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Structure for peptidase S01.153: elastase-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1ELC Sus scrofa 1.75 Å complex with trifluoroacetyl-L-Phe-P-isopropylanilide
Catalytic residues are shown in ball-and-stick representation: His71 in purple, Asp119 in pink and Ser214 in orange. The structural calcium ion is shown as a yellow CPK sphere. Bound inhibitor is shown in grey in ball-and-stick representation.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Salmo salar
mature  peptidase 1.61 Å 1ELT 1ELT 1ELT 1ELT 1ELT 1ELT Berglund et al., 1995
Sus scrofa
complex with peptidyl-pentafluoroethyl ketone MDL 101,146 1.80 Å 1B0E 1B0E 1B0E 1B0E 1B0E 1B0E Cregge et al., 1998
complex with benzyl methyl aminimide inhibitor 1.80 Å 1BMA 1BMA 1BMA 1BMA 1BMA 1BMA Peisach et al., 1995
complex with MDL 101,146 1.80 Å 1BOE 1BOE 1BOE 1BOE 1BOE 1BOE Kalus et al., 1998
complex with 3S,4R-1-toluenesulphonyl-3-ethyl-azetidin-2-one-4-carboxylic acid 1.65 Å 1BTU 1BTU 1BTU 1BTU 1BTU 1BTU Wilmouth et al., 1998
under xenon pressure 2.20 Å 1C1M 1C1M 1C1M 1C1M 1C1M 1C1M Prange et al., 1998
complex with (3S,4S)N-para-toluenesulphonyl-3-ethyl-4-(carboxylic acid) pyrrolidin-2-one at pH 9 1.80 Å 1E34 1E34 1E34 1E34 1E34 1E34 Wright et al., 2000
complex with (3S,4S)N-para-toluenesulphonyl-3-ethyl-4-(carboxylic acid) pyrrolidin-2-one at pH 9 1.90 Å 1E35 1E35 1E35 1E35 1E35 1E35 Wright et al., 2000
complex with (3S,4S)N-para-nitobenzenesulphonyl-3-ethyl-4-(carboxylic acid) pyrrolidin-2-one 1.80 Å 1E36 1E36 1E36 1E36 1E36 1E36 Wright et al., 2000
complex with (3S,4S)N-para-nitobenzenesulphonyl-3-ethyl-4-(carboxylic acid) pyrrolidin-2-one 1.75 Å 1E37 1E37 1E37 1E37 1E37 1E37 Wright et al., 2000
complex with (3S,4S)N-para-nitobenzenesulphonyl-3-ethyl-4-(carboxylic acid) pyrrolidin-2-one 1.70 Å 1E38 1E38 1E38 1E38 1E38 1E38 Wright et al., 2000
complex with Ascaris chymotrpsin/elastase inhibitor 1.65 Å 1EAI 1EAI 1EAI 1EAI 1EAI 1EAI Huang et al., 1994
complex with 3-[[(methylamino)sulfonyl]amino]-2-oxo-6-phenyl-N-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-1(2H)-pyridine acetamide 1.80 Å 1EAS 1EAS 1EAS 1EAS 1EAS 1EAS Bernstein et al., 1994
complex with 2-[5-methanesulfonylamino-2-(4-aminophenyl)--6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl) acetamide 2.00 Å 1EAT 1EAT 1EAT 1EAT 1EAT 1EAT Veale et al., 1995
complex with 2-[5-amino--6-oxo-2-(2-thienyl)-1,6-dihydropyrimidin-1-yl)-N-[3,3-difluoro-1-isopropyl-2-oxo-3-(N-(2-morpholinoethyl)carbamoyl)propyl] acetamide 2.00 Å 1EAU 1EAU 1EAU 1EAU 1EAU 1EAU Bernstein et al., 1995
complex with trifluoroacetyl-L-Lys-L-Pro-isopropylanilide 1.80 Å 1ELA 1ELA 1ELA 1ELA 1ELA 1ELA Mattos et al., 1994
complex with trifluoroacetyl-L-Lys-L-Leu-isopropylanilide 2.10 Å 1ELB 1ELB 1ELB 1ELB 1ELB 1ELB Mattos et al., 1994
complex with trifluoroacetyl-L-Phe-P-isopropylanilide 1.75 Å 1ELC 1ELC 1ELC 1ELC 1ELC 1ELC Mattos et al., 1994
complex with trifluoroacetyl-L-Phe-L-Ala-p-trifluoromethylanilide 1.80 Å 1ELD 1ELD 1ELD 1ELD 1ELD 1ELD Mattos et al., 1995
complex with trifluoroacetyl-L-Val-L-Ala-p-itrifluoromethylanilide 1.80 Å 1ELE 1ELE 1ELE 1ELE 1ELE 1ELE Mattos et al., 1995
complex with N-(tert-butoxycarbonyl-Ala-Ala)-O-(p-nitrobenzoyl) hydroxylamine 1.70 Å 1ELF 1ELF 1ELF 1ELF 1ELF 1ELF Ding et al., 1995
complex with N-(tert-butoxycarbonyl-Ala-Ala)-O-(p-nitrobenzoyl) hydroxylamine at pH5 1.65 Å 1ELG 1ELG 1ELG 1ELG 1ELG 1ELG Ding et al., 1995
low temperature form (-45 C) 1.65 Å 1ESA 1ESA 1ESA 1ESA 1ESA 1ESA Ding et al., 1994
complex with N-carbobenzoxy-L-Ala-p-nitrophenol ester 2.30 Å 1ESB 1ESB 1ESB 1ESB 1ESB 1ESB Ding et al., 1994
TOS-elastase 2.50 Å 1EST 1EST 1EST 1EST 1EST 1EST Sawyer et al., 1978
complex with elafin 1.90 Å 1FLE 1FLE 1FLE 1FLE 1FLE 1FLE Tsunemi et al., 1996
complex with inhibitor ONO-6818 1.86 Å 1FZZ 1FZZ 1FZZ 1FZZ 1FZZ 1FZZ Odagaki et al., 2001
mature  peptidase 0.94 Å 1GVK 1GVK 1GVK 1GVK 1GVK 1GVK Katona et al., 2002
triiodide derivative 1.85 Å 1GWA 1GWA 1GWA 1GWA 1GWA 1GWA Evans & Bricogne, 2002
complex with acetyl-Val-Glu-Pro-Ile-COOH 1.67 Å 1H9L 1H9L 1H9L 1H9L 1H9L 1H9L Wright et al., 2001
acyl-enzyme intermediate; complex with human beta-casomorphin-7 at pH 5 1.60 Å 1HAX 1HAX 1HAX 1HAX 1HAX 1HAX Wilmouth et al., 2001
acyl-enzyme intermediate; complex with human beta-casomorphin-7 jumped to pH 10 for 10 seconds 1.70 Å 1HAY 1HAY 1HAY 1HAY 1HAY 1HAY Wilmouth et al., 2001
acyl-enzyme intermediate; complex with human beta-casomorphin-7 jumped to pH 9 for 1 minute 1.40 Å 1HAZ 1HAZ 1HAZ 1HAZ 1HAZ 1HAZ Wilmouth et al., 2001
acyl-enzyme intermediate; complex with human beta-casomorphin-7 jumped to pH 10 for 2 minutes 2.05 Å 1HB0 1HB0 1HB0 1HB0 1HB0 1HB0 Wilmouth et al., 2001
complex with N-[2-(1-formyl-2-methyl-propyl)-1-(4-piperidin-1-ylbut-2-enoyl)-pyrrolidin-3-yl]-methane sulfonoamide 1.70 Å 1HV7 1HV7 1HV7 1HV7 1HV7 1HV7 Macdonald et al., 2001
complex with benzoxazinone inhibitor 1.94 Å 1INC 1INC 1INC 1INC 1INC 1INC Radhakrishnan et al., 1987
complex with 3-methoxy-4-chloro-7-aminoisocoumarin inhibitor 2.31 Å 1JIM 1JIM 1JIM 1JIM 1JIM 1JIM Meyer et al., 1985
complex with xenon and bromide, cryoprotected with dry paraffin oil 1.50 Å 1L0Z 1L0Z 1L0Z 1L0Z 1L0Z 1L0Z Panjikar & Tucker, 2002
complex with xenon and bromide, cryoprotected with glycerol 1.50 Å 1L1G 1L1G 1L1G 1L1G 1L1G 1L1G Panjikar & Tucker, 2002
with calcium 1.70 Å 1LKA 1LKA 1LKA 1LKA 1LKA 1LKA Weiss et al., 2002
without calcium 1.70 Å 1LKB 1LKB 1LKB 1LKB 1LKB 1LKB Weiss et al., 2002
mature  peptidase 1.65 Å 1LVY 1LVY 1LVY 1LVY 1LVY 1LVY Schiltz et al., 1997
complex with hybrid squash inhibitor HEI-TOE 1 1.80 Å 1MCV 1MCV 1MCV 1MCV 1MCV 1MCV Ay et al., 2003
complex with inhibitor FR136706 2.20 Å 1MMJ 1MMJ 1MMJ 1MMJ 1MMJ 1MMJ Kinoshita et al., 2003
complex with acetyl-Ala-Pro-Ala 1.65 Å 1NES 1NES 1NES 1NES 1NES 1NES Meyer et al., 1986
binding structure of elastase inhibitor scyptolin a 2.80 Å 1OKX 1OKX 1OKX 1OKX 1OKX 1OKX Matern et al., 2003
complex with (3R,4S)N-para-toluenesulfonyl-3-ethyl-4-(carboxylic acid)pyrrolidin-2-one 1.70 Å 1QGF 1QGF 1QGF 1QGF 1QGF 1QGF Wilmouth et al., 1999
complex with human beta- casomorphin-7 1.90 Å 1QIX 1QIX 1QIX 1QIX 1QIX 1QIX Wilmouth et al., 1997
mature  peptidase 1.10 Å 1QNJ 1QNJ 1QNJ 1QNJ 1QNJ 1QNJ Wurtele et al., 2000
complex with macrocyclic inhibitor FR901277 1.60 Å 1QR3 1QR3 1QR3 1QR3 1QR3 1QR3 Nakanishi et al., 2000
porcine pancreatic elastase/xe-complex 1.65 Å 1UO6 1UO6 1UO6 1UO6 1UO6 1UO6 Mueller-Dieckmann et al., 2004
complex with cadmium (crystal A) 1.85 Å 1UVO 1UVO 1UVO 1UVO 1UVO 1UVO Weiss et al., 2005
complex with cadmium (crystal B) 1.85 Å 1UVP 1UVP 1UVP 1UVP 1UVP 1UVP Weiss et al., 2005
mature  peptidase 1.65 Å 2A7C 2A7C 2A7C 2A7C 2A7C 2A7C Mueller-Dieckmann et al., 2005
mature  peptidase 1.65 Å 2A7J 2A7J 2A7J 2A7J 2A7J 2A7J Mueller-Dieckmann et al., 2005
complex with beta-casomorphin- 7 and Asp-Phe at pH 5.0 1.60 Å 2BB4 2BB4 2BB4 2BB4 2BB4 2BB4 Liu et al., 2006
complex with beta-casomorphin- 7 and Arg-Phe at pH 5.0 1.70 Å 2BD2 2BD2 2BD2 2BD2 2BD2 2BD2 Liu et al., 2006
complex with beta-casomorphin- 7 and Lys-Ala-NH2 at pH 5.0 1.60 Å 2BD3 2BD3 2BD3 2BD3 2BD3 2BD3 Liu et al., 2006
complex with beta-casomorphin- 7 and Lys-Ser at pH 5.0 1.70 Å 2BD4 2BD4 2BD4 2BD4 2BD4 2BD4 Liu et al., 2006
complex with beta-casomorphin- 7 and Lys-Ser at ph 5 and immersed in pH 9 buffer for 30 seconds 1.80 Å 2BD5 2BD5 2BD5 2BD5 2BD5 2BD5 Liu et al., 2006
complex with beta-casomorphin- 7 and Arg-Phe at pH 5.0 (50 min soak) 1.60 Å 2BD7 2BD7 2BD7 2BD7 2BD7 2BD7 Liu et al., 2006
complex with beta-casomorphin- 7 and Arg-Phe at pH 5.0 (50 min soak) and immersed in ph 9 buffer for 30 seconds 1.70 Å 2BD8 2BD8 2BD8 2BD8 2BD8 2BD8 Liu et al., 2006
complex with beta-casomorphin- 7 and Arg-Phe at pH 5.0 (50 min soak) and immersed in ph 9 buffer for 28 seconds (2nd ph jump) 1.90 Å 2BD9 2BD9 2BD9 2BD9 2BD9 2BD9 Liu et al., 2006
complex with N-acetyl-Asn-Pro-Ile and Ala-Ala at pH 5.0 1.80 Å 2BDA 2BDA 2BDA 2BDA 2BDA 2BDA Liu et al., 2006
complex with Asn-Pro-Ile and Ala-Ala at pH 5.0 1.70 Å 2BDB 2BDB 2BDB 2BDB 2BDB 2BDB Liu et al., 2006
complex with Asn-Pro-Ile at pH 5.0 1.80 Å 2BDC 2BDC 2BDC 2BDC 2BDC 2BDC Liu et al., 2006
elastase before a high dose x-ray "burn" 1.33 Å 2BLO 2BLO 2BLO 2BLO 2BLO 2BLO Nanao et al., 2005
elastase after a high dose x-ray "burn" 1.33 Å 2BLQ 2BLQ 2BLQ 2BLQ 2BLQ 2BLQ Nanao et al., 2005
complex with FR901451 1.90 Å 2CV3 2CV3 2CV3 2CV3 2CV3 2CV3 Kinoshita et al., 2005
complex with alpha-1-proteinase inhibitor 3.30 Å 2D26 2D26 2D26 2D26 2D26 2D26 Dementiev et al., 2006
unique conformation induced by tris 1.50 Å 2DE8 2DE8 2DE8 2DE8 2DE8 2DE8 Kinoshita et al., 2006
complex with tris after soaking in a tris-free solution 1.30 Å 2DE9 2DE9 2DE9 2DE9 2DE9 2DE9 Kinoshita et al., 2006
complex with trifluoroacetyl-L-Lys-L-Ala-p-trifluoromethylphenylanilide 2.50 Å 2EST 2EST 2EST 2EST 2EST 2EST Hughes et al., 1982
in 95% acetone 2.00 Å 2FO9 2FO9 2FO9 2FO9 2FO9 2FO9 Mattos et al., 2006
in 40/50/10 % benzene 1.90 Å 2FOA 2FOA 2FOA 2FOA 2FOA 2FOA Mattos et al., 2006
in 40/50/10 cyclohexane 1.90 Å 2FOB 2FOB 2FOB 2FOB 2FOB 2FOB Mattos et al., 2006
in 55% dimethylformamide 2.00 Å 2FOC 2FOC 2FOC 2FOC 2FOC 2FOC Mattos et al., 2006
in 80% ethanol 2.00 Å 2FOD 2FOD 2FOD 2FOD 2FOD 2FOD Mattos et al., 2006
in 80% hexane 2.20 Å 2FOE 2FOE 2FOE 2FOE 2FOE 2FOE Mattos et al., 2006
in 80% isopropanol 2.20 Å 2FOF 2FOF 2FOF 2FOF 2FOF 2FOF Mattos et al., 2006
in 40% trifluoroethanol 1.90 Å 2FOG 2FOG 2FOG 2FOG 2FOG 2FOG Mattos et al., 2006
in 40% trifluoroethanol 1.80 Å 2FOH 2FOH 2FOH 2FOH 2FOH 2FOH Mattos et al., 2006
anomalous substructure 2.15 Å 2G4T 2G4T 2G4T 2G4T 2G4T 2G4T Mueller-Dieckmann et al., 2007
anomalous substructure 1.84 Å 2G4U 2G4U 2G4U 2G4U 2G4U 2G4U Mueller-Dieckmann et al., 2007
complex with Met-Phe-Leu-Glu at pH 5.0 1.60 Å 2H1U 2H1U 2H1U 2H1U 2H1U 2H1U Liu et al., 2006
clavulanic acid bound to elastase 1.60 Å 2IOT 2IOT 2IOT 2IOT 2IOT 2IOT
high pressure cryocooling of capillary sample cryoprotection and diffraction phasing at long wavelengths 1.80 Å 2OQU 2OQU 2OQU 2OQU 2OQU 2OQU Kim et al., 2007
sad structure solution porcine pancreatic elastase from a selenate derivative 1.65 Å 2V0B 2V0B 2V0B 2V0B 2V0B 2V0B
complex with inhibitor JM54 1.67 Å 2V35 2V35 2V35 2V35 2V35 2V35 Oliveira et al., 2007
with the magic triangle i3c 1.60 Å 3E3T 3E3T 3E3T 3E3T 3E3T 3E3T
mature  peptidase 1.65 Å 3EST 3EST 3EST 3EST 3EST 3EST Meyer et al., 1988
mature  peptidase 1.65 Å 3HGN 3HGN 3HGN 3HGN 3HGN 3HGN Tamada et al., 2009
mature  peptidase 0.94 Å 3HGP 3HGP 3HGP 3HGP 3HGP 3HGP Tamada et al., 2009
mature  peptidase 1.20 Å 3MNB 3MNB 3MNB 3MNB 3MNB 3MNB Petrova et al., 2010
mature  peptidase 1.12 Å 3MNC 3MNC 3MNC 3MNC 3MNC 3MNC Petrova et al., 2010
mature  peptidase 1.50 Å 3MNS 3MNS 3MNS 3MNS 3MNS 3MNS Petrova et al., 2010
mature  peptidase 1.39 Å 3MNX 3MNX 3MNX 3MNX 3MNX 3MNX Petrova et al., 2010
mature  peptidase 1.80 Å 3MO3 3MO3 3MO3 3MO3 3MO3 3MO3 Petrova et al., 2010
mature  peptidase 1.66 Å 3MO6 3MO6 3MO6 3MO6 3MO6 3MO6 Petrova et al., 2010
mature  peptidase 2.00 Å 3MO9 3MO9 3MO9 3MO9 3MO9 3MO9 Petrova et al., 2010
mature  peptidase 1.82 Å 3MOC 3MOC 3MOC 3MOC 3MOC 3MOC Petrova et al., 2010
mature  peptidase 1.10 Å 3MTY 3MTY 3MTY 3MTY 3MTY 3MTY Petrova et al., 2010
mature  peptidase 1.40 Å 3MU0 3MU0 3MU0 3MU0 3MU0 3MU0 Petrova et al., 2010
mature  peptidase 1.74 Å 3MU1 3MU1 3MU1 3MU1 3MU1 3MU1 Petrova et al., 2010
mature  peptidase 1.10 Å 3MU4 3MU4 3MU4 3MU4 3MU4 3MU4 Petrova et al., 2010
mature  peptidase 1.40 Å 3MU5 3MU5 3MU5 3MU5 3MU5 3MU5 Petrova et al., 2010
mature  peptidase 1.55 Å 3MU8 3MU8 3MU8 3MU8 3MU8 3MU8 Petrova et al., 2010
mature  peptidase 1.10 Å 3ODD 3ODD 3ODD 3ODD 3ODD 3ODD Petrova et al., 2010
mature  peptidase 1.10 Å 3ODF 3ODF 3ODF 3ODF 3ODF 3ODF Petrova et al., 2010
mature  peptidase 2.00 Å 3UOU 3UOU 3UOU 3UOU 3UOU 3UOU Garcia-Fernandez et al., 2015
complex with ACE-Ala-Pro-Val-difluoro-N-phenylethylacetamide 1.78 Å 4EST 4EST 4EST 4EST 4EST 4EST
mature  peptidase 1.55 Å 4GVU 4GVU 4GVU 4GVU 4GVU 4GVU Salvador et al., 2013
complex withthe novel inhibitor jm102 1.80 Å 4YM9 4YM9 4YM9 4YM9 4YM9 4YM9
mature  peptidase 0.86 Å 5AVD 5AVD 5AVD 5AVD 5AVD 5AVD Sugiyama et al., 2012
complex with carbobenzoxy-Ala-Ile boronic acid 2.09 Å 5EST 5EST 5EST 5EST 5EST 5EST Takahashi et al., 1989
crystallized in 10% DMF 1.80 Å 6EST 6EST 6EST 6EST 6EST 6EST de et al., 1990
complex with trifluoroacetyl-L-Leu-L-Ala-p-trifluoromethylphenylanilide 1.80 Å 7EST 7EST 7EST 7EST 7EST 7EST de et al., 1990
complex with guanidinium isocoumarin 1.78 Å 8EST 8EST 8EST 8EST 8EST 8EST Powers et al., 1990
complex with guanidinium isocoumarin 1.90 Å 9EST 9EST 9EST 9EST 9EST 9EST Vijayalakshmi et al., 1991

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