mutat (2013) 34, 587-594. PubMed Europe PubMed DOI M
- Kroos,L. and Akiyama,Y. \<br\>Biochemical and structural insights into intramembrane metalloprotease mechanisms\<br\>Biochim Biophys Acta (2013) 1828, 2873-2885. PubMed Europe PubMed DOI PMC EPMC V
- Morohashi,Y. and Tomita,T. \<br\>Protein trafficking and maturation regulate intramembrane proteolysis\<br\>Biochim Biophys Acta (2013) 1828, 2855-2861. PubMed Europe PubMed DOI V
- Rawson,R.B. \<br\>The site-2 protease\<br\>Biochim Biophys Acta (2013) 1828, 2801-2807. PubMed Europe PubMed DOI V
- Urban,S. \<br\>Mechanisms and cellular functions of intramembrane proteases\<br\>Biochim Biophys Acta (2013) 1828, 2797-2800. PubMed Europe PubMed DOI V
- Denard,B., Lee,C. and Ye,J. \<br\>Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1\<br\>elife (2012) 1, e00090. PubMed Europe PubMed DOI PMC EPMC
- Rawson,R.B. \<br\>S2P protease\<br\>[ISSN:978-0-12-407743-0] (2012) 3, 1536-1541. DOI
- Oeffner,F., Martinez,F., Schaffer,J., Salhi,A., Monfort,S., Oltra,S., Neidel,U., Bornholdt,D., van Bon,B., Konig,A., Happle,R. and Grzeschik,K.H. \<br\>Intronic mutations affecting splicing of MBTPS2 cause ichthyosis follicularis, alopecia and photophobia (IFAP) syndrome\<br\>Exp Dermatol (2011) 20, 447-449. PubMed Europe PubMed DOI M
- Ozdemir,C. and Rawson,R.B. \<br\>Other ways to skin a cat: activating SREBP without scap\<br\>Fly (Austin) (2011) 5, 3-6. PubMed Europe PubMed M V
- Aten,E., Brasz,L.C., Bornholdt,D., Hooijkaas,I.B., Porteous,M.E., Sybert,V.P., Vermeer,M.H., Vossen,R.H., van der Wielen,M.J., Bakker,E., Breuning,M.H., Grzeschik,K.H., Oosterwijk,J.C. and den Dunnen,J.T. \<br\>Keratosis follicularis spinulosa decalvans is caused by mutations in MBTPS2\<br\>Hum Mutat (2010) 31, 1125-1133. PubMed Europe PubMed DOI M
- Chen,G. and Zhang,X. \<br\>New insights into S2P signaling cascades: regulation, variation, and conservation\<br\>Protein Sci (2010) 19, 2015-2030. PubMed Europe PubMed DOI V
- Eleveld-Trancikova,D., Sanecka,A., van Hout-Kuijer,M.A., Looman,M.W., Hendriks,I.A., Jansen,B.J. and Adema,G.J. \<br\>DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation\<br\>Mol Immunol (2010) 47, 1963-1973. PubMed Europe PubMed DOI
- Ha,Y. \<br\>Structure and mechanism of intramembrane protease\<br\>Semin Cell Dev Biol (2009) 20, 240-250. PubMed Europe PubMed DOI PMC EPMC V
- Oeffner,F., Fischer,G., Happle,R., Konig,A., Betz,R.C., Bornholdt,D., Neidel,U., Boente,M., Redler,S., Romero-Gomez,J., Salhi,A., Vera-Casano,A., Weirich,C. and Grzeschik,K.H. \<br\>IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response\<br\>Am J Hum Genet (2009) 84, 459-467. PubMed Europe PubMed DOI PMC EPMC M
- Wolfe,M.S. \<br\>Intramembrane-cleaving proteases\<br\>J Biol Chem (2009) 284, 13969-13973. PubMed Europe PubMed DOI PMC EPMC
- Murakami,T., Kondo,S., Ogata,M., Kanemoto,S., Saito,A., Wanaka,A. and Imaizumi,K. \<br\>Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress\<br\>J Neurochem (2006) 96, 1090-1100. PubMed Europe PubMed DOI
- Nadanaka,S., Yoshida,H., Sato,R. and Mori,K. \<br\>Analysis of ATF6 activation in site-2 protease-deficient Chinese hamster ovary cells\<br\>Cell Struct Funct (2006) 31, 109-116. PubMed Europe PubMed DOI K
- Rawson,R.B. \<br\>S2P protease\<br\>[ISSN:0-12-079610-4] (2004) 2, 985-988. V
- [YEAR:6-8-2004]Shen,J. and Prywes,R. \<br\>Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6\<br\>J Biol Chem (6-8-2004) 279, 43046-43051. PubMed Europe PubMed DOI
- Okada,T., Haze,K., Nadanaka,S., Yoshida,H., Seidah,N.G., Hirano,Y., Sato,R., Negishi,M. and Mori,K. \<br\>A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6\<br\>J Biol Chem (2003) 278, 31024-31032. PubMed Europe PubMed DOI I
- Weihofen,A. and Martoglio,B. \<br\>Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides\<br\>Trends Cell Biol (2003) 13, 71-78. PubMed Europe PubMed DOI
- [YEAR:15-1-2002]Goldstein,J.L., Rawson,R.B. and Brown,M.S. \<br\>Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis\<br\>Arch Biochem Biophys (15-1-2002) 397, 139-148. PubMed Europe PubMed DOI
- [YEAR:15-2-2002]Lee,K., Tirasophon,W., Shen,X., Michalak,M., Prywes,R., Okada,T., Yoshida,H., Mori,K. and Kaufman,R.J. \<br\>IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response\<br\>Genes Dev (15-2-2002) 16, 452-466. PubMed Europe PubMed DOI PMC EPMC
- Ye,J., Rawson,R.B., Komuro,R., Chen,X., Dave,U.P., Prywes,R., Brown,M.S. and Goldstein,J.L. \<br\>ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs\<br\>Mol Cell (2000) 6, 1355-1364. PubMed Europe PubMed DOI
- [YEAR:9-5-2000]Ye,J., Dave,U.P., Grishin,N.V., Goldstein,J.L. and Brown,M.S. \<br\>Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease\<br\>Proc Natl Acad Sci U S A (9-5-2000) 97, 5123-5128. PubMed Europe PubMed PMC EPMC
- [YEAR:28-9-1999]Brown,M.S. and Goldstein,J.L. \<br\>A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood\<br\>Proc Natl Acad Sci U S A (28-9-1999) 96, 11041-11048. PubMed Europe PubMed DOI PMC EPMC
- Lewis,A.P. and Thomas,P.J. \<br\>A novel clan of zinc metallopeptidases with possible intramembrane cleavage properties\<br\>Protein Sci (1999) 8, 439-442. PubMed Europe PubMed DOI PMC EPMC
- [YEAR:21-12-1999]Rudner,D.Z., Fawcett,P. and Losick,R. \<br\>A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors\<br\>Proc Natl Acad Sci U S A (21-12-1999) 96, 14765-14770. PubMed Europe PubMed DOI PMC EPMC
- [YEAR:30-7-1999]Zelenski,N.G., Rawson,R.B., Brown,M.S. and Goldstein,J.L. \<br\>Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins\<br\>J Biol Chem (30-7-1999) 274, 21973-21980. PubMed Europe PubMed DOI
- [YEAR:10-7-1998]Duncan,E.A., Dave,U.P., Sakai,J., Goldstein,J.L. and Brown,M.S. \<br\>Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning\<br\>J Biol Chem (10-7-1998) 273, 17801-17809. PubMed Europe PubMed DOI
- [YEAR:15-5-1998]Manni,M.E., Cescato,R. and Paganetti,P.A. \<br\>Lack of beta-amyloid production in M19 cells deficient in site 2 processing of the sterol regulatory element binding proteins\<br\>FEBS Lett (15-5-1998) 427, 367-370. PubMed Europe PubMed DOI
- [YEAR:19-6-1998]Ross,S.L., Martin,F., Simonet,L., Jacobsen,F., Deshpande,R., Vassar,R., Bennett,B., Luo,Y., Wooden,S., Hu,S., Citron,M. and Burgess,T.L. \<br\>Amyloid precursor protein processing in sterol regulatory element-binding protein site 2 protease-deficient Chinese hamster ovary cells\<br\>J Biol Chem (19-6-1998) 273, 15309-15312. PubMed Europe PubMed DOI
- [YEAR:30-3-1998]Tomita,T., Chang,T.Y., Kodama,T. and Iwatsubo,T. \<br\>BetaAPP gamma-secretase and SREBP site 2 protease are two different enzymes\<br\>Neuroreport (30-3-1998) 9, 911-913. PubMed Europe PubMed
- Brown,M.S. and Goldstein,J.L. \<br\>The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor\<br\>Cell (1997) 89, 331-340. PubMed Europe PubMed DOI
- Duncan,E.A., Brown,M.S., Goldstein,J.L. and Sakai,J. \<br\>Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2\<br\>J Biol Chem (1997) 272, 12778-12785. PubMed Europe PubMed DOI
- Rawson,R.B., Zelenski,N.G., Nijhawan,D., Ye,J., Sakai,J., Hasan,M.T., Chang,T.Y., Brown,M.S. and Goldstein,J.L. \<br\>Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs\<br\>Mol Cell (1997) 1, 47-57. PubMed Europe PubMed
- [YEAR:28-6-1996]Sakai,J., Duncan,E.A., Rawson,R.B., Hua,X., Brown,M.S. and Goldstein,J.L. \<br\>Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment\<br\>Cell (28-6-1996) 85, 1037-1046. PubMed Europe PubMed DOI
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