Structure analysis

Complex I from Ovis aries at pH9, Closed state

Electron Microscopy
3.8Å resolution
Source organism: Ovis aries
Assembly composition:
hetero 45-mer (preferred)
Entry contents: 44 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 45-mer
Accessible surface area: 271352.24 Å2
Buried surface area: 286922.53 Å2
Dissociation area: 1,232.56 Å2
Dissociation energy (ΔGdiss): 2.21 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-105808

Macromolecules

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Chain: A
Length: 115 amino acids
Theoretical weight: 13.11 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: O78753 (Residues: 1-115; Coverage: 100%)
Gene names: MT-ND3, MTND3, NADH3, ND3
Pfam: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
InterPro:

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Chain: H
Length: 318 amino acids
Theoretical weight: 35.88 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: O78747 (Residues: 1-318; Coverage: 100%)
Gene names: MT-ND1, MTND1, NADH1, ND1
Pfam: NADH dehydrogenase
InterPro:

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Chain: J
Length: 175 amino acids
Theoretical weight: 19.13 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: O78757 (Residues: 1-175; Coverage: 100%)
Gene names: MT-ND6, MTND6, NADH6, ND6
Pfam: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
InterPro:

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Chain: K
Length: 98 amino acids
Theoretical weight: 10.87 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: O78754 (Residues: 1-98; Coverage: 100%)
Gene names: MT-ND4L, MTND4L, NADH4L, ND4L
Pfam: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
InterPro:

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Chain: N
Length: 347 amino acids
Theoretical weight: 39.15 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: O78748 (Residues: 1-347; Coverage: 100%)
Gene names: MT-ND2, MTND2, NADH2, ND2
Pfam:
InterPro:

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Chain: V
Length: 140 amino acids
Theoretical weight: 14.65 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A8N7XJ91 (Residues: 2-141; Coverage: 99%)
Gene name: JEQ12_016431
Pfam: Tim17/Tim22/Tim23/Pmp24 family
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

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Chain: W
Length: 139 amino acids
Theoretical weight: 16.32 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A8N7XJ68 (Residues: 51-189; Coverage: 74%)
Gene name: JEQ12_001574
Pfam: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
InterPro: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

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Chains: X, j
Length: 157 amino acids
Theoretical weight: 17.61 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5NQT7 (Residues: 1-157; Coverage: 100%)
Pfam: Phosphopantetheine attachment site
InterPro:

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Chain: Y
Length: 171 amino acids
Theoretical weight: 20.01 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A8N7XJG2 (Residues: 2-172; Coverage: 99%)
Gene name: JEQ12_013613
Pfam: CHCH domain
InterPro:

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Chain: Z
Length: 171 amino acids
Theoretical weight: 20.53 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P3EI17 (Residues: 4-174; Coverage: 97%)
Gene name: JEQ12_012218
Pfam: NADH-ubiquinone oxidoreductase subunit 10
InterPro:

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Chain: k
Length: 320 amino acids
Theoretical weight: 36.88 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A8N7XJK5 (Residues: 36-355; Coverage: 90%)
Gene name: JEQ12_000054
Pfam: Deoxynucleoside kinase
InterPro:

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Chain: l
Length: 105 amino acids
Theoretical weight: 12.47 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A836D7R1 (Residues: 192-296; Coverage: 36%)
Gene name: JEQ12_000171
Pfam: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
InterPro: NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5

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Chain: m
Length: 80 amino acids
Theoretical weight: 8.87 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A836A4Q3 (Residues: 42-121; Coverage: 66%)
Gene name: JEQ12_005750
Pfam: NADH dehydrogenase 1 alpha subcomplex subunit 3
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

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Chain: n
Length: 79 amino acids
Theoretical weight: 8.96 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P7DQB1 (Residues: 12-90; Coverage: 81%)
Gene name: JEQ12_009750
Pfam: NADH-ubiquinone oxidoreductase B12 subunit family
InterPro: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

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Chain: o
Length: 120 amino acids
Theoretical weight: 14.23 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5P9Q8 (Residues: 3-122; Coverage: 98%)
Gene name: NDUFC2
Pfam: NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
InterPro: NADH dehydrogenase [ubiquinone] 1 subunit C2, NDUC2

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Chain: p
Length: 128 amino acids
Theoretical weight: 14.98 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5QF73 (Residues: 3-130; Coverage: 99%)
Gene name: NDUFB4
Pfam: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
InterPro: NADH:ubiquinone oxidoreductase, subunit NDUFB4

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Chain: q
Length: 139 amino acids
Theoretical weight: 16.28 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P3E975 (Residues: 6-144; Coverage: 97%)
Pfam: GRIM-19 protein
InterPro: GRIM-19

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Chain: r
Length: 126 amino acids
Theoretical weight: 15.3 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5PZE3 (Residues: 2-127; Coverage: 98%)
Gene name: NDUFB6
Pfam: NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit
InterPro: NADH dehydrogenase 1, beta subcomplex, subunit 6

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Chain: s
Length: 122 amino acids
Theoretical weight: 14.96 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A8N7XJH2 (Residues: 2-123; Coverage: 89%)
Gene name: JEQ12_016212
Pfam: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
InterPro: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, NDUB7

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Chain: t
Length: 177 amino acids
Theoretical weight: 21.52 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P3E749 (Residues: 2-178; Coverage: 99%)
Gene name: JEQ12_019240
Pfam: Complex 1 protein (LYR family)
InterPro:

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Chain: u
Length: 65 amino acids
Theoretical weight: 7.9 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A8N7XJB4 (Residues: 41-105; Coverage: 60%)
Gene name: JEQ12_015775
Pfam: NADH dehydrogenase 1 beta subcomplex subunit 2
InterPro: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, animal type

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Chain: v
Length: 155 amino acids
Theoretical weight: 18.52 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5Q1B0 (Residues: 32-186; Coverage: 83%)
Gene name: NDUFB8
Pfam: NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
InterPro:

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Chain: w
Length: 101 amino acids
Theoretical weight: 12 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A836CQA7 (Residues: 48-148; Coverage: 67%)
Gene name: JEQ12_020035
Pfam: ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
InterPro: NADH:ubiquinone oxidoreductase, ESSS subunit

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Chain: x
Length: 49 amino acids
Theoretical weight: 5.81 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P3EDV0 (Residues: 28-76; Coverage: 65%)
Pfam: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
InterPro: NADH-ubiquinone oxidoreductase 1 subunit C1

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Chain: y
Length: 50 amino acids
Theoretical weight: 6.15 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A7M4DUG1 (Residues: 9-58; Coverage: 86%)
Pfam: MNLL subunit
InterPro: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NDUB1

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Chain: z
Length: 70 amino acids
Theoretical weight: 8.21 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P9FRJ5 (Residues: 1-70; Coverage: 100%)
Pfam: NADH-ubiquinone oxidoreductase MWFE subunit
InterPro: NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1

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Chain: 2
Length: 213 amino acids
Theoretical weight: 23.6 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5NRY1 (Residues: 34-246; Coverage: 87%)
Gene name: NDUFV2
Pfam: Thioredoxin-like [2Fe-2S] ferredoxin
InterPro:

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Chain: 6
Length: 150 amino acids
Theoretical weight: 17.17 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P7E5N1 (Residues: 74-223; Coverage: 67%)
Pfam: NADH ubiquinone oxidoreductase, 20 Kd subunit
InterPro:

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Chain: 9
Length: 217 amino acids
Theoretical weight: 24.5 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P3TFB2 (Residues: 1-217; Coverage: 100%)
Pfam: 4Fe-4S dicluster domain
InterPro:

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Chain: a
Length: 44 amino acids
Theoretical weight: 5.26 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P3E7B5 (Residues: 66-109; Coverage: 40%)
Pfam: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
InterPro: NADH-ubiquinone oxidoreductase flavoprotein 3

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Chain: b
Length: 95 amino acids
Theoretical weight: 10.51 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P7EX23 (Residues: 29-123; Coverage: 77%)
Gene name: JEQ12_007015
Pfam: Zinc-finger domain
InterPro:

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Chain: c
Length: 126 amino acids
Theoretical weight: 14.56 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5PE07 (Residues: 45-170; Coverage: 74%)
Gene name: NDUFS4
Pfam: NADH dehydrogenase ubiquinone Fe-S protein 4
InterPro:

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Chain: d
Length: 340 amino acids
Theoretical weight: 38.86 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A6P3E3I5 (Residues: 36-375; Coverage: 90%)
Gene name: JEQ12_015054
Pfam: NAD dependent epimerase/dehydratase family
InterPro:

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Chain: f
Length: 113 amino acids
Theoretical weight: 13.03 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5NRE6 (Residues: 4-116; Coverage: 97%)
Pfam: ETC complex I subunit conserved region
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

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Chain: g
Length: 114 amino acids
Theoretical weight: 13.77 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5QC06 (Residues: 27-140; Coverage: 81%)
Gene name: NDUFA6
Pfam: Complex 1 protein (LYR family)
InterPro:

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Chain: h
Length: 112 amino acids
Theoretical weight: 12.44 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: W5P0I2 (Residues: 3-114; Coverage: 98%)
Gene name: NDUFA7
Pfam: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

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Chain: i
Length: 145 amino acids
Theoretical weight: 17.12 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: A0A8N7XJ18 (Residues: 1-145; Coverage: 100%)
Gene name: JEQ12_014294
Pfam: NADH ubiquinone oxidoreductase subunit NDUFA12
InterPro: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

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